The Effect of Pseudoexfoliation and Pseudoexfoliation Induced Dry Eye on Central Corneal Thickness

Akdemir, Mehmet; Kirgiz, Ahmet; Ayar, Orhan; Kaldırım, Havva; Mert, Metin; Çabuk, Kübra Şerefoğlu; Taşkapili, Mühittin

doi:10.3109/02713683.2015.1030505

Cited by 13 publications

(16 citation statements)

References 32 publications

(40 reference statements)

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“…Our results from dry eye tests indicated that dry eye symptoms and clinical signs were developed in patients seven days after cataract surgery, especially in PEX patients without postoperatively prescribed AT. This fact is similar to some earlier studies [3,21,22]. One month after phacoemulsification, patients without PEX showed better results in all tests except in TBUT.…”

Section: Discussionsupporting

confidence: 92%

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The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

et al. 2018

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Introduction/Objective Dry eye development after phacoemulsification is a very common complication of cataract surgery. Combined with other risk factors, such as pseudoexfoliation (PEX), this complication becomes more frequent. The aim of this study was to expose the influence of phacoemulsification associated with PEX on the development of dry eye in patients who underwent cataract surgery. Methods The study included 160 eyes (160 patients) who underwent phacoemulsification. The patients were divided into four groups (n = 40 patients). Groups I and II involved patients without PEX. The patients from Group II were prescribed artificial tears (AT) postoperatively. The patients from Groups III and IV had a presentation of PEX. The patients from Group IV got AT postoperatively. Ocular Surface Disease Index, the tear breakup time (TBUT) test, fluorescein staining, and Schirmer's test served as "dry eye" tests in this study. The χ 2 test and paired t-test were used for data analysis. Results Measurements were taken for every patient preoperatively, on the first and the seventh day after the surgery, one month and three months, and one year after the surgery. The tests showed postoperatively developed dry eye in all the groups, with the recovery of the tear film within three months, except for Group III. The highest statistical significance (p < 0.001) was recorded between Groups II and III, three and 12 months after the surgery. Values of TBUT (6.09 ± 1.29 seconds) and Schirmer's test (8.91 ± 2.14 mm) in Group III strongly indicated that dry eye was still present one year after phacoemulsification. The greatest recovery of the tear film was recorded in Group II in all the measurements. Conclusion The study showed how strongly PEX and the use of AT affect the tear film during the first postoperative year. Based on our experience, we highly recommend the use of AT after performing phacoemulsification.

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Section: Discussionsupporting

confidence: 92%

“…The accumulation of PEX material in conjunctival tissue influences the accessory lacrimal glands' and goblet cells' function [5]. Some earlier studies indicated instability of the tear film in patients with PEX [21].…”

Section: Discussionmentioning

confidence: 99%

The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

et al. 2018

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“…Tear film secretion was found to be reduced in PES eyes. 25 Disturbances of the precorneal tear film, including a reduced Schirmer test score and tear film break-up time score, have also been found in eyes with PEX material. It is possible that tear film abnormality associated with PES leads to impaired transparency in the anterior corneal layer.…”

Section: Discussionmentioning

confidence: 96%

Effect of Pseudoexfoliation on Corneal Transparency

Cankaya

Tekin²,

İnanç³

2016

Cornea

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“…Результаты исследований про-демонстрировали, что для больных ПЭС/ПЭГ также характерно уменьшение ЦТР. Предпола-гают, что такая особенность роговицы при на-личии указанной патологии может быть связана с уменьшением плотности клеток стромы и поте-рей клеток эндотелия [9,25]. В проведённом нами исследовании, несмотря на то, что у пациентов с ПЭГ ЦТР была ниже, чем в группе контроля (537,8 ± 7,3 и 560,3 ± 5,9 мкм), различия были недостоверны (p = 0,09).…”

Section: Discussionunclassified

Pseudoexfoliative glaucoma and molecular genetic characteristics of vitamin D metabolism

Beletskaya

Станиславовна²,

Astakhov

et al. 2018

Ophthalmology Reports

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Purpose. To study the possible association of 25-hydroxyvitamin D level, and vitamin D receptor (VDR) gene polymorphisms (BsmI, ApaI, TaqI, FokI) with pseudoexfoliative glaucoma (PEG) clinical manifestations. Methods. We examined 160 subjects (72 males (45%), and 88 females (55%)) aged from 55 to 75 years, residents of St. Petersburg and Leningrad region. 122 patients with PEG were enrolled in the main study group, the control group comprised 38 subjects without PEG, primary open angle glaucoma (POUG) and pseudoexfoliation syndrome (PES). 25(OH)D serum levels were assessed by chemiluminescent immunoassay (CLIA) method. Detection of VDR gene allele polymorphisms (ApaI, BsmI, FokI, and TaqI) was carried out using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique. Results. Patients with PEG had lower 25(OH)D serum levels compared to patients in the control group (39.3 ± 1.2 and 52.7 ± 2.1 nMol/l, respectively, p < 0.01). The prevalence of vitamin D deficiency was found to be higher among PEG patients than among healthy subjects (86.4% and 59.5%, respectively, p < 0.01). The prevalence of b allele (p < 0.001) and bb genotype (p < 0.001) (BsmI polymorphism), as well as of f allele and ff genotype (p < 0.05) (FokI polymorphism) in PEG patients were higher compared to healthy subjects. We found that the Fallele carriers (FokI polymorphism) had greater corneal thickness than the ff genotype carriers (547.3 ± 4.1 μm and 502.1 ± 25.8 μm, respectively, p < 0.01). It was revealed, that bb genotype, Bb genotype (BsmI polymorphism), and ff genotype (FokI polymorphism) were associated with the increased risk of PEG (OR = 8.2, CI 95%: 3.4-19.9; OR = 3.9, CI 95%: 1.7-9.0; OR = 2.3, CI 95%: 1.2-4.5, respectively). Conclusions. Results of this study for the first time ever showed the association between BsmI and FokI VDR gene polymorphisms and pseudoexfoliative glaucoma.

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The Effect of Pseudoexfoliation and Pseudoexfoliation Induced Dry Eye on Central Corneal Thickness

Cited by 13 publications

References 32 publications

The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

Effect of Pseudoexfoliation on Corneal Transparency

Pseudoexfoliative glaucoma and molecular genetic characteristics of vitamin D metabolism

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