The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

Todorović, Dušan; Sarenac-Vulovic, Tatjana; Jovanović, Svetlana; Janicijevic-Petrovic, Mirjana; Petrović, Nenad; Kontic, Marko; Miloš, Todorović; Janićijević, Katarina; Srećković, Sunčica

doi:10.2298/sarh170718174t

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Pseudoexfoliative material can disturb the function of goblet cells in conjunctiva, which causes tear film instability and dry eye syndrome. Structure of this material is fibrillar and it contains parts of basal membranes and some enzymes [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients

et al. 2022

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Introduction/Objective. Pseudoexfoliation syndrome is characterized by abnormal production and accumulation of fibrillar, white-gray, ?dandruff-like? material in almost all ocular structures. The aim of this study was to examine effect of selective laser trabeculoplast in pseudoexfoliation glaucoma patients. Methods. Thirty-two patients (47 eyes) were enrolled with medically uncontrolled pseudoexfoliation glaucoma. All patients could not reach target intraocular pressure with maximal tolerated medical therapy before treatment. Selective laser trabeculoplasty was performed with about 100 non-overlapping spots. Intraocular pressure was measured 1 hour, 7 days, 4 weeks, 3, 6, 12, 18 and 24 months after procedure. Results. The mean base intraocular pressure was 23.45 mmHg (SD = 3.07). Statistically significant reduction of mean intraocular pressure was observed at all follow-ups except 1 hour after treatment. Mean intraocular pressure after 24 months was 18.39mmHg (SD = 1.82). Success, defined as intraocular pressure reduction from base IOP of more than 20% after 24 months, was achieved in 27 eyes (57.45%). We did not find any influence of sex and age on selective laser trabeculoplasty effects in pseudoexfoliative glaucoma patients. Baseline intraocular pressure is proved to be reliable predictor of intraocular pressure lowering effect, as there were strong correlation between baseline intraocular pressure and percentage of reduction of intraocular pressure after 24 months (r = 0.71, p < 0.01). Conclusion. Selective laser trabeculoplasty is safe and effective method for reduction of intraocular pressure in pseudoexfoliation glaucoma patients and should be used more often in this challenging form of glaucoma. Baseline intraocular pressure seems to be reliable predictor of success.

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Section: Introductionmentioning

confidence: 99%

Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients

et al. 2022

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Quality of life of patients with primary open-angle glaucoma, primary angle closure glaucoma, and pseudoexfoliation glaucoma in Central Serbia

Marceta,

Sarenac-Vulovic,

Petrovic

et al. 2023

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Background/Aim. Impaired vision resulting from glaucoma can have deleterious effects on both physical and mental health. This study aims at examining the adverse impacts of primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG) and pseudoexfoliation glaucoma (PEG) on the quality of life (QOL). Methods. This research, designed as a cross-sectional study, included 102 patients treated for POAG, PACG, or PEG. The patients were divided into three groups based on the type of glaucoma they suffered from and were monitored for 6 months. The data on the QOL were collected with National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25). The total NEI VFQ-25 scores were calculated for each group. Results. The general vision was significantly lower in the PEG group than in the remaining groups (PEG 61.1 ? 12.6, POAG 71.6 ? 17.9, PACG 75.7 ? 11.6), p < 0.001. This group also demonstrated the least favorable levels of general health, eye pain, distance vision, social functioning, peripheral vision, disability in daily activities, and dependence of others. The highest value of near vision was recorded for the POAG group (76.2 ? 21.2). The highest mean value in glaucomatous visual field defect was recorded in PEG group (14.5 ? 3.6 dB). Conclusion. This research demonstrates that the quality of life is significantly lower in patients suffering from PEG compared to those who suffer from POAG and PACG. In PEG patients, the lowest scores were recorded for general health, eye pain, distance vision, and social and everyday functioning. The results indicate that serious measures should be taken in order to improve the quality of life of glaucoma patients.

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Machine Learning Analytics of Resting-State Functional Connectivity Predicts Survival Outcomes of Glioblastoma Multiforme Patients

et al. 2021

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Glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy. Due to its poor prognosis with currently available treatments, there is a pressing need for easily accessible, non-invasive techniques to help inform pre-treatment planning, patient counseling, and improve outcomes. In this study we determined the feasibility of resting-state functional connectivity (rsFC) to classify GBM patients into short-term and long-term survival groups with respect to reported median survival (14.6 months). We used a support vector machine with rsFC between regions of interest as predictive features. We employed a novel hybrid feature selection method whereby features were first filtered using correlations between rsFC and OS, and then using the established method of recursive feature elimination (RFE) to select the optimal feature subset. Leave-one-subject-out cross-validation evaluated the performance of models. Classification between short- and long-term survival accuracy was 71.9%. Sensitivity and specificity were 77.1 and 65.5%, respectively. The area under the receiver operating characteristic curve was 0.752 (95% CI, 0.62–0.88). These findings suggest that highly specific features of rsFC may predict GBM survival. Taken together, the findings of this study support that resting-state fMRI and machine learning analytics could enable a radiomic biomarker for GBM, augmenting care and planning for individual patients.

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The impact of pseudoexfoliation and arteficial tear application on tear film stability in a pseudophakic eye

Cited by 3 publications

References 22 publications

Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients

Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients

Quality of life of patients with primary open-angle glaucoma, primary angle closure glaucoma, and pseudoexfoliation glaucoma in Central Serbia

Machine Learning Analytics of Resting-State Functional Connectivity Predicts Survival Outcomes of Glioblastoma Multiforme Patients

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