The Effect of Protease Inhibitor on Reperfusion Injury After Unilateral Pulmonary Ischemia

Horiguchi, Tomohiro; Harada, Yukio

doi:10.1097/00007890-199302000-00004

Cited by 18 publications

(8 citation statements)

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“…Lung transplantation is more technically advanced and might encounter many confounding factors such as organ preservation condition, infection, and rejection. The pulmonary hilum occlusion model, used to simulate organ transplantation and applied in the present study, can be classified as mass clamp [22,23] that controls the hilar vessels individually [20,21]. We regarded the latter as a more accurate method of controlling the vessels and airway.…”

Section: Discussionmentioning

confidence: 99%

Effects of Gabexate Mesilate (FOY) on Ischemia–Reperfusion-Induced Acute Lung Injury in Dogs

Luh

Tsai

Shau

et al. 1999

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Effects of Gabexate Mesilate (FOY) on Ischemia–Reperfusion-Induced Acute Lung Injury in Dogs

Luh

Tsai

Shau

et al. 1999

Journal of Surgical Research

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“…Thus, reperfusion damage may extend to organs located at a distance, due to a systemic inflammatory response in which inflammatory mediators are produced and released into circulation 4,7 .…”

Section: Introductionmentioning

confidence: 99%

The role of N-acetyl-cysteine in the lung remote injury after hepatic ischemia and reperfusion in rabbits

Castro

Lauz

et al. 2012

Acta Cir. Bras.

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PURPOSE:To study the lesions in the lung of rabbits caused by ischemia/reperfusion hepatic (I/R) after the use of N-acetyl-cysteine (NAC). METHODS: Twenty-four rabbits distributed in two groups: control group GI (n = 12) 5% glucose solution and experiment group GII (n = 12) NAC. The animals were pre-anesthetized with 1% acepromazine maleate and anesthetized with ketamine 10% and 2% xylazine intramuscularly. The GI and GII were given glucose solution intravenously or NAC 15min before occlusion of the hepatic pedicle (30 min). After the period of reperfusion of 24h (n = 6) or 48h (n = 6), liver and lung samples were collected for histology and immunohistochemistry to assess the impairment of cell. RESULTS:The animals of GII and GII-24h-48h showed parenchyma liver close to normal, when using NAC. The GII and GII-24h-48h showed lower thickness of alveolar cells that GI and GI-24h-48h. The expression of caspase 3 in lung cells GII presented smaller value compared to the GI group. CONCLUSION: N-acetyl-cysteine administered 15min prior to the injury ischemia/reperfusion had a significant protective role by minimizing lung injury and apoptotic morphology in the period observed. Key words: Acetylcysteine. Lung. Reperfusion. Ischemia. Liver. Rabbits. RESUMO OBJETIVO:Estudar as lesões no fígado e no pulmão de coelhos, provocadas pela isquemia/reperfusão hepática (I/R) moduladas pelo uso da N-acetil-cisteína (NAC). MÉTODOS: Vinte e quatro coelhos distribuídos em dois grupos: Grupo controle GI (n=12) solução de glicose 5% e Grupo experimento GII (n=12) NAC. Os animais foram pré-anestesiados com maleato de acepromazina 1% e anestesiados com cloridrato de quetamina 10% e xilazina 2% via intramuscular. Os grupos GI e GII receberam solução glicosada ou NAC respectivamente via endovenosa 15min antes da oclusão do pedículo hepático (30 min). Após iniciou-se o período de reperfusão por 24h (n=6) ou 48h (n=6), terminada a reperfusão, amostras do fígado e pulmão foram coletadas para a histologia e imunoistoquímica para avaliar o comprometimento celular. RESULTADOS: Os animais do grupo GII-24h e GII-48h apresentaram arquitetura do parênquima hepático próximo do normal, quando se utilizou NAC. Os grupos GII-24h e GII-48h apresentaram menor espessura das células alveolares que os grupos GI-24h e GI-48h. A expressão da caspase 3 nas células pulmonares do grupo GII, apresentou valor menor comparada ao grupo GI. CONCLUSÃO: A N-acetil-cisteína administrada 15min prévios a lesão da isquemia/reperfusão teve um papel protetor significativo minimizando as lesões morfológicas e apoptóticas pulmonares nos períodos observados. Descritores: Acetilcisteína. Pulmão. Reperfusão. Isquemia. Fígado. Coelhos.

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“…Reperfusion can damage individually an organ severed by ischemia, as it occurs in organ transplantations or it can extent to other organs, due to a systemic inflammatory response, in which inflammatory mediators are produced and released in the blood flow, reaching deferent organs [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

Delbin

Antunes

Zanesco

2009

Rev Bras Cir Cardiovasc

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Advances in new technologies associated with improvement of knowledge in medicine have promoted important development in therapeutic and preventive approaches in an attempt to diminish complications following cardiothoracic process involving ischemia/ reperfusion (IR). Nevertheless, postoperative pulmonary injuries remain high and are considered one of the most frequent complications after cardiothoracic surgery. Thus, new strategies with prophylactic actions are crucial in the cardiovascular area in an attempt to reduce complications and to improve patients life. It is well documented that moderate exercise training is a non-pharmacological tool to prevent and/or treat the cardiovascular and endocrinemetabolic diseases. The aim of this review was to provide an update of several studies on pulmonary IR process and its local and systemic complications and the role of inflammatory response. Furthermore, this review focused on the effects of exercise training on the pulmonary IR as an important strategy to diminish its complications. This review shows that few studies exist regarding the healthpromoting physical exercise in cardiothoracic surgery and how important and necessary it is to increase studies in this area. Recently, studies from our laboratory showed beneficial effects of exercise training in experimental model of pulmonary IR. Collectively, data show that physical preconditioning for patients is a very important approach to reduce postsurgical complications as well as diminish the time of hospitalization which includes a specialized personal trainer in the health team. Moreover, this preventive strategy might improve patient recovery and would lead to consuming less resources of the health care system. This review included experimental studies in English and Portuguese found in SciELO and MEDLINE (from 1987 to 2008) and also classical texts related to the topic. Rev Bras Cir Cardiovasc 2009; 24(4): 552-561 Descriptors

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The Effect of Protease Inhibitor on Reperfusion Injury After Unilateral Pulmonary Ischemia

Cited by 18 publications

References 0 publications

Effects of Gabexate Mesilate (FOY) on Ischemia–Reperfusion-Induced Acute Lung Injury in Dogs

Effects of Gabexate Mesilate (FOY) on Ischemia–Reperfusion-Induced Acute Lung Injury in Dogs

The role of N-acetyl-cysteine in the lung remote injury after hepatic ischemia and reperfusion in rabbits

Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

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