Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

Delbin, Maria Andréia; Antunes, Edson; Zanesco, Angelina

doi:10.1590/s0102-76382009000500017

Cited by 9 publications

(4 citation statements)

References 66 publications

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“…Mild exercise training has demonstrated beneficial effects in preventing pulmonary IR injury (9) and is associated with the reduced mortality in ARDS (10). Limb remote ischemic preconditioning (RIPC), defined as intermittent periods of ischemia applied at a remote limb muscle before prolonged IR injury of a target organ, is a noninvasive intervention that has substantial benefits in protection against tissue injuries (11).…”

Section: Introductionmentioning

confidence: 99%

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

et al. 2017

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Limb remote ischemic preconditioning (RIPC) is an effective means of protection against ischemia/reperfusion (IR)–induced injury to multiple organs. Many studies are focused on identifying endocrine mechanisms that underlie the cross-talk between muscle and RIPC-mediated organ protection. We report that RIPC releases irisin, a myokine derived from the extracellular portion of fibronectin domain–containing 5 protein (FNDC5) in skeletal muscle, to protect against injury to the lung. Human patients with neonatal respiratory distress syndrome show reduced concentrations of irisin in the serum and increased irisin concentrations in the bronchoalveolar lavage fluid, suggesting transfer of irisin from circulation to the lung under physiologic stress. In mice, application of brief periods of ischemia preconditioning stimulates release of irisin into circulation and transfer of irisin to the lung subjected to IR injury. Irisin, via lipid raft–mediated endocytosis, enters alveolar cells and targets mitochondria. Interaction between irisin and mitochondrial uncoupling protein 2 (UCP2) allows for prevention of IR-induced oxidative stress and preservation of mitochondrial function. Animal model studies show that intravenous administration of exogenous irisin protects against IR-induced injury to the lung via improvement of mitochondrial function, whereas in UCP2-deficient mice or in the presence of a UCP2 inhibitor, the protective effect of irisin is compromised. These results demonstrate that irisin is a myokine that facilitates RIPC-mediated lung protection. Targeting the action of irisin in mitochondria presents a potential therapeutic intervention for pulmonary IR injury.

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Section: Introductionmentioning

confidence: 99%

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

et al. 2017

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“…Elderly'sparticipantsforwhomdancingisusuallypracticedasaleisureactivity (Delbin, 2004), were predominant within all analyzed studies in this review. The impactofdanceasleisureactivitiesanditscorrelationwithCADmaybeavariable toguidemoreresearch.Subjectsbehaviorfromallarticlesusedwithinourdiscussion demonstrated tolerance to dance classes, which may represent a possible scenario whenleadingwithfunctionallimitationsandpoorbasalphysicalconditioning.Since cardiopaths age, gender, social aspects are related to behavior and have impact on CAD(WHO,2018)itshouldbealsoconsideredonunderstandingindividualdance modalitychoicesandpermanencyduringarehabilitationprocess.…”

Section: Discussionmentioning

confidence: 99%

Dance as a Supplementary Instrument for Cardiac Rehabilitation

Urbano¹,

Marques²,

Milanez³

2018

International Journal of Art, Culture, Design, and Technology

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Intrinsic socio-cultural and motivational dance aspects, physical demands,general and styles characteristics, may promote positive influence on cardiac rehabilitation programs development and progression, if dance is approached as a supplementary activity and resource for cardiac patients. The aim of this study was to conduct an integrative literature review to evaluate dance as a supplementary activity on cardiac rehabilitation, considering physical demands, dance socio cultural aspects and regular practice related effects on cardiac patients' health and quality of life. Classical ballet and modern dance are not supported by this revision as appropriated alternatives to improve cardiovascular capacities for cardiopaths However, belly dance, ballroom dance, emphasis on Samba, Samkya showed multiple positive effects: glycemia levels reduction, resting heart rate reduction, cholesterol (HDL, LDL) and triglycerides level regulation, BP reduction, cardio respiratory increment and body relaxation.

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“…In addition to its preventive role, exercise training can even benefit patients already experiencing heart failure 269,270 and protect against damage from ischemia and reperfusion. 271 Improvements to vertebrate cardiac function following endurance training have been documented in both young and old animals. 272,273 The Drosophila model, due to its relatively short lifespan, offers an excellent opportunity to study the effects of age across ages in long-term, longitudinal study designs.…”

Section: Diet and Exercisementioning

confidence: 99%

Drosophila Models of Cardiac Disease

Piazza¹,

Wessells²

2011

Progress in Molecular Biology and Translational Science

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The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases, both developmental abnormalities and adult functional impairment. Using the tools of both classical and molecular genetics, the study of the developing fly heart has been instrumental in identifying the major signaling events of cardiac field formation, cardiomyocyte specification, and the formation of the functioning heart tube. The larval stage of fly cardiac development has become an important model system for testing isolated preparations of living hearts for the effects of biological and pharmacological compounds on cardiac activity. Meanwhile, the recent development of effective techniques to study adult cardiac performance in the fly has opened new uses for the Drosophila model system. The fly system is now being used to study long-term alterations in adult performance caused by factors such as diet, exercise, and normal aging. The fly is a unique and valuable system for the study of such complex, long-term interactions, as it is the only invertebrate genetic model system with a working heart developmentally homologous to the vertebrate heart. Thus, the fly model combines the advantages of invertebrate genetics (such as large populations, facile molecular genetic techniques, and short lifespan) with physiological measurement techniques that allow meaningful comparisons with data from vertebrate model systems. As such, the fly model is well situated to make important contributions to the understanding of complicated interactions between environmental factors and genetics in the long-term regulation of cardiac performance.

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Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

Cited by 9 publications

References 66 publications

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

Dance as a Supplementary Instrument for Cardiac Rehabilitation

Drosophila Models of Cardiac Disease

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