The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study

Abstract

Introduction Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries.Objective This study was carried to assess the effect of propolis administration in healing injured nasal mucosa in rats.Methods We randomly divided eighteen rats into three equal experimental groups: (1) non-treated group; (2) gum tragacanth (suspending agent for propolis) treated group; and (3) propolis treated group. The non-treated group received no treatment for 15 days. The second group received gum tragacanth administration (5 ml/kg, orally) once daily for 15 days. The third group received propolis suspension orally at a dose of 100 mg/kg once daily for 15 days. At the beginning of this study, we induced unilateral mechanical nasal trauma on the right nasal mucosa of all rats in the three groups using a brushing technique. A pathologist stained tissue samples using hematoxylin and examined eosin by using a light microscope.Results The severity of inflammation was milder with the absence of ulcerations in the propolis treated group compared with the non-treated and gum tragacanth groups. Goblet cell and ciliated cell loss was substantially lower in patients treated with propolis compared with groups without treatment and those treated with gum tragacanth.Conclusion Propolis decreased inflammation and enhanced healing of wounds of the nasal mucosa in rats.

Can Thermal Water Be an Alternative Treatment Method for Wound Healing?

“…The healing and disappear of ulcer can also show healing of wound (Fioravanti et al, 2011, El-Anwar et al, 2016. Although there was no statistically significant difference between groups in terms of ulcers in our findings, it appears that the ulcer has disappeared in the study group and in control group larger ulcers were numerically and proportionally more .…”

“…Wound and wound healing are important not only in terms of health and patient comfort, but also in terms of social and economic aspects (Woodfin et al, 2010 andEl-Anwar et al, 2016). Wounds can occur in a wide range including small wounds in the skin and mouth, major wounds which are large and occur due to chronic (wounds due to diabetes mellitus, Chronic bed wounds etc.)…”

Current and Alternative Therapies for Nasal Mucosa Injury: A Review

“…Synthesized by bees from plant resin, it has been demonstrated to have anti-inflammatory activity [57]. A study with rat models and nasal injury have revealed the reduction of inflammation and enhancement of healing of wounds of the nasal mucosa [58]. It has also been shown in a study that propolis reduces the severity of the inflammation and preserve both goblet cells and ciliary in nasal mucosa [58].…”

“…A study with rat models and nasal injury have revealed the reduction of inflammation and enhancement of healing of wounds of the nasal mucosa [58]. It has also been shown in a study that propolis reduces the severity of the inflammation and preserve both goblet cells and ciliary in nasal mucosa [58]. The exact mechanisms of nasal mucosa wound healing by propolis requires further study but its healing properties have been suggested to be due to its immune-stimulating effect where cytokine secretion capacity increases significantly during the treatment period in a time-dependent manner.…”

The Effects of Halofuginone on Wound Healing in the Rat Nasal Mucosa

“…The effects of several agents, such as hyaluronic acid, steroids, chitosan gel, and propolis, on the healing of sinonasal mucosa have been reported in previous studies. [3][4][5][6][7][8] However, an unmet need for new agents designed to eliminate problems such as adhesion and crust formation exists during the healing of mucosal damage caused by mechanical trauma induced by surgical procedures in the nose and paranasal sinuses.…”