The Effect of Prednisolone on the Serum Creatine Phosphokinase Response to Exercise

Wagner, J. A.; Critz, Jerry B.

doi:10.3181/00379727-128-33107

Cited by 25 publications

(11 citation statements)

References 4 publications

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“…The activities of serum creatine phosphokinase, inorganic phosphate, and lactate dehydrogenase in the systemic blood of pigs were examined before, during, and after indentations were inflicted on their thoracic paraspinal areas. Creatine phosphokinase is extremely sensitive to muscle damage (25) (16,17,26) have produced a number of studies gathering data from pressure wounds inflicted on hypotrichotic rats via a computer-controlled pressure delivery system. Their studies have validated the use of the laser Doppler flowmeter to measure muscle blood perfusion such that previous hypotheses suggesting muscle damage correlates with blood ischemia and tissue perfusion can be studied with pressure changes.…”

Section: Use Of Animal Models In Pressure Ulcer Research: Chronologicmentioning

confidence: 99%

Animal Models In Pressure Ulcer Research

Salcido

Popescu

Ahn

2007

The Journal of Spinal Cord Medicine

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Background/Objective: Research targeting the pathophysiology, prevention, and treatment of pressure ulcers (PrUs) continue to be a significant priority for clinical and basic science research. Spinal cord injury patients particularly benefit from PrU research, because the prevalence of chronic wounds in this category is increasing despite standardized medical care. Because of practical, ethical, and safety considerations, PrUs in the human environment are limited to studies involving patients with pre-existing ulcers. Therefore, we are limited in our basic knowledge pertaining to the development, progression, and healing environment in this devastating disease.Methods: This review provides a synopsis of literature and a discussion of techniques used to induce PrUs in animal models. The question of what animal model best mimics the human PrU environment has been a subject of debate by investigators, peer review panels, and editors. The similarities in wound development and healing in mammalian tissue make murine models a relevant model for understanding the causal factors as well as the wound healing elements. Although we are beginning to understand some of the mechanisms of PrU development, a key dilemma of what makes an apparently healthy tissue develop a PrU waits to be solved. Results and Conclusions:No single method of induction and exploring PrUs in animals can address all the aspects of the pathology of chronic wounds. Each model has its particular strengths and weaknesses. Certain types of models can selectively identify specific aspects of wound development, quantify the extent of lesions, and assess outcomes from interventions. The appropriate interpretation of these methods is significant for proper study design, an understanding of the results, and extrapolation to clinical relevance.

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Section: Use Of Animal Models In Pressure Ulcer Research: Chronologicmentioning

confidence: 99%

Animal Models In Pressure Ulcer Research

Salcido

Popescu

Ahn

2007

The Journal of Spinal Cord Medicine

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“…The mechanisms responsible for the exercise-induced increase in plasma enzyme activity have not been elucidated despite several studies related to this topic (6, 7). In particular, data obtained from experiments on the anaesthetized dog are difficult to assess since there is little information concerning the plasma enzyme response to exercise in the conscious dog (8,9). …”

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confidence: 99%

Changes in Plasma Enzyme Activity Elicited by Running Exercise in the Dog

Bolter¹,

Critz²

1974

Experimental Biology and Medicine

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“…A similar situation occurs with physical exercise, so it appears evident to attribute the increase in plasmatic enzymes to hypoxia. Hypoxia and tissue anoxia have often been used to explain the release of tissue enzymes in vivo or in vitro [6,34,36,43,51,60,72,84,87] in physiological or even pathological conditions. Figure 2 shows that all levels of hypoxia except that produced by 12% oxygen re------8 5 suited in an increase in CPK.…”

Section: Why Do We Observe Such Important Variations ?mentioning

confidence: 99%

Variations of Plasmatic Enzymes during Exercise

Siest¹,

Mm²

1974

Enzyme

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The authors have gathered from literature the variations of plasmatic enzymes during exercise in man. A vigorous program of prolonged exercise manifests itself by an increase in plasma enzymatic activities. However, many problems and questions arise from the considerable differences found in the literature. The authors try to answer these questions : where does the increase of plasma enzymatic activity originate from? Do the amounts of enzymes really increase? Do released enzymes always originate from muscles? Why do we observe such important variations? Why and how are enzymes released during physical exercise?

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The Effect of Prednisolone on the Serum Creatine Phosphokinase Response to Exercise

Cited by 25 publications

References 4 publications

Animal Models In Pressure Ulcer Research

Animal Models In Pressure Ulcer Research

Changes in Plasma Enzyme Activity Elicited by Running Exercise in the Dog

Variations of Plasmatic Enzymes during Exercise

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