Variations of Plasmatic Enzymes during Exercise

Siest, Gérard; Mm, Galteau

doi:10.1159/000459327

Cited by 14 publications

(8 citation statements)

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“…Thereby enzyme release from musele cells should contribute to the rnain part of elevated enzyme·activities in plasma (2), whereas other authors attribute rnpre impprtaijce to the liver (3,4). Further factors which can contribute to changes of enzyme activities in plasma are haemoconcentratjon (5), intravascular haemolysis (6,7), and the type, intensity (8) duration (2) and extent (9) of the work executed.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Transient Hypoxia in Skeletal Muscle on Enzyme Activities in Lymph and Plasma

Lindena¹,

Küpper²,

Trautschold³

1982

CCLM

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Lindena, Küpper and Träutschold: Skeletal muscle hypoxia and enzyme activities in lymph and plasma 95 J. Gin. Chem. Clin. Biochem. Vol. 20,1982, pp. 95-102 (Received July 7/October 21,1981) Summary: The effect of hypoxia lasting one hour on the hind leg muscle of anaesthetised dogs was investigated. Ten enzyme activities in plasma and leg lymph, and the lymphatic transport of these enzymes were investigated. Enzymes with high activity in muscle, like creatme kinase, lactate dehydrogenase, malate dehydrogenase and adenylate kinase only show an increase in the plasma, if lymph -propulsed by passive motion of the hind leg -can reach the intravascular space. This effect is independent of transient hypoxia. Depending on the level of enzyme activity in the muscle, the activity in leg lymph is up to 6-föld higher than in plasma. Enzymes from muscle have to be transported into the blood by lymph flow and not via a direct interstitial-venous entry. The results are discussed especially with respect to enzyme activity changes in plasma during physical exercise.

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Section: Introductionmentioning

confidence: 99%

“…During physical exertion inflow of interstitiäl fluid via ductus thoracicus into the blood rises several fold (14,15). 4. There are indications that due to the extremely low capillary permeäbility in skeletal muscle (16,17) macromolecules are transported predominantly via the lymphatics (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Effect of Transient Hypoxia in Skeletal Muscle on Enzyme Activities in Lymph and Plasma

Lindena¹,

Küpper²,

Trautschold³

1982

CCLM

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“…Other authors give animals the activities of most enzymes in serum more importance to the liver as a possible increase. Most authors attribute this to an source of released enzymes (8,24). Just recentenzyme release from muscle cells due to a ly Bolter and Critz (2) joined the still ongoing…”

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confidence: 99%

Lymphatic Transport of Cellular Enzymes from Muscle into the Intravascular Compartment

Lindena¹,

Küpper²,

Friedel³

et al. 1979

Enzyme

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In an experimental study, employing anaesthetized dogs, it was investigated whether cellular enzymes from peripheral skeletal muscle get into the circulating blood by diffusion across capillary membranes or by lymphatic transport. In the experimental group 1, the animals were anaesthetized only. The plasma activities of the four enzymes measured — lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, creatine kinase did not show any mentionable change during a time period of 6 h. In group 2 one hind limb of each animal was moved passively for 1 h. Alanine aminotransferase remained unchanged in plasma, the activities of the three other enzymes increased significantly. In group 3 one hind limb was made hypoxic by clamping the femoral blood vessels for 1 h. No activity changes were observed. When the period of hypoxia was followed by a 1-hour period of passive movement in group 4, the alterations in plasma activities were almost identical to those observed in group 2. In group 5 the experimental procedure was as in group 4, in addition the lymph from the thoracic duct was quantitatively withdrawn. The enzyme activities in plasma revealed a tendency to decrease rather than increase. Lymph flow increased significantly as well as the lymphatic activities of those enzymes which have high intracellular activities in muscle. The results prove, that enzymes from muscle are transported from the interstitial into the intravascular compartment mainly by lymphatic transport. Indications were found that the interruption of blood flow in one hind limb did not result in an enzyme release from muscle cells. It is discussed how changes in lymph flow, occurring during physical exercise for example, affect enzyme activities in plasma.

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“…Physical exercise has produced alterations in many enzyme systems in both human and animal studies (Schmidt and Schmidt, 1969;and Siest and Galteau, 1974). Several investigators have attempted to characterize the changes in plasma or serum enzyme activities which occur following exer cise.…”

Section: Review Of Literaturementioning

confidence: 99%

“…However, there has been a considerable amount of variability and contradiction in the published plasma enzyme responses to exercise. Some of the factors responsible for this variability have been demonstrated to be age, sex, diet, environmental temperature-physical training, altitude, hormones and pharmacological agents (Siest and Galteau, 1974). It is also difficult to compare results obtained with different species of animals or different types of exercise.…”

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confidence: 99%

Effects of age, training and exercise on plasma lactate dehydrogenase activity in male rats

Tuig

Gail²

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Variations of Plasmatic Enzymes during Exercise

Cited by 14 publications

References 54 publications

Effect of Transient Hypoxia in Skeletal Muscle on Enzyme Activities in Lymph and Plasma

Effect of Transient Hypoxia in Skeletal Muscle on Enzyme Activities in Lymph and Plasma

Lymphatic Transport of Cellular Enzymes from Muscle into the Intravascular Compartment

Effects of age, training and exercise on plasma lactate dehydrogenase activity in male rats

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