“…Lane et al (1990) reported that naproxen slowed bone formation in ovariectomized rats. Bichara et al (1999) showed that the post-surgical use of naproxen failed to produce osseous healing, which is in agreement with the present study. In earlier studies it was stated that the weakening effect of naproxen on fracture healing reduces the synthesis of prostaglandin by inhibiting the cyclooxygenase enzyme (Reuben and Connelly, 2000;Lipsky, 2001).…”