Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

İnal, Sermet; Kabay, Şahin; Çaycı, Muhammet Kasım; Kuru, Halil Isa; Altıkat, Sayit; Akkaş, Gizem; Deger, Aysenur

doi:10.1016/j.injury.2013.10.002

Cited by 26 publications

(17 citation statements)

References 42 publications

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“…Administraion of Mel alone significantly increases the liver and kidney body weight ratio. The increased AST and ALT in this study are agree with Inal et al, (2014) who mention that liver injury usually ranges from mild elevations of liver enzymes to occasionally severe hepatic failure on using NSAIDs (Mel). The kidney function (urea, & creatinine) with no changes.…”

Section: Resultssupporting

confidence: 91%

Ameliorative effects of Curcuma longa on methotrexate and meloxicam-induced hepatoxicity and nephrotoxity in rats

Raslan

Hassan

2017

Scientific Journal of October 6 University

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Methotrexate is widely used as chemotherapeutic agent in the treatment of malignancies and inflammatory diseases. Meloxicam is an analgesic and antipyretic drug. This study was carried out to determine if Curcuma longa has an ameliorative effect against Methotrexate and Meloxicam-induced toxicity in different organs in rats. Sprague-Dawley rats weighing 170±20gm were divided into six groups. Methotrexate and Meloxicam significantly increased serum AST, ALT, urea, and creatinine, liver & kidney body weight ratio as well as malondehyde and significant decrease in glutathione and superoxide dismutase when compared with control group. Administration of curcumin one hour before Methotrexate and Meloxicam significantly improved all the parameters mentioned before. The histopathological alterations confirmed the biochemical results. The data revealed that curcumin administration improved the liver and kidney histopathological lesions in rats treated with Methotrexate and Meloxicam. This study concluded that curcumin has a partial protective effect against the toxicity of Methotrexate and Meloxicam.

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Section: Resultssupporting

confidence: 91%

Ameliorative effects of Curcuma longa on methotrexate and meloxicam-induced hepatoxicity and nephrotoxity in rats

Raslan

Hassan

2017

Scientific Journal of October 6 University

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“…Results showed that diclofenac showed a dose-dependent inhibitory effect in the spinal fusion (r=0.271; p<0.001). In contrast, Inal et al, 13 found that diclofenac had no negative effect on osteoblast counts in peroneal fracture healing (67.14±14.96) compared with a control group (67.15±7.55); p=1.01.…”

Section: Discussionmentioning

confidence: 85%

Effects of NSAIDs and environmental oxygen pressure on bone regeneration.

et al. 2019

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Métodos: Participaron 36 cobayos distribuidos en dos grupos iguales. A ambos grupos se les realizaron defectos óseos mandibulares. El Grupo A fue controlado bajo presión de oxígeno en altura (3320msnm, 107mm Hg). El Grupo B fue controlado bajo presión de oxígeno a nivel del mar (150msnm, 157mm Hg). Cada grupo fue dividido en 3 subgrupos iguales (A1, A2, A3 y B1, B2, B3). Los subgrupos A1 y B1 recibieron diclofenaco; A2 y B2, ketoprofeno; A3 y B3, NaCl. La regeneración ósea fue evaluada histológicamente a los 15 y 30 días. Resultados: A nivel del mar, a los 15 días, hubo una significativa mayor cantidad de osteoblastos en el subgrupo control (28,00±2,65) comparado con el subgrupo diclofenaco (16,00±6.25) y ketoprofeno (18,00±4.36); (p=0,041). En altura, a los 15 días, hubo una significativa mayor cantidad de osteblastos en el subgrupo control (38,00±5,29) comparado con el subgrupo diclofenaco (21,67±6,35) y ketoprofeno (19,33±2,52); p=0,007. A nivel del mar, a los 30 días, no se encontró diferencia en el conteo celular; p>0,05. En altura, a los 30 días, se encontró una significativa mayor cantidad de osteoblastos en el subgrupo control (58,00±4,58) comparado con el subgrupo diclofenaco (34,33±4,73) y ketoprofeno (34,00±11,14); (p=0,003). Conclusión: La administración de diclofenaco y ketoprofeno produjeron una menor regeneración ósea mandibular, siendo este efecto significativamente más negativo a nivel del mar. Palabras Clave: Regeneración ósea; presión atmosférica; antiinflamatorios no esteroideos; hipoxia; factor 1 inducible por la hipoxia.

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“…Most studies that used rodents and rabbits demonstrated that non-selective and selective COX inhibitors impair the bone healing process (7, 9-12, 19, 24, 44, 52, 58, 63). Conversely, only a few studies indicated that NSAID has little or no effect on fracture healing outcomes (20,55,56,64). However, these studies have signi cant limitations, because they tested only one time point, did not measure clear bone healing outcomes that include mechanical or histomorphometric analysis, or used very low NSAID doses, and some did not perform a proper statistical analysis (42,65,66).…”

Section: Discussionmentioning

confidence: 99%

“…Several animal models including different animal strains, sex, and fracture techniques have been used to test the effect of types and administration durations of NSAID on bone healing outcomes (10,(18)(19)(20)(21)(22)(23)(24). The assessments of bone healing in these studies include integrated multilevel measurements at the organ (e.g., biomechanical to tissue levels using micro-computed tomography (µ-CT) analysis), cellular (e.g., histology, histomorphometric analysis), and gene (e.g., mRNA microarray to explain the associated healing pathway) levels (25,26).…”

Section: Introductionmentioning

confidence: 99%

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Al-Waeli

Reboucas²,

Mansour

et al. 2020

Preprint

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Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

Cited by 26 publications

References 42 publications

Ameliorative effects of Curcuma longa on methotrexate and meloxicam-induced hepatoxicity and nephrotoxity in rats

Ameliorative effects of Curcuma longa on methotrexate and meloxicam-induced hepatoxicity and nephrotoxity in rats

Effects of NSAIDs and environmental oxygen pressure on bone regeneration.

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

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