The effect of physical activity on serum IL-6 and vaspin levels in late elementary school children

Abstract

[Purpose]This study investigates the effects of physical activity on serum IL-6 and vaspin in late elementary school children.[Methods]Those who (n = 220) completed the 7-day physical activity monitoring underwent a second round of measurements including body fat, serum glucose and insulin, and serum IL-6 and vaspin. One way ANOVAs followed by LSD post hoc tests were used to test for significant differences in dependent variables across incremental physical activity levels at p=0.05. Multivariate stepwise linear regression analyses were used to determine significant predictors for serum IL-6 and vaspin levels at p=0.05.[Results]The results showed significant inverse linear trends for body fat parameters across incremental physical activity levels (from low to high); the lower the body fat, the higher the physical activity levels. On the other hand, there were no significant linear trends for insulin resistance markers or dietary intake across incremental physical activity levels. Multiple stepwise linear regression analyses were used to determine significant predictors for individual variations in serum IL-6 and vaspin in the study population. We found that body mass index (p=0.002) and low- and moderate-intensity physical activities (p=0.002 and p=0.0045, respectively) were significant determinants of serum IL-6. In addition, low- and moderate-intensity physical activities (p=0.01 & p=0.022, respectively) were significant determinants of serum vaspin levels in this study population.[Conclusion]In summary, the findings of the current study suggest that promotion of physical activity along with a healthy diet should be key components of lifestyle interventions to improve serum cytokine profiles associated with insulin resistance syndrome in late elementary school children.

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

“…Vaspin also decreased the expression of leptin, TNF-α, and resistin, so ameliorate in ammatory process that may effectively improve IR (10). In the present study, Keeping with previous research, vaspin associated significantly with hs-CRP and IL-6 in study participants (12, 28, 29, 30, 31). Inflammatory process amelioration may aid in impaired insulin sensitivity (25, 29).…”

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

“…Vaspin also decreased the expression of leptin, TNF-a, and resistin, so ameliorate in ammatory process that may effectively improve IR (10). In the present study, Keeping with previous research, vaspin associated significantly with hs-CRP and IL-6 in study participants (12,(28)(29)(30)(31). Inflammatory process amelioration may aid in impaired insulin sensitivity (25,29).…”

Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children

“…Possibly accounting for elevated IL-6 and TNFα, acute bouts of exercise (90 min) in elementary school children increased plasma IL-6 and TNFα by 125 ± 35% and 18 ± 7% respectively [ 31 ]. However, long-term increases in physical activity may relate to lower inflammatory cytokine concentrations in children [ 32 ], possibly due to lower adiposity [ 33 ]. In our cross-sectional study, though BMI z -score did not differ among vitamin D status categories, without measures of physical activity or adiposity, we are unable to control for these potential confounders.…”