Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Aliasghari, Fereshteh; Izadi, Azimeh; Jabbari, Masoumeh; Imani, Behzad; Gargari, Bahram Pourghassem; Asjodi, Foad; Ebrahimi, Sara

doi:10.2478/jomb-2018-0006

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…Izadi et al found that omentin-1 levels positively correlated with the NAFLD severity (29). In another study conducted by Aliasghari et al, serum omentin level was found to be high in patients with NAFLD (30). In this study, we found a correlation in the same direction between omentin-1 and BMI in obese adolescents with NAFLD.…”

Section: Discussionsupporting

confidence: 81%

Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents

et al. 2021

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Background: Omentin-1 is an adipocytokine secreted from visceral adipose tissue that is thought to increase insulin sensitivity. Non-alcoholic fatty liver disease (NAFLD) is a comparatively extensive problem in obese adolescents. Decreased omentin-1 levels have been reported in obese patients, but the relationship between NAFLD and omentin-1 is contradictory. Objectives: We aimed to evaluate the omentin-1 levels in the sera of obese adolescents with and without NAFLD and compare them with each other. Methods: In this study, a total of 88 adolescents (56 obese and 32 normal-weight) were enrolled. Abdominal ultrasonography (US) identified 28 obese adolescents with grade 2-3 hepatosteatosis constituting the NAFLD group and 28 without hepatosteatosis on US constituting the non-NAFLD group. The control group included 32 age- and gender-matched cases without hepatosteatosis and with normal percentile body mass index (BMI). Serum omentin-1 levels were evaluated and compared. Results: The mean age of the research group was 12.72 ± 1.91 years. Unsurprisingly, BMI, glycated hemoglobin (HbA1c), liver transaminases (AST, ALT), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin rates were noticeably elevated in obese adolescents compared to controls (P < 0.05). However, omentin-1 and high-density lipoprotein cholesterol (HDL) levels were remarkably lower in the obese group (P < 0.05). No significant difference was found between the NAFLD and non-NAFLD groups regarding omentin-1, HbA1c, glucose, urea, creatinine, AST, C-reactive protein (CRP), total cholesterol, triglyceride, HDL, LDL, thyroid stimulating hormone, 25-hydroxyvitamin D3, HOMA-IR, and insulin. The BMI and ALT grades of the non-NAFLD group were notably lower than the NAFLD group (P < 0.05). While there was no significant difference between omentin-1 and other parameters in obese adolescents without NAFLD (P > 0.05), we found a significant difference between omentin-1 and BMI, AST, ALT, HOMA-IR, and insulin values in obese adolescents with NAFLD (P < 0.05). Conclusions: Omentin-1 levels were decreased in obese adolescents regardless of the presence of NAFLD. However, in obese patients with NAFLD, there was a significant difference between omentin-1 and several markers of obesity and insulin resistance.

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Section: Discussionsupporting

confidence: 81%

Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents

et al. 2021

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“…Similarly, another study has confirmed that normal ALT activities were observed in 79% of subjects with hepatic steatosis (24). Although ALT exists in two isoforms in humans (25, 26), the ALT2 isoform makes the main contribution to homeostasis of free fatty acids (FFA), being highly expressed in adipose tissue of obese individuals (25). In addition, increased lipid peroxidation can cause the ALT to leak more easily out of the hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, increased lipid peroxidation can cause the ALT to leak more easily out of the hepatocytes. Moreover, it is assumed that increased ALT activity in circulation may also be a result of the compensatory response to the impaired hepatic insulin signalling (25).…”

Section: Discussionmentioning

confidence: 99%

Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population

Klisić

Kavarić

Ninić

2019

Journal of Medical Biochemistry

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Summary Background Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. Methods A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. Results ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P<0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P<0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P<0.001) in women. Conclusions Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.

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“…In contrast, there was a close relation between serum vaspin and insulin resistance in Japanese subjects (31), and insulin resistance has an influence on the correlations between changes in serum vaspin concentration (32). A significant positive correlation between vaspin and HOMA-IR was also seen in studies done in Iran (10,33).…”

Section: Discussionmentioning

confidence: 92%

Association of vaspin rs2236242 gene polymorphism with serum vaspin level, insulin resistance and diabetes in an Iranian diabetic/pre-diabetic population

Hosseini¹,

Nezhadali²,

Hedayati³

2021

J Med Biochemistry

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Background/aim: In recent years the role of vaspin as an insulin- sensitizer has been studied widely. This is the investigation that studied the association of vaspin polymorphism rs2236242 on vaspin level and the risk of type 2 diabetes and insulin resistant on pre-diabetic/ diabetic population. Material and method: A case-control study is conducted on 160 participants includes eighty participants holding (FBG) fasting blood glucose 70-100 (mg/dl) in normal group and eighty participants holding FBG≥100 (mg/dl) in diabetic/pre-diabetic group. The serum vaspin and insulin was determined with ELISA and biochemical variables by standard method. Tetra arms amplification system for vaspin gene was performed. Statistical analysis was done using SPSS software version 20. Results: The means of age, BMI, WC, HC, FBS and vaspin was significantly different between normal and T2DM/IFG group (P-value<0.05). rs2236242 showed association with Hip circumference (P-value<0.05). A significant association between allele A of rs2236242 with type 2 diabetes was seen (P-value<0.001). The vaspin level showed negative correlation with fasting blood glucose (FBG). Conclusions: Allele A of rs2236242 is a protective risk for type 2 diabetes but no association of rs2236242 with insulin resistant was seen. Lower level of vaspin is a predictor for progression of type 2 diabetes.

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Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Cited by 21 publications

References 40 publications

Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents

Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents

Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population

Association of vaspin rs2236242 gene polymorphism with serum vaspin level, insulin resistance and diabetes in an Iranian diabetic/pre-diabetic population

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