The Effect Of Phototherapy On Lymphocyte Subsets In Newborn Infants

Elfeky, Reem; Fattah, M. Abdel; Gaafar, D.M.; Afifi, Hanaa M.

doi:10.1016/j.jaci.2011.12.905

Cited by 3 publications

(3 citation statements)

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“…Eyada et al 22 also found no correlation among the levels of CD19, CD4, and CD8 in the lymphocytes of neonates after 72 hours of phototherapy, nor the occurrence of infections after a 6-month follow-up. Elfeky et al 23 found lower CD3 and CD19 levels after 72 hours of phototherapy and followed up these patients for 6 months. Patients with a higher CD3 decline had an increase in the number of hospital visits.…”

Section: Types Of Phototherapy Devicesmentioning

confidence: 98%

Side Effects of Phototherapy on Neonates

2018

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Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years. Through this review, we seek to analyze what we know about the side effects of phototherapy in the neonatal period. The main causes of jaundice, phototherapy techniques, acute and late side effects, and effects on the immune and inflammatory system were reviewed. It was concluded that phototherapy is not a treatment free of side effects and further studies need to be conducted to elucidate its harmful effects on neonates.

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Section: Types Of Phototherapy Devicesmentioning

confidence: 98%

Side Effects of Phototherapy on Neonates

2018

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“…22,23,24 The effect of phototherapy on oxidative stress and its effect on antioxidant/oxidant balance over a period of time after conventional, LED (Light emitting diode), and fiberoptic phototherapy have been investigated and shown that phototherapy is indicated to disrupt oxidant/antioxidant balance and induce oxidative stress. 25,26,28 Effect of phototherapy on oxidative stress and its effect on antioxidant/oxidant balance over a period of time after conventional, LED, and fiberoptic phototherapy have been investigated and shown that phototherapy is indicated to disrupt oxidant/antioxidant balance and induce oxidative stress. 25,26,28 According to American Academy of Pediatric (AAP) guidelines, intensive phototherapy is defined as the use of phototherapy with blue light (with a wavelength of 430-490 nm) delivered at 30 W/cm2/nm or more on the body surface.…”

Section: Intensive Phototeraphy In Neonatesmentioning

confidence: 99%

“…25,26,28 Effect of phototherapy on oxidative stress and its effect on antioxidant/oxidant balance over a period of time after conventional, LED, and fiberoptic phototherapy have been investigated and shown that phototherapy is indicated to disrupt oxidant/antioxidant balance and induce oxidative stress. 25,26,28 According to American Academy of Pediatric (AAP) guidelines, intensive phototherapy is defined as the use of phototherapy with blue light (with a wavelength of 430-490 nm) delivered at 30 W/cm2/nm or more on the body surface. The dual phototherapy model is also known as intensive phototherapy which is given to neonates who experience a very rapid increase in serum bilirubin.…”

Section: Intensive Phototeraphy In Neonatesmentioning

confidence: 99%

Intensive phototherapy as the initial management of severe hyperbilirubinemia in neonates

Dinatha¹,

Utomo²,

Setyoboedi³

2022

ijhs

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Hyperbilirubinemia is one of the most common clinical phenomena found in newborns, which is about 60% of term infants and 80% of preterm infants in the first week of life. Severe hyperbilirubinemia can cause encephalopathy and permanent neurodevelopmental damage with an incidence that varies between 4% - 60.3% and mortality rate of 13% to 56.8% worldwide. Phototherapy and exchange transfusion are therapeutic modalities for infants with severe hyperbilirubinemia. Intensive phototherapy has fewer side effects and can reduce the need for exchange transfusion. This treatment is rarely needed if intensive phototherapy is effective, current guidelines for the management of hyperbilirubinemia focus on the use of intensive phototherapy as initial treatment. This literature review aims to discuss intensive phototherapy as the initial management of severe hyperbilirubinemia in neonates.

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Immunoglobulin G Levels in Neonates After Receiving Phototherapy

Mirnia,

Saeedi,

Sangsari

et al. 2023

Iran J Pediatr

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Background: Most cases of newborn hyperbilirubinemia are physiologic; however, excessive unconjugated bilirubin is a potential neurotoxin. Phototherapy treats moderate to severe hyperbilirubinemia. If phototherapy increases immunoglobulin G (IgG) clearance, there is a chance of humoral immune disorders. Objectives: The purpose of the study was to investigate the effect of phototherapy on the level of IgG in neonates. Methods: This study investigated 40 full-term newborns with hyperbilirubinemia. Blood samples were taken before and 72 hours after phototherapy. The IgG level was measured by calorimetry tests. Results: Phototherapy resulted in a decrease in IgG levels. The IgG level significantly decreased from 833.135 to 720.185 mg/dL. Before phototherapy, 12.5% of the population had low IgG levels; however, 32.5% had low IgG levels after the treatment. Conclusions: According to the results of the study, intensive phototherapy caused a reduction in IgG levels. Since there was no significant decrease in IgG levels in neonates who received conventional phototherapy, it can be concluded that this treatment is safe in terms of IgG levels.

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The Effect Of Phototherapy On Lymphocyte Subsets In Newborn Infants

Cited by 3 publications

References 0 publications

Side Effects of Phototherapy on Neonates

Side Effects of Phototherapy on Neonates

Intensive phototherapy as the initial management of severe hyperbilirubinemia in neonates

Immunoglobulin G Levels in Neonates After Receiving Phototherapy

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