The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

Doaei, Saeid; Gholami, Somayeh; Rastgoo, Samira; Gholamalizadeh, Maryam; Bourbour, Fatemeh; Bagheri, Seyedeh Elaheh; Samipoor, Forough; Akbari, Mohammad Esmail; Shadnoush, Mahdi; Ghorat, Fereshteh; Jarrahi, Seyed Alireza Mosavi; Mirsadeghi, Narjes Ashouri; Hajipour, Azadeh; Joola, Parvin; Moslem, Alireza; Goodarzi, Mark O.

doi:10.1186/s12967-021-02795-5

Cited by 144 publications

(149 citation statements)

References 45 publications

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“…Omega-3 fatty acids have anti-inflammatory and immunomodulatory properties [67,68] and were tested in several recent trials in patients suffering from COVID-19. A higher omega-3 index was associated with a lower risk of death from COVID-19 [69], as well as with improvements in several parameters of respiratory and renal function in critically ill COVID-19 patients [70]. Moreover, omega-3 fatty acids have been suggested to strengthen psychological resilience during the COVID-19 pandemic [71].…”

Section: Fatty Acids Mental Health and Covid-19mentioning

confidence: 96%

Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets

Storz

2021

Curr Nutr Rep

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Purpose of Review The SARS-CoV-2-pandemic has caused mortality and morbidity at an unprecedented global scale. Many patients infected with SARS-CoV-2 continue to experience symptoms after the acute phase of infection and report fatigue, sleep difficulties, anxiety, and depression as well as arthralgia and muscle weakness. Summarized under the umbrella term “long-COVID,” these symptoms may last weeks to months and impose a substantial burden on affected individuals. Dietary approaches to tackle these complications have received comparably little attention. Although plant-based diets in particular were shown to exert benefits on underlying conditions linked to poor COVID-19 outcomes, their role with regard to COVID-19 sequelae is yet largely unknown. Thus, this review sought to investigate whether a plant-based diet could reduce the burden of long-COVID. Recent Findings The number of clinical trials investigating the role of plant-based nutrition in COVID-19 prevention and management is currently limited. Yet, there is evidence from pre-pandemic observational and clinical studies that a plant-based diet may be of general benefit with regard to several clinical conditions that can also be found in individuals with COVID-19. These include anxiety, depression, sleep disorders, and musculoskeletal pain. Adoption of a plant-based diet leads to a reduced intake in pro-inflammatory mediators and could be one accessible strategy to tackle long-COVID associated prolonged systemic inflammation. Summary Plant-based diets may be of general benefit with regard to some of the most commonly found COVID-19 sequelae. Additional trials investigating which plant-based eating patterns confer the greatest benefit in the battle against long-COVID are urgently warranted.

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Section: Fatty Acids Mental Health and Covid-19mentioning

confidence: 96%

Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets

Storz

2021

Curr Nutr Rep

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“…An observational study reported that a higher omega-3 index, EPA+DHA as a percentage of total erythrocyte fatty acids, was inversely associated with risk of death in 100 hospitalized COVID-19 patients ( 101 ). Results of a pilot study of EPA+DHA supplementation ( 102 ) and a case report of icosapent ethyl treatment ( 103 ) in COVID-19 patients also suggest benefit, and additional prospective clinical trials are ongoing ( Table ).…”

Section: Lipids In Regulating the Immune Response To Viral Infectionmentioning

confidence: 99%

The roles of lipids in SARS-CoV-2 viral replication and the host immune response

Theken¹,

Tang²,

Sengupta³

et al. 2021

Journal of Lipid Research

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The significant morbidity and mortality associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has underscored the need for novel antiviral strategies. Lipids play essential roles in the viral life cycle. The lipid composition of cell membranes can influence viral entry by mediating fusion or affecting receptor conformation. Upon infection, viruses can reprogram cellular metabolism to remodel lipid membranes and fuel the production of new virions. Further, several classes of lipid mediators, including eicosanoids and sphingolipids, can regulate the host immune response to viral infection. Here we summarize the existing literature on the mechanisms through which these lipid mediators may regulate viral burden in COVID-19. Further, we define the gaps in knowledge and identify the core areas in which lipids offer therapeutic promise for SARS-CoV-2.

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“…Several clinical trials assessing the effect of omega-3 PUFAs in COVID-19 management are currently registered (ZPD37). In a recent double-blind, randomized clinical trial, enteral supplementation with omega-3 PUFAs significantly improved respiratory and renal function indices as well as one-month survival rates in critically ill patients with COVID-19 [ 111 ].…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19

2021

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There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising pharmacological targets. At the same time, nutritional modulation of immune system function has been proposed and is being investigated for the prevention of COVID-19 or as an adjunctive strategy combined with conventional therapy. Several studies indicate that several immunonutrients can regulate mast cell activity to reduce the de novo synthesis and/or release of histamine and other mediators that are considered to mediate, at least in part, the complex pathophysiology present in COVID-19. This review summarizes the effects on mast cell histamine of common immunonutrients that have been investigated for use in COVID-19.

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The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

Cited by 144 publications

References 45 publications

Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets

Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets

The roles of lipids in SARS-CoV-2 viral replication and the host immune response

The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19

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