The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19

Kakavas, Sotirios; Karayiannis, Dimitrios; Mastora, Zafeiria

doi:10.3390/nu13103458

Cited by 9 publications

(9 citation statements)

References 150 publications

(180 reference statements)

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“…In these studies, both ascorbic acid and pyridoxine reduced the serum concentration of histamine in allergic patients or suppressed the release of histamine from isolated mast cells. Concerning the mechanisms, ascorbic acid was considered to prevent the formation of histamine or facilitate its degradation [29,30]. However, besides histamine, mast cells release other chemical mediators, such as leukotrienes or β-hexosaminidase, and produce various types of inflammatory cytokines or growth factors [8].…”

Section: Discussionmentioning

confidence: 99%

Pyridoxine Synergistically Potentiates Mast Cell-Stabilizing Property of Ascorbic Acid

2022

Cell Physiol Biochem

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Background/Aims: Besides their physiological properties, vitamins, such as vitamin C (ascorbic acid) and B6 (pyridoxine), ameliorate the symptoms of allergic disorders. Because exocytosis in mast cells can be detected electrophysiologically by the changes in the membrane capacitance (Cm), its continuous monitoring in the presence of these vitamins would determine their mast cell-stabilizing, anti-allergic properties. Methods: Employing the whole-cell patch-clamp technique in rat peritoneal mast cells, we examined the effects of ascorbic acid and pyridoxine on the degranulation of mast cells and the increase in the Cm during exocytosis. Results: Both ascorbic acid and pyridoxine dose-dependently suppressed the GTP-γ-S-induced increase in the Cm and inhibited the degranulation from mast cells. Surprisingly enough, relatively low concentrations of pyridoxine (1, 2 mM) synergistically enhanced the suppressive effect of 2 mM ascorbic acid on mast cell degranulation. Conclusion: These results provided electrophysiological evidence for the first time that ascorbic acid and pyridoxine inhibited the process of exocytosis in a dose-dependent manner. At relatively lower concentrations, these vitamins were not enough to stabilize mast cells. However, such concentrations of pyridoxine synergistically potentiated the mast cell-stabilizing property of ascorbic acid.

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Section: Discussionmentioning

confidence: 99%

Pyridoxine Synergistically Potentiates Mast Cell-Stabilizing Property of Ascorbic Acid

2022

Cell Physiol Biochem

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“…This is because vitamin D binds to the gene transcription apparatus to regulate the gene expression of selected mediators, like TNF-α [ 27 ]. Moreover, mast cell proliferation, secretion, and survival can be inhibited by vitamin E supplementation [ 28 ], and vitamin B reduces phospholipase A-induced mast cell degranulation by limiting histamine release from cells [ 29 ]. Nevertheless, supplementation with vitamins should be strictly controlled as their too-high levels may have a negative influence on the body.…”

Section: Mast Cells Degranulation and Its Inhibitorsmentioning

confidence: 99%

Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches

Baran

Sobiepanek

Mazurkiewicz-Pisarek

et al. 2023

Cells

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Mast cells (MCs) are the immune cells distributed throughout nearly all tissues, mainly in the skin, near blood vessels and lymph vessels, nerves, lungs, and the intestines. Although MCs are essential to the healthy immune response, their overactivity and pathological states can lead to numerous health hazards. The side effect of mast cell activity is usually caused by degranulation. It can be triggered by immunological factors, such as immunoglobulins, lymphocytes, or antigen–antibody complexes, and non-immune factors, such as radiation and pathogens. An intensive reaction of mast cells can even lead to anaphylaxis, one of the most life-threatening allergic reactions. What is more, mast cells play a role in the tumor microenvironment by modulating various events of tumor biology, such as cell proliferation and survival, angiogenesis, invasiveness, and metastasis. The mechanisms of the mast cell actions are still poorly understood, making it difficult to develop therapies for their pathological condition. This review focuses on the possible therapies targeting mast cell degranulation, anaphylaxis, and MC-derived tumors.

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“…Examples of mast cell stabilizers are flavonoids: these are a large group of natural stabilizers, including luteolin, apigenin, kaempferol, fisetin, quercetin, genistein, and epigallocatechin gallate. Some antihistamine drugs have also shown anti-inflammatory and mast cell-stabilizing effects such as olopatadine, rupatadine, and ketotifen [40,[42][43][44].…”

Section: Management Of Patients With Post-covid Syndrome and After Ef...mentioning

confidence: 99%

Post-COVID Syndrome: The Research Progress in the Treatment of Pulmonary sequelae after COVID-19 Infection

et al. 2022

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Post-COVID syndrome or long COVID is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection, the pathogen responsible for coronavirus disease. The content herein presented reviews the reported long-term consequences and aftereffects of COVID-19 infection and the potential strategies to adopt for their management. Recent studies have shown that severe forms of COVID-19 can progress into acute respiratory distress syndrome (ARDS), a predisposing factor of pulmonary fibrosis that can irreversibly compromise respiratory function. Considering that the most serious complications are observed in the airways, the inhalation delivery of drugs directly to the lungs should be preferred, since it allows to lower the dose and systemic side effects. Although further studies are needed to optimize these techniques, recent studies have also shown the importance of in vitro models to recreate the SARS-CoV-2 infection and study its sequelae. The information reported suggests the necessity to develop new inhalation therapies in order to improve the quality of life of patients who suffer from this condition.

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The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19

Cited by 9 publications

References 150 publications

Pyridoxine Synergistically Potentiates Mast Cell-Stabilizing Property of Ascorbic Acid

Pyridoxine Synergistically Potentiates Mast Cell-Stabilizing Property of Ascorbic Acid

Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches

Post-COVID Syndrome: The Research Progress in the Treatment of Pulmonary sequelae after COVID-19 Infection

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