The effect of metal particles from a nickel refinery dump on alveolar macrophages. Part 2—environmental exposure of rabbits

Effects of pollutant atmospheres on surface receptors of pulmonary macrophages

“…Reichrtova et al (1986) have demonstrated similar impairment of antibody-mediated rosette formation with pulmonary macrophages from rabbits on exposure to nickel downwind from a refinery dump site. The inhibition of Fc receptors on peritoneal macrophages was also reported with circulating immune complexes (Rao et al, 1979b).…”

“…Hadley et al (1977) have shown that inhaled toxic substances can impair FcR activity (ability to fix cytophilic antibody on the surface of macrophages). Inhalation exposure to nickel (Reichrtova et al, 1986) and in vitro exposure to lead Qian et al, 1985) have been shown to cause an inhibitory effect on FcR activity. The purpose of our studies was to compare the effects of the two multicomponent atmospheres on the FcR activity of pulmonary macrophages, and to shed light on the sensitivity of this assay in detecting pollutant-related lung injury.…”

Toxic Effects of Short-Term Exposures to Acids and Diesel Exhaust

“…Schiff et al, (1979) (Fenters et al, 1979 (Brain, 1986;Herscowitz, 1985;Bienenstock, 1984 (Johnston et al, 1985). Inhalation exposure to nickel (Reichrtova et al, 1986), and in vitro exposure to lead (Jian et al, 1985) have been shown to cause an inhibitory effect on FcR activity (ability to fix cytophillic antibody on the surface of macrophages). In addition,…”