Monitoring of Air Pollutant Effects, Some Principles and Examples

Reichrtová, E

doi:10.1007/978-3-642-79316-5_4

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…We have published results regarding biomarkers of exposure, impairment of tracheal mucosa, and immunotoxic effects related to heavy metals contained in the ambient air particulates using the animal model (42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds

Reichrtová¹,

Čižnár²,

Prachar³

et al. 1999

Environmental Health Perspectives

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Allergic diseases are on the rise in both prevalence and severity, especially in industrialized countries. The process of allergic sensitization needs an understanding of the role environmental factors play in its development. In addition to traditionally considered air pollutants, various persistent organochlorine pollutants, which accumulate in the human body over a lifetime via food intake, are toxic in humans. Placental contamination by cecals may act as a biologic marker for the exposure of the mother or for the fetus via transplacental transfer. Placentas were collected from term deliveries in two Slovak regions. The samples were then analyzed for 21 selected organochlorine compounds. Specimens of cord blood from 2,050 neonates were gathered for the determination of levels of total immunoglobulin E (IgE). The regions were chosen according to their environmental ca istics: a city polluted with organic chemical industry versus a rural region devoid of industrial sources of pollution. In addition, data regarding the incidence rate of atopic eczema cases in the regions were considered. Comparisons between regions revealed that both the placental contamination with 16 of 21 organochlorine compounds and the cord serum IgE levels were significandy higher in the industrial region. The findings pointed to an association between organochlorine compounds and the higher leves oftotal IgE in newborns, signaling a higher allergic sensitization in the industrial region. This association was supported by the higher incidence rate of atopic e czmases in the population regstered in the industrial region. Key work allergy, atopic eczema, biomarkers, ,congeners of polychlorinated biphenyls, cord serum immunoglobulin E, human placenta, organochlorine compounds, sensitization. Environ Healtb

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Section: Discussionmentioning

confidence: 99%

Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds

Reichrtová¹,

Čižnár²,

Prachar³

et al. 1999

Environmental Health Perspectives

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Sites of lead and nickel accumulation in the placental tissue

Reichrtová

Dorociak²,

Palkovičová

1998

Hum Exp Toxicol

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1 There is a variety of quantitative analytical data regarding the total concentrations of heavy metals in human placentae. However, little is known about sites of metal accumulation in the placental tissue structural zones in relation to the environment. In this study, the lead and the nickel particulate deposits in the placental chorionic plate, the chorionic villous tree and the basal plate, using tissue histochemical reactions for lead and nickel, have been estimated. The degree of metal contamination of placentae was assessed according to an arbitrary scale. Both metals have shown a common mode of accumulation in the placental tissue structural zones. Among the observed contaminated structures in the placental tissue, the syncytiotrophoblast was the most frequent site for lead and nickel particulate deposits. 2 The frequency distribution of both metals within the mentioned placental zones, using four metal contamination degrees, was determined. A heavily contaminated zone was found to be the chorionic villous tree, especially in samples from the industrial region. 3 A comparison between two Slovak regions (an industrial and a rural one) using statistical tests was performed. The frequency of samples without any lead occurrence in the chorionic villous tree was found to be 10% in the industrial region, and 16% in the rural region. Regarding the nickel deposits, the frequency of non-contaminated samples in the industrial region was 2%, whereas in the rural region 6%. A relationship between traffic related pollution and human placenta contamination was found in both investigated regions.

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Monitoring of Air Pollutant Effects, Some Principles and Examples

Cited by 2 publications

References 6 publications

Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds

Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds

Sites of lead and nickel accumulation in the placental tissue

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