The effect of lower body weight support on arterial wave reflection in healthy adults

Afzal, Atif; Fung, Daniel; Galligan, Sean; Godwin, Ellen M.; Kral, John G.; Salciccioli, Louis; Lazar, Jason

doi:10.1016/j.jash.2014.03.004

Cited by 3 publications

(4 citation statements)

References 40 publications

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“…Also, whereas cardiac autonomic imbalance is deranged during the progression of CHF and dysautonomia improved by exercise, LBPP might portend beneficial effects owing to increased parasympathetic tone. Of note, weight support evokes a number of cardio-respiratory changes as a consequence of increased intra-thoracic blood volume and lower extremity compression, including augmenting venous return, increasing stroke volume and baroreceptor activation [3,9]. The patient remained stable and was able to begin a conventional walking program suggesting that weight supported treadmill ambulation may be useful as a bridge to unsupported exercise.…”

Section: Discussionmentioning

confidence: 97%

“…Lower body positive pressure (LBPP) treadmills have recently become widely available to the recreational community. In general, such systems consist of a computer-controlled treadmill equipped with a pressurized air chamber that generates a vertical upward force directly opposing the force of gravity and effectively decreasing body weight [3]. The airtight chamber is formed by the user wearing neoprene shorts that zip around the waist, creating a kayak type skirt from the waist down.…”

Section: Discussionmentioning

confidence: 99%

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Weight Supported Treadmill Ambulation in a Patient with Severe Congestive Heart Failure: A Case Report

Yuri

Siddiqui

2018

BJSTR

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We describe a 43-year old man with congestive heart failure (CHF) with markedly reduced ejection fraction and New York Heart Association Class 3 to 4 symptoms. After a 6-minute walk test showed a 140 m distance, he performed 6 weeks of walking sessions on a weight-supporting lower body positive pressure treadmill (LBPP). Unloading 40% of his body weight he was able to progressively increase the duration of the walking sessions, exhibited a post-session diuretic effect and dramatically increased his exercise capacity on a 6-minute walk test. He rated his satisfaction with the sessions as maximal. His functional class improved to class 2, remaining stable at 1-year follow-up. We conclude that repeated sessions of ambulation on a weight-supporting LBPP treadmill may benefit patients with CHF with reduced ejection fraction and poor functional capacity.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Weight Supported Treadmill Ambulation in a Patient with Severe Congestive Heart Failure: A Case Report

Yuri

Siddiqui

2018

BJSTR

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“…Our heterodox findings of improved glucoregulation with triglyceride decrease, mild effects on cytokines and adipokines but a robust effect on the orexigenic peptide ghrelin in the absence of weight loss accompanying brief, ambulation raises questions about putative mechanisms. We speculate that improvements in substrate utilization such as glucose disposal, lipolysis or “protein sparing” are not likely to be primary determinants, but rather synergistic with autonomic nervous system activation/conditioning (“stress buffering”) [17] and/or release of key molecules through mild compression and use of lower extremity muscles known to have beneficial cardiovascular [50, 51], angiogenic and metabolic effects associated with restored autonomic balance.…”

Section: Discussionmentioning

confidence: 99%

A pilot study of metabolic fitness effects of weight-supported walking in women with obesity

et al. 2019

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Background This is an exploratory pilot study of novel technology enabling people with mobility disability to walk with minimal effort, in the “sedentary range”. The study’s premise is that impairment of the leading physical activity of daily living, walking, is a major contributor to a dysmetabolic state driving many prevalent “civilization diseases” associated with insulin resistance. Methods We explore within-subject changes in standard oral glucose tolerance (OGT) tests including metabotropic molecules after 22 twice-weekly, 30-minute bouts of weight-supported light-moderate physical activity in 16 non-diabetic obese, otherwise healthy, reproductive-age, volunteer women walking on an “anti-gravity” lower-body positive pressure (LBPP) treadmill. Results Subjects had reference base-line fasting plasma glucose and triglycerides (TG) but 2-hr OGT insulin levels of 467 ± 276 pmol • liter -1 (mean± S.D.) indicating nascent insulin resistance, compared to post-study 308 ± 179 (p = 0.002). Fasting TG decreased from 0.80 ± 0.30 mmol • liter -1 to 0.71 ± 0.25 (p = 0.03). Concomitantly plasma total ghrelin decreased from 69.6 ± 41.6 pmol • liter -1 to 56.0 ± 41.3 (p = 0.008). There were no statistically significant changes in body weight or any correlations between weight change and cardiometabolic markers. However, there were robust positive correlations between changes among different classes of peptides including C-reactive protein–Interleukin 6, leptin–adiponectin, β-endorphin–oxytocin and orexin A (r 2 = 0.48–0.88). Conclusion We conclude that brief, low-dose physical activity, walking on an anti-gravity LBPP treadmill may improve cardiometabolic risk, exhibiting favorable changes in neuro-regulatory peptides without weight loss in people with problems walking.

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“…Our heterodox findings of improved glucoregulation with triglyceride decrease, mild effects on cytokines and adipokines but a robust effect on the orexigenic peptide ghrelin in the absence of weight loss accompanying brief, low-intensity exertion, raises questions about putative mechanisms. We speculate that improvements in substrate utilization such as glucose disposal, lipolysis or "protein sparing" are unlikely to be primary determinants but rather synergistic with autonomic nervous system activation/conditioning ("stress buffering") [2] and/or release of key molecules through mild compression and use of lower extremity muscles known to have beneficial cardiovascular [42,43], angiogenic and metabolic effects associated with restored autonomic balance.…”

Section: Neuro-endocrine Peptidesmentioning

confidence: 99%

Cardio- and neurometabolic effects of lower-body pressure-supported exercise in obese non-diabetic women: Resetting autonomic imbalance?

Godwin

Uglialoro

Ali

et al. 2017

Preprint

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The effect of lower body weight support on arterial wave reflection in healthy adults

Cited by 3 publications

References 40 publications

Weight Supported Treadmill Ambulation in a Patient with Severe Congestive Heart Failure: A Case Report

Weight Supported Treadmill Ambulation in a Patient with Severe Congestive Heart Failure: A Case Report

A pilot study of metabolic fitness effects of weight-supported walking in women with obesity

Cardio- and neurometabolic effects of lower-body pressure-supported exercise in obese non-diabetic women: Resetting autonomic imbalance?

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