The effect of long-chain polyunsaturated fatty acids intake during pregnancy on adiposity of healthy full-term offspring at birth

Pereira‐da‐Silva, Luís; Cabo, C; Moreira, Ana Catarina; Papoila, Ana Luísa; Virella, Daniel; Neves, Rute; Bridges, Kayla M.; Cordeiro-Ferreira, Gonçalo

doi:10.1038/jp.2014.188

Cited by 12 publications

(8 citation statements)

References 39 publications

(67 reference statements)

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“…47 Nested within the same aforementioned cross-sectional study on 100 mother-infant pairs, the adjusted effect of longchain polyunsaturated fatty acid (LCPUFA) intake during pregnancy on the adiposity of offspring was also evaluated early after birth. 31 Positive associations were found between maternal docosahexaenoic acid intake and birth size in male offspring (β=0.165; 95% CI; 0.031 -0.299, p = 0.017), and between n-6 : n-3 LCPUFA ratio intake and adiposity in female offspring (β = 0.636; 95% CI; 0.125 -1.147, p = 0.016). 31 The association between offspring adiposity and maternal LCPUFA ratio intake favoring n-6 over n-3 LCPUFA is in coherence with the reported adipogenic effect of n-6 fatty acids family and anti-adipogenic effect of n-3 fatty acids family.…”

mentioning

confidence: 95%

“…Two national official surveys on food availability including women of childbearing age, 19,20 seven national studies on the diet and nutritional status of women of childbearing age and pregnant women [21][22][23][24][25][26][27] and five national studies on the effect of maternal factors on their growing fetuses [28][29][30][31][32] were analyzed.…”

Section: Selected Studiesmentioning

confidence: 99%

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Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions

Pereira‐da‐Silva

Pinto

2016

Acta Med Port

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Introduction: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritional status of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed. Material and Methods: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring. Results: Data from five multinational ecological studies that included Portugal, two national official surveys on food availability, seven national studies on the diet and nutritional status of women of childbearing age and pregnant women, and five national studies on the effect of nutritional maternal factors on their growing fetuses were selected and analyzed. The prevalence of overweight/obesity has dramatically increased in Portuguese women of childbearing age and pregnant women, associated with the described trend of low adherence to Mediterranean diet. Variations in energy and macronutrients intakes during pregnancy seem to have no significantly impact on the nutritional status of growing fetuses. On contrary, pre-pregnancy overweight/obesity has been associated with increased offspring adiposity at birth, and an excessive gestational weight gain may be associated with offspring's overweight status in childhood.Factors potentially contributing to low adherence to the Mediterranean diet, deserving further investigation, include European Union agriculture policies that have implemented the production of non-Mediterranean food groups at low cost, and insufficient financial capacity to afford foods of quality reported by Portuguese population. Material e Métodos:Realizámos uma revisão narrativa crítica de estudos recentes com qualidade e inquéritos nacionais oficiais, que tivessem avaliado a dieta e estado de nutrição de mulheres em idade fértil e de grávidas portuguesas e sua influência no estado de nutrição dos respetivos fetos e recém-nascidos. Resultados:Foram selecionados e analisados cinco estudos ecológicos multinacionais que incluíram Portugal, dois inquéritos oficiais nacionais sobre disponibilidade de alimentos, sete estudos nacionais sobre dieta e estado de nutrição de mulheres em idade fértil e grávidas e cinco estudos nacionais sobre a influência de fatores nutricionais maternos no crescimento dos fetos. A prevalência de excesso de peso/obesidade em mulheres em idade fértil e grávidas aumentou substancialmente associada à diminuição da adesão à dieta mediterrânica. As variações no consumo de energia e macronutrientes na gravidez parecem não ter impacto significativo no estado de nutrição dos fetos. Pelo contrário, o excesso de peso/obesidade pré-concecional associa-se a aumento de adiposidade ao nascer e o excessivo aumento de peso na gravidez associa-se ao excesso ponderal na infância. Os fatores potencialmente relacionados com a baixa adesão à dieta mediterrânica, merecendo futura inves...

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confidence: 95%

Section: Selected Studiesmentioning

confidence: 99%

Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions

Pereira‐da‐Silva

Pinto

2016

Acta Med Port

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“… 5 Moreover, n-3 LCPUFAs strongly affect fetal body composition. 6 Furthermore, a study conducted in Hong Kong reported that an average maternal consumption of 450 g of seafood per week during pregnancy could increase the IQ in the offspring. 7 …”

Section: Introductionmentioning

confidence: 99%

Maternal seafood intake and the risk of small for gestational age newborns: a case–control study in Spanish women

et al. 2018

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ObjectiveTo investigate the relationship between seafood consumption during pregnancy and the risk of delivering a small for gestational age (SGA) newborn.DesignThis case–control study included women with SGA newborns and controls matched 1:1 for maternal age (±2 years) and hospital.SettingFive hospitals in Eastern Andalusia, Spain.Participants518 pairs of pregnant Spanish women. The SGA group included women who delivered SGA newborns: SGA was defined as a birth weight below the 10th percentile of infants at a given gestational age. Controls were women who delivered newborns with adequate birth weights.InterventionsWe collected data on demographic characteristics, socioeconomic status, toxic habits and diet. Midwives administered a 137-item Food Frequency Questionnaire.Outcome measuresWe calculated quintiles of seafood intake and applied conditional logistic regression to estimate ORs and 95% CIs.ResultsShellfish intake more than once/week yielded a significant protective effect against an SGA newborn (OR 0.25, 95% CI 0.08 to 0.76, after adjusting for energy, educational level, smoking, prepregnancy body mass index, weight and a history of preterm or low birthweight newborn). The risk of an SGA newborn was lower among women who consumed >29 g/day fish compared with women who consumed ≤8 g (adjusted OR 0.63, 95% CI 0.41 to 0.98; p=0.025 for a trend). Similarly, the risk of an SGA newborn was lower among women who consumed >1 g/day of marine n-3 polyunsaturated fatty acids compared with those who consumed ≤0.4 g/day (adjusted OR 0.58, 95% CI 0.38 to 0.90; p=0.025 for a trend).ConclusionAn average seafood intake of at least 29 g/day during pregnancy, equivalent to 2–3 servings/week, reduced the risk of an SGA newborn, compared with an average seafood intake of less than 8 g/day.

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“…( 1 – 6 ) However, BW alone does not indicate an infant’s body composition (e.g., percent body fat), which may be a better predictor for adult-onset chronic diseases. ( 7 , 8 ) Preclinical studies have consistently shown correlations between high-fat maternal diets during pregnancy, altered fetal body composition, and metabolic syndrome in the offspring. The syndrome is characterized by insulin resistance, hypertension, dyslipidemia, and increased central adiposity.…”

Section: Introductionmentioning

confidence: 99%

Maternal dietary fat intake during pregnancy and newborn body composition

et al. 2021

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Objective Increased infant birth weight and adiposity are associated with altered risk of adult chronic diseases. The objective was to investigate the association between maternal dietary fat intake during pregnancy and newborn adiposity. Study Design The study included 79 singleton pregnancies. Associations between maternal dietary fat intake during each trimester and infant adiposity at birth were assessed. Result Average total grams of maternal total dietary fat and unsaturated fat intake during pregnancy correlated with infant percent body fat after adjusting for potential confounding variables ( r =0.23, p=0.045; r =0.24, p=0.037). Maternal average daily intake of total fat, saturated fat, and unsaturated fat during the second trimester of pregnancy were each associated with infant percent body fat ( r =0.25, p=0.029; r =0.23, p=0.046; r =0.25, p=0.031; respectively). Conclusion The second trimester of pregnancy is a key time period for fetal adipose tissue metabolic programming and therefore a target for nutritional intervention.

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The effect of long-chain polyunsaturated fatty acids intake during pregnancy on adiposity of healthy full-term offspring at birth

Cited by 12 publications

References 39 publications

Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions

Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions

Maternal seafood intake and the risk of small for gestational age newborns: a case–control study in Spanish women

Maternal dietary fat intake during pregnancy and newborn body composition

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