The effect of local injection of botulinum toxin A on the immunoreactivity of nNOS in the rat submandibular gland: An immunohistochemical study

Ellies, Maik; Schütz, Sebastian; Quondamatteo, Fabio; Laskawi, R.

doi:10.1016/j.ijporl.2005.05.015

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…Currently, experimental studies of the action of botulinum toxin in salivary glands follow a pattern, in rats, and the majority refers to immunohistochemical studies. Immunohistochemical investigations were made mainly for the enzyme acetylcholinesterase (AChE) and neuronal nitric oxide synthase (nNOS) in submandibular and/or parotid glands of female rats, such as publications of Ellies et al (1999Ellies et al ( , 2000Ellies et al ( , 2003Ellies et al ( , 2006a and Ellies (2003).…”

Section: Discussionmentioning

confidence: 99%

“…Nitric oxide acts as a possible vascular neuromodulator in the regulation of specific secretory processes in the upper aerodigestive tract (Ellies et al, 2006a). The enzyme neuronal nitric oxide synthase is an important marker of nerve terminals in salivary glands (Chiba and Tanaka, 1998;Takai et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The enzyme neuronal nitric oxide synthase is an important marker of nerve terminals in salivary glands (Chiba and Tanaka, 1998;Takai et al, 1999). Thus, besides acetylcholine transmitters, other neurotransmitters, such as NO neuromodulator may also be involved in regulating the function of the salivary gland (Ellies et al, , 2006a. Ellies et al (1999Ellies et al ( , 2000Ellies et al ( , 2003Ellies et al ( , 2006a and Ellies (2003), tested the immunoreactivity for acetylcholinesterase and neuronal nitric oxide synthase in parotid and submandibular glands of female rats and demonstrated weak immunoreactivity for these enzymes in the groups treated with botulinum toxin, becoming proportional with the increase of the time exposure to the toxin.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, besides acetylcholine transmitters, other neurotransmitters, such as NO neuromodulator may also be involved in regulating the function of the salivary gland (Ellies et al, , 2006a. Ellies et al (1999Ellies et al ( , 2000Ellies et al ( , 2003Ellies et al ( , 2006a and Ellies (2003), tested the immunoreactivity for acetylcholinesterase and neuronal nitric oxide synthase in parotid and submandibular glands of female rats and demonstrated weak immunoreactivity for these enzymes in the groups treated with botulinum toxin, becoming proportional with the increase of the time exposure to the toxin. According to histological studies in submandibular glands of female rats made by Ellies et al (1999), there is no clear difference of serous acini of glands injected with the toxin and saline in their histometric measurements, although both had a slightly higher nuclear counting than in the acini control group.…”

Section: Discussionmentioning

confidence: 99%

“…Anticholinergic drug substances such as Atropine, Benztropine, Glycopyrrolate, and Benzhexol Hydrochloride are some options, which reduce the volume of saliva in the oral cavity by blocking the action of parasympathetic autonomic nervous system on acetylcholine receptors on the salivary glands (Ellies et al, 2006a;Coskun et al, 2007;Bavikatte et al, 2012). Other ways include antihistaminic drugs (Alter, 2010); surgery such as ablation of salivary glands, tympanic neurectomy, transposition or retropositioning of excretory ducts or ligation of excretory ducts (Ellies et al, 2002;Savarese et al, 2004;Manrique et al, 2007); radiotherapy (Bavikatte et al, 2012;Kasarskis et al, 2011;Corso et al, 2011); speech therapy (Crysdale, 1980); techniques of body position, and the "biofeedback" (Tscheng, 2002;Savarese et al, 2004;Bloem et al, 2009;Valencia and Mendoza, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

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The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS). Inclusion and exclusion criteria for articles were established, and a total number of 14 articles were selected and used. There are few publications that clarify how the salivary gland acini behave with application of botulinum toxin. Although, the immunohistochemical findings were consistent among authors, showing weak immunoreactivity in glands treated with botulinum toxin. Histometric data are divergent, requiring more detailed studies to answer the questions about the efficacy and safety of botulinum toxin in salivary glands.Keywords: botulinum toxins, salivary glands, sialorrhea, botulinum toxin type A.Achados histológicos e imunohistoquímicos da ação da toxina botulínica em glândula salivar: revisão sistemática ResumoO tratamento da sialorreia se faz necessário pelos constantes riscos trazidos por este estado de hipersalivação. Uma nova opção terapêutica surge com a aplicação da toxina botulínica em glândulas salivares. Entretanto, pouco se sabe sobre o seu mecanismo de ação no tecido glandular. Com base no exposto, este trabalho teve o objetivo de revisar sistematicamente na literatura a ação da toxina botulínica sobre o tecido das glândulas salivares submandibular e parótida. Foi realizada uma busca eletrônica em bases de dados de grande relevância para este estudo (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS e IBECS). Foram estabelecidos critérios de inclusão e exclusão para os artigos, e um "n" de 14 trabalhos foram selecionados e utilizados. São poucas as publicações que esclarecem como os ácinos das glândulas salivares se comportam mediante aplicação da toxina botulínica. Apesar de os achados imunohistoquímicos entre os autores serem concordantes, com imunorreatividade mais fracas nas glândulas tratadas com a toxina botulínica, os dados histométricos são divergentes e há questionamentos metodológicos, necessitando de mais estudos pormenorizados para responder as questões sobre a eficácia e segurança da toxina botulínica nas glândulas salivares.Palavras-chave: toxinas botulínicas, glândulas salivares, sialorreia, toxinas botulínicas tipo A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

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Botulinum Toxin Treatment in Dentistry

Lora

Cury

2020

Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

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Efeito da toxina botulínica tipo A sobre a expressão de neuropeptídeos e o transporte mucociliar nasal em coelhos

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À minha esposa Marcela Camera Carreirão Nada disso seria possível sem você. Minha companheira, minha fiel escudeira, meu AMOR. Sua compreensão e apoio incondicional durante todas as etapas desta tese foram fundamentais para nosso sucesso. Esta vitória também é sua e ela só tem significado porque tenho você ao meu lado. Aos meus pais Waldir Carreirão Filho e Margareth Ferreira Carreirão Vocês são a origem de tudo. Toda minha formação moral e ética devo a vocês. Isto, aliado a todo o amor que sempre recebi me fizeram uma pessoa melhor. Amo vocês. Ao meu irmão Eduardo Carreirão Não há nesse mundo melhor exemplo de "anjo na forma de pessoa". Quem tem o privilégio do seu convívio sabe do que estou falando. Amo você meu irmão. Ao meu irmão Marcelo Carreirão Foram anos de afastamento por causa de nossa formação médica. Mas ao mesmo tempo, sempre estivemos ligados por nossa amizade. Agora, finalmente juntos... meu companheiro... meu melhor amigo... À minha segunda mãe Maria Aparecida da Silva Foi Deus que colocou você em nossa família. É praticamente impossível descrever com palavras toda dedicação e amor que recebemos de você e que sentimos por você. "Obrigado Cidinha..." Aos meus avós Lygia Ferreira Nascimento (in memoriam)

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The effect of local injection of botulinum toxin A on the immunoreactivity of nNOS in the rat submandibular gland: An immunohistochemical study

Cited by 4 publications

References 20 publications

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

Botulinum Toxin Treatment in Dentistry

Efeito da toxina botulínica tipo A sobre a expressão de neuropeptídeos e o transporte mucociliar nasal em coelhos

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