The effect of local administration of N-acetylcysteine in perforated rat tympanic membrane: an experimental study in myringosclerosis

Özcan, Cengiz; Polat, Gürbüz; Görür, Kemal; Talaş, Derya Ümit; Bagdatoglu, Ozlen; Cinel, İsmail

doi:10.1006/phrs.2001.0906

Cited by 22 publications

(30 citation statements)

References 41 publications

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“…ALA may be beneficial in preventing the development of MS by affecting the release of serum inflammatory cytokines-in other words, showing an anti-inflammatory effect [11,15,31] . In many previous studies, the beneficial effects of anti-inflammatory agents on MS have been shown [6,21,26,27,32] . In most of the experimental studies on myringosclerosis, histological and otomicroscopic evaluations were preferred.…”

Section: Discussionmentioning

confidence: 97%

“…Many hypotheses have been proposed to explain the MS formation process. The most accepted view is that the increase in the production of oxygen free radicals and insufficient antioxidant defense mechanisms may lead to the development of MS when a hyperoxic environment occurs in the middle ear [3,4,6] .…”

Section: Discussionmentioning

confidence: 99%

“…After the revelation of the role of oxygen free radicals in the pathogenesis of MS, thanks especially to the study of Mattson et al [21] , many studies showed that this damage, caused by oxygen free radicals, could be successfully reduced or prevented by using antioxidant, free radical connective substances and anti-inflammatory agents that have been reported in the literature. Of these, ascorbic acid, vitamin E, selenium, L-carnitine, N-acetylcysteine , caffeic acid, ginkgo biloba, pomegranate, N-nitro L-arginine, steroids, and melatonin can be considered [6,17,[21][22][23][24][25][26][27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported that in the event of a defect in the tympanic membrane, an increase in the concentration of oxygen in the middle ear results in a rise in the amount of ROS, which leads to MS [3,4] . In addition, the additive effect of ROS on myringosclerosis was detected in myringotomized rats [6] . Ferlito [7] reported that TS was strictly connected to inflammation and that it was the end product of inflammation, in spite of the severity of TS changes in the type of inflammation (serous, mucous, and purulent inflammation).…”

Section: Introductionmentioning

confidence: 90%

“…In addition, a genetic predisposition, immunological sensitivity, and local metabolic changes are factors that predispose a person to the development of TS [3][4][5] . Although the etiopathogenesis of MS is not fully understood, recent studies have reported that reactive oxygen samples (ROS), mechanical injury, and inflammatory diseases are the main factors in the development of MS, and antioxidant agents, free radical connective substances, and anti-inflammatory agents are effective in preventing MS [4,6] . Some studies reported that in the event of a defect in the tympanic membrane, an increase in the concentration of oxygen in the middle ear results in a rise in the amount of ROS, which leads to MS [3,4] .…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Tatar¹,

Yörük²,

Ünal³

et al. 2015

Int Adv Otol

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OBJECTIVE: Alpha-lipoic acid (ALA) is an anti-inflammatory and antioxidant agent. In this study, the effects of ALA on the development of myringosclerosis in myringotomized rats were investigated. MATERIALS and METHODS:The rats were studied in five groups: each group included 6 rats (for a total of 30 rats). After a myringotomy was performed, the groups were administered a 25-mg/kg/day and 50-mg/kg/day dose of ALA for 15 days. The eardrums of the rats were examined histopathologically. We made the histopathological assessment from 0 to 3 on a 4-point scale by scoring the degree of the histopathological changes. In addition, superoxide dismutase, malondialdehyde, and glutathione peroxidase levels were measured in blood samples taken from the rats. RESULTS:In histopathological examinations, a high dose (50 mg/kg/day) of the ALA-applied group had histopathological results similar to those of the healthy group. In this group, we detected minimal collagen deposition, slight thickness in the lamina propria, and minimal epithelial disruption. In biochemical examinations, the maximum values of superoxide dismutase and glutathione peroxidase were observed in the group that received 50 mg/kg/day of ALA. CONCLUSION:In this study, the effect of ALA on myringosclerosis development was observed when a dose of 50 mg/kg/day was administered, and a recovery that showed a nearly intact tympanic membrane occurred at the end of 15 days of use. If an antioxidant were to be added to the treatment protocol of tympanic membrane defects, ALA may be a good candidate.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Tatar¹,

Yörük²,

Ünal³

et al. 2015

Int Adv Otol

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Protective effect of L‐carnitine on renal ischaemia–reperfusion injury in the rat

Görür

Bagdatoglu

Polat

2004

Cell Biochemistry & Function

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This study was designed to investigate the effect of L-carnitine in ischaemia and reperfusion of the rat kidney. Rats were randomly allocated into three groups. Group I (control group; n = 6) received no treatment. Group II (isotonic saline group; n = 6), received 2 ml of isotonic saline 15 min before the renal ischaemia, and group III (carnitine group; n = 6) received L-carnitine hydrochloride (100 mg kg(-1)) intraperitoneally. At the end of the reperfusion period, rats were sacrificed. Tissue malondialdehyde level (MDA), myeloperoxidase (MPO) activity, and nitrite/nitrate (NO) level of renal tissue were measured to evaluate the lipid peroxidation, neutrophil function, and nitric oxide metabolism, respectively. The tissue levels of MDA, MPO and NO were lower in group III (71.8 +/- 8.4, 172.1 +/- 27.4 U g(-1) tissue, 76.3 +/- 29.7 micromol l(-1) respectively) than levels in groups I (103.4 +/- 13.4 nmol g(-1), 325.9 +/- 20.2 U g(-1) tissue, 144.5 +/- 39.2 micromol l(-1), respectively) and II (103.5 +/- 11.4 nmol g(-1), 317.1 +/- 41.5 U g(-1) tissue, 148.9 +/- 23.9 micromol l(-1), respectively). It is shown that carnitine protects kidney tissue against ischaemia-reperfusion injury.

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Lipid peroxidation and some antioxidant enzymes in nasal polyp tissue

Taysı

Uslu

Yılmaz

et al. 2006

Cell Biochem. Funct.

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Nasal polyp (NP) is considered an inflammatory condition in nasal and paranasal sinus cavities and is frequently encountered in otolaryngology clinics. Although the pathophysiology of nasal polyps is poorly understood, it seems likely that the epithelium may play a critical role in the genesis of inflammatory nasal disease. The aim of this study was to investigate the role of free radicals and antioxidant enzymes in NP and compare these findings with concha bullosa (CB). NP and CB were obtained from 27 and 23 patients, respectively. Glutathione peroxidase (GSH-Px), catalase (CAT), xanthine oxidase (XO) total (enzymic plus non-enzymic) superoxide scavenger activity (TSSA), non-enzymic superoxide scavenger activity (NSSA), superoxide dismutase (SOD), and MDA levels in NP and CB were measured. GSH-Px activiy was significantly lower in patients with NP than in the CB group. However, CAT, XO activities and MDA levels were significantly higher in patients with NP than in the CB group, but TSSA, NSSA and SOD activities were unchanged. Increases in the levels of tissue MDA in patients with NP compared to the CB group may indicate the presence of free radical damage in patients with nasal NP.

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The effect of local administration of N-acetylcysteine in perforated rat tympanic membrane: an experimental study in myringosclerosis

Cited by 22 publications

References 41 publications

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Protective effect of L‐carnitine on renal ischaemia–reperfusion injury in the rat

Lipid peroxidation and some antioxidant enzymes in nasal polyp tissue

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