The Effect of Ionizing Radiation on Multi-drug Resistant Pseudomonas aeruginosa Isolated from Aquatic Environments in Egypt

Ezzat, Safaa M.; Abo-State, Mervat Aly Mohamed; Mahdy, H. M.; El-Shakour, E. H. A.; Elbahnasawy, Mostafa A.

doi:10.9734/bmrj/2014/7606

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…On behalf of previously mentioned data it was clear that, pollution levels indicated from bacteriological analyses play an important role in the incidence of antibiotics resistant bacteria in water environment and that dissemination of these bacteria depends on pollution extents. The same conclusion was reported by Graham et al (2011); Abo-State et al (2012); Ezzat et al (2014) who found that, unregulated pollution sources including pharmaceutical wastes, inadequate domestic treatment and large landfill have the potential of magnifying the problem.…”

Section: In Vitro Virulence Abilitysupporting

confidence: 76%

Antibiotics resistance phenomenon and virulence ability in bacteria from water environment

et al. 2017

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This study aims to determine the impact of five main drains as sources of antibiotics resistant bacteria in River Nile at Rosetta branch, and to generate a baseline data on their virulence ability. Out of 212 bacterial isolates, 39.2% and 60.8% were recovered from drains and Rosetta branch, respectively. Susceptibility of bacteria to different antibiotics showed multiple antibiotics resistances (MAR) for the majority of isolates. Meanwhile, sensitivity was mostly directed to ofloxacin and norfloxacin antibiotics. Calculated MAR index values (>0.25) classified area of study as potentially health risk environment. Testing virulence ability of bacteria from drains showed positive results (65%). Contrastively, virulent strains in Rosetta branch were mostly lacking in this study. Concluding remarks justify the strong correlation (r = +0.82) between MAR and virulence of bacteria in polluted aquatic ecosystems, and highlight the potential of drains as reactors for their amplification and dissemination. The study suggests regular monitoring for antibiotics resistance in native bacteria of River Nile, prohibition of unregulated use of antibiotics, and proper management for wastes disposal.

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Section: In Vitro Virulence Abilitysupporting

confidence: 76%

Antibiotics resistance phenomenon and virulence ability in bacteria from water environment

et al. 2017

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“…Eight samples were collected from Delta Barrage-El-Kanater El-Khayria (used as a reference point); drinking water plant is called El-Qanater El-Khayria, which serves as main fresh water supply for drinking water production (four samples: surface and bottom water from inlet and outlet) and for three drinking water tanks from Bahada, Baradah, and Shlqan (distribution water network) as shown in Table 1. River Nile at Rosetta branch was subdivided into five reaches based on locations of known waste inputs (Ezzat et al, 2014) as illustrated in Fig. 1.…”

Section: Study Areamentioning

confidence: 99%

Aquatic environmental monitoring and removal efficiency of detergents

El-Gawad

2014

Water Science

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In this study, the detergent's concentrations in aquatic environment principally drinking and surface water along River Nile and near rural village were determined to report the influence of different physicochemical characteristics on the distribution of linear alkylbenzene sulfonate (LAS) that lead to toxicity in human beings. The removal efficiency of LAS using zeolite and granular activated carbon technique was assessed.The results showed wide variations observed between surface (0.07-0.38 mg LAS/l) and bottom water (0.05-0.17 mg LAS/l) due to increase in population density and human activities that recorded highest concentration along rural area (surface: 1.24-2.45 and bottom: 0.93-1.083 mg LAS/l). Low concentration of surfactants was found in drinking water (0.005-0.007 mg LAS/l) compared to the concentration of the corresponding water samples along the River Nile. In conclusion, the study indicated that the treatment processes for drinking water production were insufficient for the complete removal of surfactants and adsorption process by using zeolite as low cost, most beneficial, economically feasible method as well as easy to operate for producing high quality of water.

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“…The emergence and dissemination of antimicrobial-resistant bacteria pose a challenge to the conventional antibiotics used in various clinical practices. This has led to considerable public health concerns and demands for alternative treatments ( Ezat et al, 2014 ). Along with this, more than 80% of microbial infections are generally biofilm-based.…”

Section: Introductionmentioning

confidence: 99%

Isolation of quinic acid from dropped Citrus reticulata Blanco fruits: its derivatization, antibacterial potential, docking studies, and ADMET profiling

Heena,

Kaushal,

Kaur

et al. 2024

Front. Chem.

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Citrus reticulata dropped fruits are generally discarded as waste, causing environmental pollution and losses to farmers. In the present study, column chromatography has been used to isolate quinic acid (1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid) from the ethyl acetate fraction of a methanol extract of citrus fruits dropped in April. Quinic acid is a ubiquitous plant metabolite found in various plants and microorganisms. It is an important precursor in the biosynthesis of aromatic natural compounds. It was further derivatized into 3,4-o-isopropylidenequinic acid 1,5-lactone (QA1), 1,3,4,5-tetraacetoxycyclohexylaceticanhydride (QA2), and cyclohexane-1,2,3,5-tetraone (QA3). These compounds were further tested for their antibacterial potential against the foodborne pathogens Staphylococcus aureus, Bacillus spp., Yersinia enterocolitica, and Escherichia coli. QA1 exhibited maximum antibacterial potential (minimum inhibitory concentration; 80–120 μg/mL). QA1 revealed synergistic behavior with streptomycin against all the tested bacterial strains having a fractional inhibitory concentration index ranging from 0.29 to 0.37. It also caused a significant increase in cell constituent release in all the tested bacteria compared to the control, along with prominent biofilm reduction. The results obtained were further checked with computational studies that revealed the best docking score of QA1 (−6.30 kcal/mol, −5.8 kcal/mol, and −4.70 kcal/mol) against β-lactamase, DNA gyrase, and transpeptidase, respectively. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis revealed that the drug-like properties of QA1 had an ideal toxicity profile, making it a suitable candidate for the development of antimicrobial drugs.

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The Effect of Ionizing Radiation on Multi-drug Resistant Pseudomonas aeruginosa Isolated from Aquatic Environments in Egypt

Cited by 10 publications

References 18 publications

Antibiotics resistance phenomenon and virulence ability in bacteria from water environment

Antibiotics resistance phenomenon and virulence ability in bacteria from water environment

Aquatic environmental monitoring and removal efficiency of detergents

Isolation of quinic acid from dropped Citrus reticulata Blanco fruits: its derivatization, antibacterial potential, docking studies, and ADMET profiling

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