The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Abstract

BackgroundCurcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.MethodsSeven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group – 1 mg/100 g body weight (bw), NTG+ST+CC2 – 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group – 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group – 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.ResultsThe plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.ConclusionLiposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.

Headache occurring during rehabilitation in a migrainous patient with cervical spinal cord injury

“…Our patient presented with bradycardia, so the use of beta-blockers for migraine prophylaxis was inappropriate. According to our recent research, curcumin was shown to be effective in migraine prophylaxis (13) and in migraine attacks due to its important anti-inflammatory effects (14), being also well tolerated by patients. Patients with spinal cord injury need long recovery periods.…”

Evaluation of oxidative stress in migraine patients with visual aura - the experience of an Rehabilitation Hospital

“…Based on the accumulating evidence that endogenous NO regulation is altered in migraine pathogenesis, global and isoform-selective inhibitors of NOS have been targeted for migraine drug development [25]. It is also involved in nociceptive processing by inducing cephalic hyperalgesia that arises as a consequence of central sensitization in pain pathways that sub serve to meningeal nociception [27].Combination of natural compounds as is Curcumin can improve the nociception modulation and decrease the NO level when added to Sumatriptan treatment in experimental migraine [17]. Migraine is a risk factor for the formation of silent brain white matter lesions (WMLs) that are possibly ischemic in nature.…”

“…Comorbidities associated with migraine were also assessed: obesity assessed by body mass index (BMI), dysplipidemias (assessed by LDL-cholesterol, HDL-cholesterol, triglycerides), inflammatory parameters (C reactive protein and fibrinogen), smoking, alcohol consumption and hypertension. Nitro-oxidative stress leading to endothelial dysfunction was assessed as nitric oxide synthesis expressed as NOx [16,17]. MDA was assessed according with the method described by Yagl [18].…”

Effect of Liposomal Curcumin on Acetaminophen Hepatotoxicity by Down-regulation of Oxidative Stress and Matrix Metalloproteinases

“…Substances. Liposomal curcumin was encapsulated in longcirculating liposomes at a concentration of 4.7 mg/ml, using the film hydration method with a lipid molar ratio of 9.5:0.5:1 (1,2dipalmitoyl-sn-glycero-3-phosphocholine:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]-DPPC:PEG-2000-DSPE:CHO) as previously described (35,36). The proposed formulation had appropriate quality attributes for i.p.…”