Effect of Liposomal Curcumin on Acetaminophen Hepatotoxicity by Down-regulation of Oxidative Stress and Matrix Metalloproteinases

Abstract

Background/Aim: The hepatoprotective role of various molecules in drug-induced hepatotoxicity arouses great interest. We investigated the effect of liposomal curcumin (LCC) on experimental acetaminophen (APAP)-induced hepatotoxicity. Materials and Methods: Rats were randomly allocated into 5 groups, and the effect of two LCC concentrations was studied: group 1 -1 ml intraperitoneal (i.p.) saline, group 2 -APAP pretreatment, group 3 -APAP+silymarin (extract of the silybum marianum with anti-inflammatory, anti-oxidant, and anti-fibrotic properties), group 4 -APAP+LCC1, group 5 -APAP+LCC2. The biomarkers of oxidative stress (nitric oxide and malondialdehyde) and antioxidant status of plasma (thiols and catalase), TNF-α, MMP-2 and MMP-9 serum levels were evaluated. Results: An improvement in oxidative stress, antioxidant status, and TNF-α, MMP-2 and MMP-9 levels was obtained in groups pretreated with LCC compared to silymarin treatment, in a dose-dependent manner. Histopathological examination reinforced the results. Conclusion: Liposomal curcumin improves the oxidative stress/antioxidant balance and alleviates inflammation in experimental APAP-induced hepatotoxicity.

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

“…The first experiment related to therapeutic impact of curcumin was published in 1937 ( Zhou et al, 2011 ), and since then, much attention has been directed toward revealing the extraordinary pharmacological activities of curcumin. It has been reported that curcumin has valuable therapeutic and biological activities such as antioxidant ( Kharat et al, 2020 ), anti-inflammatory ( Sneharani, 2019 ), anti-diabetic ( Xia et al, 2020 ), hepatoprotective ( Dogaru et al, 2020 ), cardioprotective ( Hadi et al, 2019 ; Hallajzadeh et al, 2019 ; Kuszewski et al, 2019 ), neuroprotective ( Sturzu et al, 2019 ), anti-microbial ( Rai et al, 2020 ), anti-tumor ( Bahrami et al, 2019 ; Shabaninejad et al, 2020 ; Weng and Goel, 2020 ) and improving dyslipidemia ( Roxo et al, 2019 ) and ischemic-reperfusion ( Ahmed et al, 2019 ). Curcumin possesses great solubility in oil-based solutions.…”

The Induction of Antioxidant Catalase Enzyme With Decrease of Plasma Malonidialdehyde: An Important Reactive Oxidative Species Inhibiting Mechanism

“…(19). In addition, MDA is used as a biomarker of acetaminophen hepatotoxicity (20) and to identify ROS changes of bladder tissue in the initial phase of diabetes (16). Tsounapi et al (16) showed that MDA levels in the bladder wall were significantly higher in the diabetes group compared to other study groups.…”

The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

“…However, these investigations still did not cover most of the famous nanosystems. For instance, curcumin-loaded polymerized graphene oxide nanocarrier was reported to improve its sustained release behavior and bioavailability with a cytocompatible profile [ 291 ], while curcumin liposomes were reported to improve the oxidative stress/antioxidant balance and alleviate inflammation in experimental acetaminophen-induced hepatotoxicity [ 292 ]. Studying the impact of such nanosystems on MAFLD might grant answers to many questions concerning its generic drugs (anti-obesity, hypoglycemic, lipid-lowering, cytoprotective and antioxidant agents), and phytomedicinal therapies.…”