The Effect of Intraoperative Mebendazole-Albendazole Applications on the Hepatobiliary System

Abstract

Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1 % albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal.

Praziquantel-Dymethylsuifoxide Solution: The Side Effect on Hepato-biliary System (An Experimental Study)

“…Properties of an ideal protoscolocidal solution would be the absence of local and systemic adverse effects together with a complete and rapid scolex killing. Although the side effects of protoscolicidal solutions such as formalin, ethyl alcohol, hypertonic saline, cetrimide, Ag NO3, polyvinyl pyrolidone iodure, and hydrogene peroxide, have been commonly investigated and shown, there is not a concensus for ideal protoscolicidal solutions [8,11,12,14]. We have shown that albendazole solution is one of the most effective protoscolocidal with no side effect on hepatobiliary system [14,15].…”

“…Although the side effects of protoscolicidal solutions such as formalin, ethyl alcohol, hypertonic saline, cetrimide, Ag NO3, polyvinyl pyrolidone iodure, and hydrogene peroxide, have been commonly investigated and shown, there is not a concensus for ideal protoscolicidal solutions [8,11,12,14]. We have shown that albendazole solution is one of the most effective protoscolocidal with no side effect on hepatobiliary system [14,15]. At present the most commonly used protoscolicidal agents are 95-98 % ethyl alcohol and 20 % NaCI.…”

“…These findings, of a milder degree have been reported after alcohol and hypertonic NaCI solutions. Hydrogen peroxide and cetrimide have similar but lesser side effects [8][9][10]12,14,[16][17][18][19]. After alcohol injection, minimal conjestion, mild hydropic degeneration, mild subepithelial biliary fibrosis, proliferation of the bile canaliculi, periductal inflammation and focal necrosis have been reported [11].…”

Comparison of the Protoscolocidal Effectiveness of Hypertonic Saline, Povidone—Iodine and Albendazole Solutions in an Experimental Lung Hydatid Cyst Model

“…20,21 Hydatid cysts present an important economic problem for such countries. 2,8,22,23 Imaging methods that detect spaceoccupying lesions are important in the diagnosis of hydatid cysts, and serological tests, such as the IHA test, are used for confirmation when radiology and the clinical picture suggest these infections. …”

Instillation of Hypertonic Glucose into Gall Bladder of Rabbit: Does it Induce Sclerosing Cholangitis?

“…The most common surgical procedure is evacuation of t h e cyst and *Corresponding author: Tel: +98-711-2293004; Fax: +98-711-6261000; E-mail: hoseiniv@sums.ac.ir instillation of scolicidal agents into the cyst cavity t o sterilize the cyst and prevent spreading of the cyst (Balik et al, 1999). Several scolicidal agents were introduced by different researchers including savlon, hypertonic saline, silver nitrate, formaldehyde, ethylalcohol, mebendazole, albendazole and povidone iodine (Houry et al, 1990;Castellano et al, 1994;Erzurumlu et al, 1995;Storanov et al, 1995;Hosseini et al, 2005). One of the most serious late complications occurred after evacuation of the cyst and instillation of various scolocidal agents is sclerosing cholangitis (SC) (Houry et al, 1990;Hosseini et al, 2005).…”