Instillation of Hypertonic Glucose into Gall Bladder of Rabbit: Does it Induce Sclerosing Cholangitis?

Hosseini, Seyed Vahid; Motazedian, G. R.; Mehrabani, Davood; Kumar, Perikala V.; Bagheri, Mohammad Hadi; Tanideh, Nader; Yarmohammadi, Hirad; Sadjadi, S. M.

doi:10.1080/09712119.2006.9706575

Cited by 5 publications

(2 citation statements)

References 9 publications

(10 reference statements)

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“…Although glucose and normal saline solutions in the peritoneal cavity produced, to some extent, nonspecific inflammation but fibrosis or necrosis in the mesentery and parietal peritoneum was not seen and the degree of inflammation caused by 10% and 25% glucose and normal saline was equal [ 17 ]. In addition, Hosseini et al in similar experiments following injection of 10%, 15%, 25%, and 50% glucose concentrations into the gallbladder of rabbits showed that hypertonic glucose is a harmless substance and does not lead to the fibrosis of bile ducts and hepatic necrosis [ 18 ]. Therefore, it is suggested that hypertonic glucose could be a suitable replacement for lots of protoscolicidal materials with side effects.…”

Section: Discussionmentioning

confidence: 99%

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Shahnazi

Badakhsh

Azadmehr

et al. 2014

International Scholarly Research Notices

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Surgical operation is the treatment of choice for hydatid cyst. To date, many protoscolicidal substances have been used for inactivation of hydatid cyst contents but most of these compounds may produce several side effects. The aim of this study was to evaluate the protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst at different concentrations and exposure times. Protoscolices were obtained aseptically from the livers of slaughtered sheep at Qazvin abattoir, Iran. Protoscolices were exposed to different concentrations of hypertonic glucose (10%, 15%, 20%, 25%, 30%, 40%, and 50%) at different times (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, and 60 min). Viability of protoscolices was evaluated by 0.1% eosin and the movement of protoscolices flame cells. The highest protoscolicidal effect (100%) of hypertonic glucose was obtained at concentrations 40% and 50% following 40 and 20 min exposure times, respectively. Some protoscolicidal agents show a variety of dangerous complications such as biliary tract fibrosis and liver necrosis; however, hypertonic glucose especially at a concentration of 40% may demonstrate less side effects compared with glucose 50%. Further in vivo investigations are suggested.

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Section: Discussionmentioning

confidence: 99%

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Shahnazi

Badakhsh

Azadmehr

et al. 2014

International Scholarly Research Notices

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“…Impaired metabolism of cholesterol, bilirubin and bile acids are causative factors for the formation of stones in the hepatic bile duct, common bile duct, or gallbladder. [ 1 2 ] Sedentary lifestyle, female gender, increasing age, ethnicity/family history, obesity, low-density lipoprotein levels, metabolic syndrome, rapid weight loss, certain diseases such as cirrhosis, Crohn disease, and gallbladder stasis were reported as risk factors for gallstones. [ 3 4 ] Regarding concomitant prevalence of gallstone and common bile duct stone (CBDS), old age,[ 5 ] Asian race,[ 6 ] chronic bile duct inflammation,[ 7 ] and hypothyroidism[ 8 ] were shown as risk factors of the disease.…”

Section: Introductionmentioning

confidence: 99%

A survey on concomitant common bile duct stone and symptomatic gallstone and clinical values in Shiraz, Southern Iran

et al. 2016

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Background:Common bile duct stone (CBDS) as a result of gallstone is one of the gastrointestinal disorders. In this study, the incidence of CBDS and symptomatic gallstone in Shiraz were investigated, and their management suggested.Materials and Methods:This is a retrospective study that enrolled among 560 patients. The incidence of gallstone together with CBDS was evaluated using an ultrasonography studyand clinical data in the period between March 2014 and 2014 in Shiraz. Comparison between data was done using Student’s t-test or Chi-square test.Results:Of these patients, 18.6% were male, and 81.4% were female with a mean age of 47.67 ± 0.74 years. The concomitant rate of gallstone and CBDS was 8.6%. 6.8% of patients with concomitant of gallstone and CBDS showed symptoms while 1.8% had not been diagnosed before the operation. The mean of serum alkaline phosphatase level in patients with the only gallstone was 255.80 IU/L and patients with concomitant gallstone, and CBDS was 580.88 IU/L with a significant difference between two groups (P < 0.001). Furthermore, liver function tests (aspartate aminotransferase, alanine transaminase) showed a significant difference between two groups of patients (P < 0.01, P < 0.001).Conclusions:Clinical variables such as tenderness, fever, and Morphy sign were more severein patients with concomitant gallstone and CBDS. The concomitant rate of gallstone and CBDS in our society is less that Western countries and asymptomatic patients showed fewer ratios than other countries. We think the approach for asymptomatic CBDS patients with gallstone can be affected by our results.

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Povidone iodine versus silver nitrate in induction of sclerosing cholangitis in hepatic hydatid cysts surgery

Hosseini

Hassan

Alhurry³

et al. 2017

Comp Clin Pathol

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Instillation of Hypertonic Glucose into Gall Bladder of Rabbit: Does it Induce Sclerosing Cholangitis?

Abstract: Hosseini, S.V., Motazedian, G.R., Mehrabani, D., Kumar, P.V., Bagheri, M.H., Tanideh, N., Yarmohammadi, H. and Sadjadi, S.M. 2006

Cited by 5 publications

References 9 publications

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

A survey on concomitant common bile duct stone and symptomatic gallstone and clinical values in Shiraz, Southern Iran

Povidone iodine versus silver nitrate in induction of sclerosing cholangitis in hepatic hydatid cysts surgery

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