The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction

Abstract

Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium chloride in isolated guinea pig ileum. St was also studied in response to hind paw edema induced by histamine in rats. Experiments revealed that although St (250, 500, and 1,000 g/mL) reduced the histamine-induced contractions by 9.1 ± 1.8, 50.2 ± 2.0, and 68.9 ± 2.0%, respectively, it did not inhibit contractions induced by carbachol or KCl. The association of St (250 and 500 g/mL) with hydroxyzine, an H 1 -antihistamine (0.125 and 0.250 M), increased the inhibitory effect to 67.0 ± 3.2 and 85.1 ± 2.1%, respectively. Moreover, St (100, 200, and 400 mg/kg) decreased paw edema from its peak by 33.9, 48.4, and 54.8%, respectively, whereas hydroxyzine (70 mg/kg) inhibited the peak edema by 56.5%. Altogether, the results suggest that the bark extract of S. terebinthifolius has an antihistaminic effect (H 1 ).

Microbiological quality, chemical profile as well as antioxidant and antidiabetic activities of Schinus terebinthifolius Raddi

“…In traditional medicine, this plant is used to treat skin wounds and ulcers, tumors, diarrhea, arthritis as well as urinary and respiratory tract infections (Brandão et al, 2006). Various pharmacological activities have been described for this plant, including antimicrobial (Silva et al, 2017a), antiulcerogenic (Carlini et al, 2010), anticancer (Silva et al, 2017b), antihistamine (Nunes-Neto et al, 2017), antihypertensive (Glória et al, 2017), antihyperalgesic (Piccinelli et al, 2015), wound healing (Estevão et al, 2017), anti-inflammatory (Silva et al, 2017b) and antioxidant (Rocha et al, 2017) activities in different models.…”

Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection

“…Schinus terebinthifolia Raddi, popularly known as "aroeira," is used in folk medicine for its antimicrobial, antiinflammatory, antiulcerogenic, febrifuge, analgesic, and depurative effects and to treat illnesses of the urogenital system and mucosal lesions (Cavalher-Machado et al, 2008;Lorenzi, Matos, 2008;Soares et al, 2007;Guerra et al, 2000). Antihistaminic (Nunes-Neto et al, 2017) and antihypertensive (Glória et al, 2017) activities have also been attributed to S. terebinthifolia in recent studies.…”