The effect of N⁶‐phenylisopropyladenosine on the regulation of fat cell hexose transport, glucose oxidation and fatty acid release by insulin and catecholamines

Abstract

I@-Phenylisopropyladenosine was employed in the absence of endogenous adenosine to explore the influence exerted by the R-site over the antagonistic interaction of insulin and catecholamines on several parameters of fat cell metabolism. When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulinstimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where I@-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions. N6-phenylisopropyladenosine Fat cell metabolism