Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes

Fabregat, Isabel; Revilla, Elisa; Machado, Alberto

doi:10.1016/0006-291x(87)90618-8

Cited by 49 publications

(27 citation statements)

References 27 publications

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“…Recently, it was reported in a cross-sectional study that serum uric acid levels were associated with visceral fat accumulation (33). Compared with previous studies, the follow-ing features are unique to the present study; 1) inclusion of a large number (1,520 (34,35), and that hyperinsulinemia associated with visceral fat obesity may reduce urinary urate excretion in parallel with a decrease in urinary sodium excretion (36). Recently, several studies reported that hyperuricemia is an independent risk factor for atherosclerotic cardiovascular diseases (37,38), and experimental studies demonstrated that uric acid per se could cause dysfunction of vascular endothelial cells, proliferation of smooth muscle cells and stimulation of production of C-reactive protein from these cells (39,40 …”

Section: T a B L E 3 S T E P Wi S E Mu L T I P L E Re G R E S S I Omentioning

confidence: 84%

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

et al. 2008

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Section: T a B L E 3 S T E P Wi S E Mu L T I P L E Re G R E S S I Omentioning

confidence: 84%

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

et al. 2008

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“…Visceral fat accumulation (VFA) induces an elevated influx of plasma free fatty acids into the hepatic portal vein and liver. This stimulates triglycerides synthesis followed by an attendant surge in UA production through the activated UA synthesis pathway [38,39]. In addition, a number of investigators have reported that VFA is significantly associated with BMI [40,41].…”

Section: Discussionmentioning

confidence: 99%

The relationship between body mass index and uric acid: a study on Japanese adult twins

Tanaka

Ogata

Tanaka

et al. 2015

Environ Health Prev Med

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Objectives The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors. Methods The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed. Results In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0. Conclusions The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.

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“…Moguće objašnjenje za ovakav nalaz je povećana akumulacija masti u visceralnom masnom tkivu, povećan dotok slobodnih masnih kiselina putem portalne vene do jetre i povećanje sinteze lipoproteina veoma niske gustine, sa posledičnom hipertrigliceridemijom. To, takođe, ubrzava de novo sintezu NADPH u pentozofosfatnom putu što rezultira povećanom sintezom MK [16]. Naše istraživanje ne pronalazi korelaciju sMK sa lipidnim parametrima.…”

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Influence of obesity on serum uric acid level in postmenopausal women

Klisić¹,

Kotur‐Stevuljević²,

Kavarić³

et al. 2016

Tim Med Glas

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(1) DOM ZDRAVLJA, PODGORICA, CRNA GORA, (2) FARMACEUTSKI FAKULTET, UNIVERZITET U BEOGRADU, SRBIJA Sažetak :Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol -vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p<0,001), zatim cistatin C (Beta=0,300; p<0,001), (R2=0,467; p<0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti. Ključne riječi: inflamacija, gojaznost, menopauza, mokraćna kiselina. Summary:Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p<0.001), and cystatin C (Beta=0.300, p<0.001)...

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Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes

Cited by 49 publications

References 27 publications

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

The relationship between body mass index and uric acid: a study on Japanese adult twins

Influence of obesity on serum uric acid level in postmenopausal women

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