Influence of obesity on serum uric acid level in postmenopausal women

Klisić, Aleksandra; Kotur‐Stevuljević, Jelena; Kavarić, Nebojša; Jovanović, Milovan

doi:10.5937/tmg1601020k

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…In addition to this, we previously reported a significant relationship between serum uric acid level and anthropometric parameters, stronger with WC than with BMI, implicating that visceral adipose tissue is the main determinant of serum uric acid level [26]. Furthermore, in our previous study we showed that uric acid correlated with the majority of components of MetS, including insulin resistance.…”

Section: Discussionsupporting

confidence: 68%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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Summary:Aim: The data regarding the prevalence of metabolic syndrome (MetS) among postmenopausal women in Montenegro is limited. Therefore, the aim of this study was to evaluate this prevalence and to examine its association with serum uric acid level, an established cardiometabolic risk factor. Methods: A total of 242 postmenopausal women (aging 43-68) were included. Fasting glucose, lipid parameters, and uric acid were determined with the standard procedure. Blood pressure and anthropometric parameters were obtained. MetS was diagnosed according to the modified US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: The prevalence of MetS in postmenopausal women was 42.1%. The most prevalent component was abdominal obesity (65.3%), following by hypertension (systolic blood pressure and diastolic blood pressure accounting for 54.1% and 49.2% respectively), hyperglycemia (40.5%), and dyslipidemia (high triglycerides and low HDL-c level accounting for 30.2% and 25.2% respectively). Uric acid levels were significantly higher in postmenopausal women with MetS than in those without MetS (P<0.001). Moreover, a significantly higher number of patients with MetS as compared to subjects without diagnosed MetS across uric acid tertiles was found (χ2=27.02, P<0.001). Conclusion: MetS is highly prevalent among postmenopausal women in Montenegro and correlated with higher uric acid level. Abdominal obesity is the most prevalent feature of the syndrome. This suggests the importance of reducing obesity and lowering uric acid level in prevention of cardiometabolic diseases. Keywords:abdominal obesity, metabolic syndrome, postmenopausal, uric acid Sažetak:Cilj: Nema podataka o prevalenci metaboličkog sindroma (MetS) kod žena u periodu postmenopauze u Crnoj Gori. Stoga je cilj studije bio da se utvrdi ova prevalenca i ispita povezanost MetSa sa mokraćnom kiselinom u serumu, poznatim kardiometaboličkim faktorom rizika. Metode: U studiju su uključene 242 žene u postmenopauzi (starosti 43-68 godina). Glikemija našte, lipidni status i mokraćna kiselina su određivani standardnom procedurom. Mereni su i krvni pritisak i antropometrijski parametri. MetS je dijagnostikovan prema modifikovanim smernicama Američkog nacionalnog programa za edukaciju o holesterolu -Preporuke panela III za lečenje odraslih. Rezultati: Prevalenca MetS-a kod žena u postmenopauzi je iznosila 42,1%. Najučestalija komponenta je bila abdominalna gojaznost (65,3%), potom hipertenzija (sistolna -54,1% i dijastolna -49,2%), hiperglikemija (40,5%), dislipidemija (hipertrigliceridemija -30,2%) i niske vrednosti lipoproteina velike gustine (HDL-holesterol -25,2%). Srednje vrednosti serumske mokraćne kiseline bile su značajno više kod žena sa MetS-om u poređenju sa kontrolnom grupom (P<0,001). Takođe, značajno veći broj ispitanica sa MetS-om je zabeležen u tercilnoj grupi sa najvišom koncentracijom mokraćne kiseline u serumu (χ 2 =27,02; P<0,001). Zaključak: Zabeležena je visoka prevalenca MetS-a kod žena u postmenopauzi u Crnoj Gori, kao ...

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Section: Discussionsupporting

confidence: 68%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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“…(19) pokazala da i predgojazna/gojazna deca uzrasta 6-24 meseca imaju više vrednosti leptina i kortizola, a niže aktivnosti CAT i SOD u poređenju sa kontrolnom grupom. Mnoge studije opisuju izmenjenu antioksidativnu zaštitu kod gojaznih osoba (20,21,22,23). Niža koncentracija bilirubina, koji ispoljava antioksidativno i antiinflamatorno dejstvo, je zabeležena kod gojaznih adolescentkinja.…”

Section: Masno Tkivo Kao Značajan Izvor Slobodnih Radikalaunclassified

Oksidativni Stres Kod Gojazne Dece-Kako Ga Sprečiti Ili Smanjiti?

Klisić,

Kavarić

2018

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Hipertofično masno tkivo je značajan izvor reaktivnih vrsta kiseonika (RVK) koji dovode do povećanja ekspresije adipokina i infiltracije inflamatornih ćelija. Ovi poslednji dalje sekretuju nove RVK čineći tako povratnu spregu između oksidativnog stresa i inflamacije u masnom tkivu, sa posledičnim promenama u signalnim putevima i brojnim poremećajima kao što su metabolički sindrom, diabetes mellitus tip 2, kardiovaskularne bolesti. Istraživanja pokazuju da promena životnih navika zasnovana na promeni načina ishrane, kao i povećana i redovna fizička aktivnost mogu dovesti do smanjenja oksidativnog stresa i inflamacije. Takođe, skorije studije pokazuju da suplementacija antioksidansima može popraviti antioksidantni status. U daljim redovima će biti reči o patofiziološkim mehanizmima gojaznošću indukovanog oksidativnog stresa kod dece i adolescenata, kao i strategiji u cilju smanjenja istog.

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“…The current cross-sectional study derived from our previous works investigating the utility of examining cardiometabolic markers in postmenopausal women [1][2][3][4][5][6][7]. A total of 150 postmenopausal women nontreated with medications (among them 44.7% hypertensive) were included in cross-sectional study.…”

Section: Study Populationmentioning

confidence: 99%

“…It is speculated that redistribution of adipose tissue towards visceral region, due to hormonal changes may be the main pathogenic entity, consequently leading to increased cardiometabolic risk [4] in postmenopause. Increased visceral fat mass is a source of proinflammatory adipocytokines [5][6][7][8], exerting a low-grade inflammation environment which could predispose to the future hypertension occurrence [9]. In addition, increased abdominal fat mass is accompanied with increased insulin resistance [4,8].…”

Section: Introductionmentioning

confidence: 99%

Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

Klisić¹,

Stanišić²,

Jovanović³

et al. 2017

Tim Med Glas

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Sažetak:Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Ključne reči: hipertenzija, insulinska rezistencija, gojaznost, žene u postmenopauzi Abstract:Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women.

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Influence of obesity on serum uric acid level in postmenopausal women

Cited by 4 publications

References 13 publications

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Oksidativni Stres Kod Gojazne Dece-Kako Ga Sprečiti Ili Smanjiti?

Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

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