Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović, Milovan; Klisić, Aleksandra; Kavarić, Nebojša; Skerovic, Verica

doi:10.5937/tmg1603196j

Cited by 2 publications

(4 citation statements)

References 21 publications

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“…The current cross-sectional study derived from our previous works investigating the utility of examining cardiometabolic markers in postmenopausal women [1][2][3][4][5][6][7]. A total of 150 postmenopausal women nontreated with medications (among them 44.7% hypertensive) were included in cross-sectional study.…”

Section: Study Populationmentioning

confidence: 99%

“…It is well known that women experiencing menopause have unfavorable cardiometabolic profile, compared to women in reproductive age [1]. These changes are mostly attributable to hormonal disturbances, mainly due to loss of estrogen [2].…”

Section: Introductionmentioning

confidence: 99%

“…These changes are mostly attributable to hormonal disturbances, mainly due to loss of estrogen [2]. Therefore, it is not surprising that postmenopausal women had higher incidence of cardiometabolic disorders than premenopausal women [1,3]. It is speculated that redistribution of adipose tissue towards visceral region, due to hormonal changes may be the main pathogenic entity, consequently leading to increased cardiometabolic risk [4] in postmenopause.…”

Section: Introductionmentioning

confidence: 99%

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Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

Klisić¹,

Stanišić²,

Jovanović³

et al. 2017

Tim Med Glas

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Sažetak:Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Ključne reči: hipertenzija, insulinska rezistencija, gojaznost, žene u postmenopauzi Abstract:Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women.

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Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

Klisić¹,

Stanišić²,

Jovanović³

et al. 2017

Tim Med Glas

Self Cite

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“…Women at reproductive age are at a lower risk of obesity-related comorbidities, compared with postmenopausal women [1]. However, a plethora of metabolic disturbances accompanied with an increased visceral obesity, such as dyslipidemia, insulin resistance, hypertension are observed in women after menopause [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels

Klisić¹,

Stanišić²,

Jovanović³

et al. 2017

Timočki medicinski glasnik

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BEOGRADU-FARMACEUTSKI FAKULTET, SRBIJA Sažetak: Cilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p<0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja. Ključne reči: adipokini, insulinska rezistencija, gojaznost, postmenopauza, retinol-vezujući protein 4

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Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Cited by 2 publications

References 21 publications

Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women

Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels

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