Adenosine enhances myocardial glucose uptake only in the presence of insulin

Law, William R.; McLane, Michael

doi:10.1016/0026-0495(91)90071-4

Cited by 21 publications

(11 citation statements)

References 18 publications

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“…Animal studies have shown that, although intact adenosine‐receptors are needed for insulin to increase myocardial glucose uptake (Law et al . ), adenosine also increases myocardial glucose uptake only in the presence of insulin (Law & McLane, ). This also provides an interesting perspective for our findings of significant positive association between insulin‐stimulated glucose uptake and hyperaemic perfusion in the myocardium.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Eskelinen

Heinonen

Löyttyniemi

et al. 2016

The Journal of Physiology

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High-intensity interval training (HIIT) is a time-efficient way of obtaining the health benefits of exercise, although the cardiac effects of this training mode are incompletely known. We compared the effects of short-term HIIT and moderate intensity continuous training (MICT) interventions on myocardial perfusion and metabolism and cardiac function in healthy, sedentary, middle-aged men. Twenty-eight healthy, middle-aged men were randomized to either HIIT or MICT groups (n = 14 in both) and underwent six cycle ergometer training sessions within 2 weeks (HIIT session: 4-6 × 30 s all-out cycling/4 min recovery, MICT session 40-60 min at 60% V̇O2 peak ). Cardiac magnetic resonance imaging (CMRI) was performed to measure cardiac structure and function and positron emission tomography was used to measure myocardial perfusion at baseline and during adenosine stimulation, insulin-stimulated glucose uptake (MGU) and fasting free fatty acid uptake (MFFAU). End-diastolic and end-systolic volumes increased and ejection fraction slightly decreased with both training modes, although no other changes in CMRI were observed. MFFAU and basal myocardial perfusion remained unchanged. MGU was decreased by training (HIIT from 46.5 to 35.9; MICT from 47.4 to 44.4 mmol 100 g min , P = 0.007 for time, P = 0.11 for group × time). Adenosine-stimulated myocardial perfusion responded differently to the training modes (change in mean HIIT: -19%; MICT: +9%; P = 0.03 for group × time interaction). HIIT and MICT induce similar metabolic and functional changes in the heart, although myocardial vascular hyperaemic reactivity is impaired after HIIT. This should be taken into account when prescribing very intense HIIT for previously untrained subjects.

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Section: Discussionmentioning

confidence: 99%

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Eskelinen

Heinonen

Löyttyniemi

et al. 2016

The Journal of Physiology

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“…Observations regarding effects of adenosine on glucose metabolism have been conflicting, and responses in humans are yet to be assessed. A number of studies support adenosine and AR stimulation of myocardial glucose uptake (123)(124)(125)(126)(127), a response that may reflect potentiation of insulin's actions (128)(129)(130). Indeed, some work indicates that the effects of insulin require functional AR activity (130).…”

Section: Regulation Of Myocardial Substrate Metabolismmentioning

confidence: 99%

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation

Headrick

Peart

Reichelt

et al. 2011

Biochimica et Biophysica Acta (BBA) - Biomembranes

122

108

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The purine nucleoside adenosine is an important regulator within the cardiovascular system, and throughout the body. Released in response to perturbations in energy state, among other stimuli, local adenosine interacts with 4 adenosine receptor sub-types on constituent cardiac and vascular cells: A(1), A(2A), A(2B), and A(3)ARs. These G-protein coupled receptors mediate varied responses, from modulation of coronary flow, heart rate and contraction, to cardioprotection, inflammatory regulation, and control of cell growth and tissue remodeling. Research also unveils an increasingly complex interplay between members of the adenosine receptor family, and with other receptor groups. Given generally favorable effects of adenosine receptor activity (e.g. improving the balance between myocardial energy utilization and supply, limiting injury and adverse remodeling, suppressing inflammation), the adenosine receptor system is an attractive target for therapeutic manipulation. Cardiovascular adenosine receptor-based therapies are already in place, and trials of new treatments underway. Although the complex interplay between adenosine receptors and other receptors, and their wide distribution and functions, pose challenges to implementation of site/target specific cardiovascular therapy, the potential of adenosinergic pharmacotherapy can be more fully realized with greater understanding of the roles of adenosine receptors under physiological and pathological conditions. This review addresses some of the major known and proposed actions of adenosine and adenosine receptors in the heart and vessels, focusing on the ability of the adenosine receptor system to regulate cell function, retaliate against injurious stressors, and mediate longer-term adaptive responses.

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“…Exercise and muscle contraction also promote glucose uptake by stimulating GLUT4 translocation, but rely on activation of non-PI3K/Akt pathways (Rose and Richter 2005). In both adipocytes (Joost et al 1986;Kuroda et al 1987) and the heart (Law and McLane 1991), adenosine has consistently been shown to potentiate insulin-stimulated glucose uptake. In adipose tissue, adenosine is also a potent antilipolytic agent (Heseltine et al 1995;van Schaick et al 1998).…”

Section: Introductionmentioning

confidence: 96%

Activation of the A₁adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle

Thong

Lally

Dyck

et al. 2007

Appl. Physiol. Nutr. Metab.

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The A1 adenosine receptor (A1AR) has been suggested to participate in insulin- and contraction-stimulated glucose transport in skeletal muscle, but the qualitative and quantitative nature of the effect are controversial. We sought to determine if A1AR is expressed in rat soleus muscle and then characterize its role in glucose transport in this muscle. A1AR mRNA and protein expression were determined by RT-PCR and Western blotting, respectively. To examine the role of adenosine in 3-O-methylglucose transport, isolated muscles were exposed to adenosine deaminase and alpha,beta-methylene adenosine diphosphate to remove endogenous adenosine and were left unstimulated (basal) or stimulated with insulin. To assess the functional participation of A1AR in 3-O-methylglucose transport, muscles were incubated with A1-selective agonist and (or) antagonist in the absence of endogenous adenosine and with or without insulin. A1AR mRNA was expressed in soleus muscle and A1AR was present at the plasma membrane. Removal of endogenous adenosine reduced glucose transport in response to 100 microU/mL insulin (approximately 50%). The A1-selective agonist, N6-cyclopentyladenosine, increased submaximal (100 microU/mL) insulin-stimulated glucose transport in a dose-dependent manner (0.001-1.0 micromol/L). This stimulatory effect was inhibited by the A1-selective receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine in a concentration-dependent manner (0.001-1.0 micromol/L). However, neither activation nor inhibition of A1AR altered basal or maximal (10 mU/mL) insulin-stimulated glucose transport. Our results suggest that adenosine contributes approximately 50% to insulin-stimulated muscle glucose transport by activating the A1AR. This effect is limited to increasing insulin sensitivity, but not to either basal or maximal insulin-stimulated glucose uptake in rat soleus muscle.

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Adenosine enhances myocardial glucose uptake only in the presence of insulin

Cited by 21 publications

References 18 publications

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation

Activation of the A₁adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle

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Adenosine enhances myocardial glucose uptake only in the presence of insulin

Cited by 21 publications

References 18 publications

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Left ventricular vascular and metabolic adaptations to high‐intensity interval and moderate intensity continuous training: a randomized trial in healthy middle‐aged men

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation

Activation of the A1adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle

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Activation of the A₁adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle