The Effect of <i>Hypericum perforatum</i> on the Wound Healing and Scar of Cesarean

Samadi, Sareh; Khadivzadeh, Talat; Emami, Seyed Ahmad; Moosavi, Naser Sanjar; Tafaghodi, Mohsen; Behnam, Hamid Reza

doi:10.1089/acm.2009.0317

Cited by 86 publications

(69 citation statements)

References 22 publications

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“…So we can say that early usage of centaury oil (first 7 days of wound) had positive effect on wound healing. So, we obtained similar results due to literature findings (5). In group B, only granulation tissue, scar uncertainty and refeathering properties were a little different from control group.…”

Section: Cmjsupporting

confidence: 89%

Molecular view to the effect of centaury oil on wound healing

Çoban¹,

Yener²,

Benli³

et al. 2016

Cumhuriyet Med J

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SUMMARYObjective: Centaury oil (the extract of Hypericum perforatum obtained with olive oil) is traditionally used for the treatment of wounds in Turkey. Centaury oil has analgesic and antiinfectious properties beside wound healing effect. There are many studies about the positive effect of this extract on wound healing in literature. But there is no mention about the animal studies that show which pathways are involved in. Method: In our study the effect of centaury oil in early stages (first 7 days) and late stages (second 7 days) of wound healing was showed on the mice (mus. musculus) by creating sterile sutures on their back. In addition, the gene expression profiles of VEGFA, VEGFB, VEGFC, PDGFB and FGF2 genes which have roles in wound healing via angiogenesis were studied by RT-PCR method. Results: Due to our results, centaury oil has positive effects on the surface of the wounds in early stages but has no effect on late stages. The gene expression levels of VEGFA, VEGFB, VEGFC and FGF2 were increased in early stages of wound healing but only VEGFA gene expression level was increased in late stages. The gene expression findings were correlated with morphological findings in both early and late stages of wound healing. Conclusions: According to our morphological results, centaury oil can be useful if it is used in the first week of the wound. At the end of our study, our findings are important for exploring the effect of centaury oil on angiogenesis via VEGFA, VEGFB, VEGFC and FGF2 genes in early stages of wound healing. Keywords: Centaury oil, Hypericum perforatum L., wound healing, angiogenesis, gene. ÖZET Amaç: Kantaron yağı (Hypericum perforatum' un zeytinyağı ile elde edilen ekstresi) Türkiye' de yıllardır çeşitli yaraların tedavisinde geleneksel olarak kullanılmaktadır. Kantaron yağının yara iyileştirici özellikleri yanında anti-enflamatuar ve anti-inflamatuar özellikleri bulunmaktadır. Literatürde bu yağın yara iyileşmesine olan pozitif etkisi ile ilgili birçok çalışma vardır. Ancak literatürde şimdiye dek bu özelliklerin hangi yolaklar üzerinden olduğunu gösterir hayvan deneylerini içeren detaylı bir çalışma bulunmamaktadır. Yöntem: Çalışmamızda kantaron yağının yara iyileşmesi üzerine erken dönem (ilk 7 gün) ve geç dönem (ikinci 7 gün) etkisi; farelerde (mus. musculus) sırt bölgesinde steril sütürler oluşturulup farklı zaman aralıklarında kantaron yağı uygulanarak gösterilmeye çalışılmıştır. Çalışmamızda ayrıca bu dönemde tüm gruplardan alınan dokulardan Real Time PCR yöntemi ile anjiyogenez üzerinden yara iyileşmesinde aktif rol oynayan VEGFA, VEGFB, VEGFC, PDGFB ve FGF2 132 CMJCumhuriyet Medical Journal genlerinin gen ekspresyon profilleri incelenmiştir. Bulgular: Elde ettiğimiz sonuçlara göre, farelerde oluşturulan yara yüzeylerinde morfolojik olarak kantaron yağının erken dönem kullanımında yara iyileşmesine pozitif etkisi olmakta, geç dönem uygulanmasında ise yara iyileştirici etkisi görülmemektedir. Yara iyileşmesinin erken dönemlerinde (akut dönem) VEGFA, VEGFB, VEGFC ve FGF2 genlerinin gen ...

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Section: Cmjsupporting

confidence: 89%

Molecular view to the effect of centaury oil on wound healing

Çoban¹,

Yener²,

Benli³

et al. 2016

Cumhuriyet Med J

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“…Even though a number of studies have been conducted to understand the mechanism of HP treatment on various disease conditions (Albert et al, 2002;Tedeschi et al, 2003;De Paola et al, 2005;Genovese et al, 2006a,b;Hammer et al, 2007;Saad et al, 2008;Dost et al, 2009;Cirak et al, 2010;Kraus et al, 2010;Samadi et al, 2010) only a few of them have reported the effect of HP on contractility of vascular system (Melzer et al, 1991;Apaydin et al, 2001;Gilani et al, 2005;Khan et al, 2009Khan et al, , 2010, however, there are no scientific reports with HP detailing its modulatory effects on the vascular tone. Hence, this study has investigated the vascular effects of HP at both smooth muscle and endothelial level.…”

Section: Discussionmentioning

confidence: 99%

“…Hypericum species is increasing as a new self-medication approach for many diseases such as depression (Apaydin et al, 2001;Mennini & Gobbi, 2004;Pilkington et al, 2006) wound healing (Cirak et al, 2010;Samadi et al, 2010), anti-inflammatory (Mukerjee et al, 2008;Hammer et al, 2010) and antiviral (Mukerjee et al, 2008). Additionally, our previous study shows the protective effect of Hypericum perforatum (HP) on trinitrobenzene sulfonic acid-induced inflammatory bowel disease (Dost et al, 2009).…”

Section: The Popularity Of Traditional Herbal Therapy Withmentioning

confidence: 99%

The effect ofHypericum perforatumon isolated rat aorta

Tugrul

Demirci

Demir

et al. 2011

Pharmaceutical Biology

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“…They also reduce the pain and discomfort during its usage as an extract 3,4 . The studies in literature about the centaury oil, there were many morphological evaluations on wound healing but there was no study about the effect mechanisms and the effected genes 5,6 . In the first part of our study, we aimed to find out the effects of centaury oil on wound healing.…”

Section: Introductionmentioning

confidence: 99%

KANTARON YAĞI VEGFA, VEGFB, VEGFC ve FGF2 GENLERİ ÜZERİNDEN ERKEN DÖNEM KULLANILDIĞINDA YARA İYİLEŞMESİNDE OLUMLU ETKİ GÖSTERMEKTEDİR

Çoban¹,

Yener²,

Benli³

et al. 2016

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

SUMMARYCentaury oil (the extract of Hypericum perforatum obtained with olive oil) is traditionally used for the treatment of wounds in Turkey. Centaury oil has analgesic and anti-infectious properties beside wound healing effect. There are many studies about the positive effect of this extract on wound healing in literature. But there is no mention about the animal studies that show which pathways are involved in. In our study the effect of centaury oil in early stages (first 7 days) and late stages (second 7 days) of wound healing was showed on the mice (mus. musculus) by creating sterile sutures on their back. Due to our results, centaury oil has positive effects on the surface of the wounds in early stages but has no effect on late stages. This information is explained as centaury oil can be useful if it is used in the first week of the wound. In addition, the gene expression profiles of VEGFA, VEGFB, VEGFC, PDGFB and FGF2 genes which have roles in wound healing via angiogenesis, were studied by RT-PCR method. As a result, the gene expression levels of VEGFA, VEGFB, VEGFC and FGF2 were increased in early stages of wound healing but only VEGFA gene expression level was increased in late stages. The gene expression findings were correlated with morphological findings in both early and late stages of wound healing. Our findings are important for exploring the effect of centaury oil on angiogenesis via VEGFA, VEGFB, VEGFC and FGF2 genes in early stages of wound healing. Keywords : Centaury oil, Hypericum perforatum L., wound healing, angiogenesis, gene ÖZET Kantaron yağı (Hypericum perforatum' un zeytinyağı ile elde edilen ekstresi) Türkiye' de yıllardır yara tedavisinde geleneksel olarak kullanılmaktadır. Kantaron yağının yara iyileştirici özellikleri yanında ağrı kesici, enfeksiyon engelleyici özellikleri bulunmaktadır. Literatürde bu yağın yara iyileşmesine olan pozitif etkisi ile ilgili birçok çalışma vardır. Ancak literatürde şimdiye dek bu özelliklerin hangi yolaklar üzerinden olduğunu gösterir hayvan deneylerini içeren detaylı bir çalışma bulunmamaktadır. Çalışmamızda kantaron yağının yara iyileşmesi üzerine erken dönem (ilk 7 gün) ve geç dönem (ikinci 7 gün) etkisi farelerde (mus. musculus) sırt bölgesinde steril sütürler oluşturularak gösterilmiştir. Sonuçlarımıza göre, farelerde oluşturulan yara yüzeyinde morfolojik olarak kantaron yağının erken dönem kullanımda pozitif etkisi olmakta, geç dönem uygulamada bu etki görülmemektedir. Bu bulgu kantaron yağının yara iyileşmesine yara oluştuktan sonraki ilk haftada pozitif etkisi olduğu şeklinde yorumlanmıştır. Bu dönemde alınan dokulardan RT-PCR yöntemi ile anjiyogenez üzerinden yara iyileşmesinde rolü olan VEGFA, VEGFB, VEGFC, PDGFB ve FGF2 genlerinin gen ekspresyon profilleri incelenmiştir. Sonuç olarak erken dönemde VEGFA, 232 CMJCumhuriyet Medical Journal VEGFB, VEGFC ve FGF2 genlerinin gen ekspresyonları artmakta, geç dönemde bu etki yalnızca VEGFA geninde saptanmaktadır. Erken ve geç dönemde bulunan gen ekspresyonu bulguları saptanan morfolojik özellik...

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The Effect of Hypericum perforatum on the Wound Healing and Scar of Cesarean

Abstract: Topical application of H. perforatum is safe and can facilitate cesarean wound healing and minimize formation of scar and its pain and pruritus.

Cited by 86 publications

References 22 publications

Molecular view to the effect of centaury oil on wound healing

Molecular view to the effect of centaury oil on wound healing

The effect ofHypericum perforatumon isolated rat aorta

KANTARON YAĞI VEGFA, VEGFB, VEGFC ve FGF2 GENLERİ ÜZERİNDEN ERKEN DÖNEM KULLANILDIĞINDA YARA İYİLEŞMESİNDE OLUMLU ETKİ GÖSTERMEKTEDİR

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