The effect of hyperthermic preconditioning on the immune system in rat peritonitis

Ozveri, ES; Bekraki, A; Cingi, Asım; Yüksel, Meral; Demiralp, EE; Yeğen, Berrak Ç.; Aktan, A. Özdemir

doi:10.1007/s001340051028

Cited by 19 publications

(14 citation statements)

References 17 publications

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“…Moreover, survival analysis could contribute to the understanding of better outcome in this rat peritonitis model. However, in our previous study [7], we had given the necessary data on survival analysis, which were consistent with the improved immune response in HP groups.…”

Section: Original Researchsupporting

confidence: 66%

“…This study was a foregoing study of our group's previous work on HP [7]. In that study, 42 ± C thermal stress was induced as preconditioning 8 h prior to induction of peritonitis and the immune system was improved.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, our recent report [7] indicated that this protection against peritonitis in rats was closely associated with the immune system stimulation. It is most probable that the time interval between the heat exposure and the induction of main stress is the common denominator for the protective role of HP.…”

Section: Original Researchmentioning

confidence: 96%

“…In the Hotchkiss study, the maximum expression of hsps for all organs had occured by 8-12 h. In our study, a duration of 4 h was found to be adequate for the expression of bene cial preconditioning in rat peritonitis. In our previous study [7], a duration of 8 h was used, but this study revealed that a shorter period is possible. The protective role of HP was not obtained when it was applied at the time of the septic insult.…”

Section: Original Researchmentioning

confidence: 97%

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Optimal Timing and Temperature for Hyperthermic Preconditioning in an Animal Model of Fecal Peritonitis

Güllüoğlu

Aksoy

Özveri

et al. 2002

Journal of Investigative Surgery

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The impact of immune parameters in the mechanism of hyperthermia is yet to be explained. In this study, the optimal timing and temperature of thermal treatment for reversing the abnormal immunologic parameters obtained in a rat model of peritonitis were planned to be determined. Male Sprague-Dawley rats were grouped as sham, control peritonitis, and thermally treated rats at the time of peritonitis or 4 h prior to induction of peritonitis both at 40 and 42 degrees C. Peritonitis was induced by the cecal ligation and perforation model. Eight hours after the induction of peritonitis, rats were sacrified and samples were taken for measurements of CD4+, CD8+, CD(11b), B cells, NK cells, and tumor necrosis factor alpha (TNFalpha) and thiobarbituric acid-reactive substances (TBARS) levels. CD4+ expression and B cell amount were decreased whereas TNFalpha levels, CD8+ and CD(11b) expression, and NK cell amount were found to be increased in the control peritonitis group when compared to the sham group. Peritonitis induction also increased TBARS levels in liver tissue. Hyperthermic preconditioning at either 40 or 42 degrees C applied 4 h prior to peritonitis induction returned all parameters to their normal levels, which is similar to the results of the sham laparotomy group. The results of TNFalpha values in preconditioned rats were varied according to the temperature that was applied. The levels were increased at 40 degrees C, whereas they showed a decline at 42 degrees C. Hyperthermic preconditioning prevented the oxidative damage in liver as well as TNFalpha elevation, particularly at 42 degrees C. Results from this study suggest that hyperthermic preconditioning 4 h prior to the onset of septic events may improve the adverse outcome in sepsis.

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Section: Original Researchsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Original Researchmentioning

confidence: 96%

Section: Original Researchmentioning

confidence: 97%

See 2 more Smart Citations

Optimal Timing and Temperature for Hyperthermic Preconditioning in an Animal Model of Fecal Peritonitis

Güllüoğlu

Aksoy

Özveri

et al. 2002

Journal of Investigative Surgery

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“…It has protective effects against the development of infection [34,35] and in many critically ill patients it is generally felt to be more protective than dangerous. Brain-injured patients are an exception, since in them the deleterious effects of pyrexia may exceed the benefits [35].…”

Section: Discussionmentioning

confidence: 99%