Thermotherapy of Pain, Trauma, and Inflammatory and Degenerative Rheumatic Diseases

Schmidt, K.; Simón, E.

doi:10.1007/978-4-431-67035-3_61

Cited by 19 publications

(9 citation statements)

References 48 publications

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“…Hyperthermia can lead to enhancement of tissue perfusion, skeletal muscles relaxation, and tension reduction in soft tissue (Schmidt and Simon, 2001). In recent years, thermotherapy has also been found to have positive effects upon bone formation.…”

Section: Magnetism and Hyperthermiamentioning

confidence: 99%

Magnetic Materials in Promoting Bone Regeneration

et al. 2019

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Strategies to promote bone regeneration have been always the focus of investigations since the skeleton plays important roles like mechanical support, organ protection, and mineral homeostasis maintenance in the normal physiological activities of the human body. Magnetic fields have shown to be highly influential in the regeneration process, arousing tremendous interest in utilizing magnetic materials to enhance osteogenesis. In this work, we attempt a more comprehensive and detailed review of magnetic materials in promoting bone regeneration by including not only the mechanisms of bone regeneration, the history and basic concepts of magnetism, but also the types of magnetic materials as well as their influence parameters, designs and fabrication techniques with a focus on their usage in the field of bone regeneration like 3D printed scaffolds and implants. In addition, we provide some possible ideas on the synergistic action between magnetic and other materials on bone tissue. Finally, we propose the development trend of magnetic materials in the field of bone regeneration in the future. There is a huge demand for a more effective and less traumatic way to accelerate bone regeneration of the patients with diseases like fractures, tumors and osteoporosis that cause severe pains, bone loss, limb deformations, and restrictions of mobility. Magnetic materials have substantial potential to be manufactured into novel clinical applications with the ability to increase the bone regeneration efficiency.

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Section: Magnetism and Hyperthermiamentioning

confidence: 99%

Magnetic Materials in Promoting Bone Regeneration

et al. 2019

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“…That effect is used in oncological hyperthermia, but in the therapy of rheumatic diseases, as opposed to that observed in oncology, it depends on the range of temperatures used and the type of hyperthermia applied (topical or systemic) [ 6 ]. The use of hyperthermia at temperatures exceeding 41°C leads to suppression of the immune system [ 7 ], while so-called mild topical hyperthermia (temperature below 41°C) stimulates the immune system and leads to activation of two proinflammatory cytokines: interleukin 1 and interleukin 6, with a simultaneous decrease of the concentrations of two other cytokines: prostaglandin E2 and leukotriene B4, while so-called intensive topical hyperthermia (temperature above 41°C) leads to suppression of the humoral and cell-mediated immune responses. A similar effect is observed in the case of intensive systemic hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

“…Application of mild whole-body hyperthermia in fibromyalgia resulted in significant reduction of pain immediately after the treatment, and after nine hyperthermia treatments during three weeks pain no longer reached its pre-treatment level [ 7 ]. Local heat application may be of significant benefit in inflammatory and noninflammatory rheumatic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Hyperthermia in rheumatic diseases. A promising approach?

Jeziorski

2018

Reumatologia

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Hyperthermia is a method applied in the treatment of many diseases, including rheumatic diseases. There are relatively few reports concerning the role of that method in the treatment of these diseases, and most studies have not been randomised. Hyperthermia includes directed application of thermal energy. The aim of that therapy is to overcome the body’s natural thermoregulation mechanism through application of external heat sources such as electromagnetic radiation of various frequencies, or ultrasound. Usually, temperatures are used within the 38.5–43° range. Hyperthermia can be applied as topical, regional, or systemic treatment (the latter is called hyperthermia of the whole body). In rheumatology, mainly the effect of hyperthermia on the immune system of the body is used. That effect depends on the type of hyperthermia and temperatures applied. Best documented are the effects of hyperthermia in fibromyalgia and ankylosing spondylitis.

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“…Im Gegensatz zur intensiven bewirkt eine mäûig starke und moderate Hyperthermie (39 ± 41 8C) konträre Wirkungen im Sinne einer Immunstimulation/Immunmodulation [5,6], was auf eine mögliche Vernetzung von Thermoregulations-und Immunsystem hindeutet [7]. Wärme stellt einen somatischen Stressor dar und Kortisol, das den Stresshormonen zugerechnet wird, zeigt einen weitgehend synchronen Anstieg unter akuten Stresssituationen [8].…”

Section: Introductionunclassified

Einfluss der milden Hyperthermie auf die Blutspiegel von Kortisol und Lymphozytensubpopulationen bei Patienten mit ankylosierender Spondylitis und Gesunden

Lange¹,

Thielen²,

Neeck³

et al. 2005

Phys Rehab Kur Med

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Zusammenfassung Fragestellung: Die passive Überwärmung des Körpers (Hyperthermiebehandlung) bewirkt bei der ankylosierenden Spondylitis (AS) ohne akute Entzündungsaktivität überzufällig häufig günstige Einflüsse auf das Beschwerdebild. Die Ursachen dieses Effektes sind nach wie vor unklar. Methodik: Untersucht wurde die Frage einer ¹Stressreaktionª des Organismus bei 24 Personen (12 Patienten und 12 Gesunde gleicher Altersstruktur) durch ein Überwärmungsbad (bis zum Erreichen einer Körpertemperatur von 38,5 8C s. l.; Dauer des Bades 50 Minuten). Es erfolgte zu Beginn des Bades sowie alle 30 Minuten nach Beendigung des Bades über einen Zeitraum von 4 Stunden eine Bestimmung des Kortisols, der Gesamtlymphozyten einschlieûlich deren Subpopulationen (B-, T-, CD4-, CD8-Zellen). Ergebnisse: Es konnte im Beobachtungszeitraum keine signifikante ¾nderung des Kortisols, der Gesamtlymphozyten und deren Subpopulationen objektiviert werden, zudem zeigten sich keine signifikanten Unterschiede zwischen den Werten in der Patienten-und Kontrollgruppe. Schlussfolgerung: Der durch systemische milde Hyperthermie hervorgerufene Besserungseffekt bei AS scheint somit nicht durch einen Anstieg des Kortisolspiegels mit daraus resultierender Immunsuppression verursacht zu sein. Möglicherwei-se spielen Veränderungen des Zytokinmilieus durch die Hyperthermie eine Rolle. Schlüsselwörter Hyperthermie´Kortisol´Lymphozyten´ankylosierende SpondylitisAbstract Purpose: Modulation of the immune system by elevating body temperature raises the question whether immunemediated rheumatic diseases might be influenced by hyperthermia as well. Many experimental as well as clinical studies, however, produced contradictionary results. Mild passive full bath hyperthermia is a wide spread physical therapy in the rehabilitative process in inactive ankylosing spondylitis. Until now, the reasons for the favourable influence on complaints are unknown. Method: We studied 24 persons (12 patients with AS and 12 healthy controls): all of them received a whole body (full bath) hyperthermia (until the body temperature reached 38.5 8C sublingual; duration 50 minutes). Blood was taken at the beginning and every 30 minutes (about 4 hours) after the whole body hyperthermia for the measurement of cortisol, total lymphocytes, B-, T-, CD4-and CD8 cells. Results: During the study time we found no significant increase in the cortisol and no change in the total lymphocytes, and the subpopulations. Conclusion: The favourable influence on complaints in patients with AS after a mild passive whole-body (full bath) hyperthermia seems not to be the result of an immunosuppression. Further studies are needed to clarify whether serial application cause an immunemodulation, or if a longer observation time is required to verify a ¹stress reactionª. Probably the whole body hyperthermia provoke an alteration of the inflammatory/antiinflammatory cytokines and enhanced antioxidant effects as components of the therapeutic success.

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Thermotherapy of Pain, Trauma, and Inflammatory and Degenerative Rheumatic Diseases

Cited by 19 publications

References 48 publications

Magnetic Materials in Promoting Bone Regeneration

Magnetic Materials in Promoting Bone Regeneration

Hyperthermia in rheumatic diseases. A promising approach?

Einfluss der milden Hyperthermie auf die Blutspiegel von Kortisol und Lymphozytensubpopulationen bei Patienten mit ankylosierender Spondylitis und Gesunden

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