2016
DOI: 10.1590/1806-9061-2016-0299
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The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning

Abstract: KeywordsLead poisoning, humic acid substances, thyroid gland, chicken.Submitted: April/2016 Approved: August/2016 ABSTRACT Lead (Pb) is a heavy metal, which adversely affects thyroid gland function and structure. Due to its high molecular weight and abundant functional groups, humic acid substances (HAS) can form chelates with heavy metals. The experiment was conducted to evaluate the prophylactic effect of HAS on thyroid hormone levels and histopathological lesions of laying hens exposed to lead (Pb) pois… Show more

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Cited by 17 publications
(8 citation statements)
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“…in concurrence with existing study, Thyrotropin blood elevated in the levels of workers expos-ed to Pb -and source-of-lead. (11). (2) shows the means, standarddeviation, maximum and minimum of thyroxine (T4), Thyrotropin (TSH) triiodothyronine (T3), and Thyroglobulin-Ab (Tg-Ab) for the three studied groups.…”
Section: Resultsmentioning
confidence: 99%
“…in concurrence with existing study, Thyrotropin blood elevated in the levels of workers expos-ed to Pb -and source-of-lead. (11). (2) shows the means, standarddeviation, maximum and minimum of thyroxine (T4), Thyrotropin (TSH) triiodothyronine (T3), and Thyroglobulin-Ab (Tg-Ab) for the three studied groups.…”
Section: Resultsmentioning
confidence: 99%
“…Laurberg et al (2003) stated that HS might be goitrogenic because it releases substances during intestinal degradation which inhibit one or more enzymes and transporters involved in thyroid hormone production. Sahin et al (2016) illustrated that feeding 0.15% HS may bind heavy metals and play a role in the recovery of thyroid gland structure and function. In the present study, addition of HS alone did not improve the thyroid activity, whereas the administration of HS in combination with B .…”
Section: Discussionmentioning
confidence: 99%
“…KNHANES data also include the data on serum levels of fT4, which are also widely used as a measure of thyroid function, but we did not determine the effect of fT4 on the association between blood lead and MetS. However, TSH is independently affected by lead exposure regardless of other thyroid hormones [9,29,41], whereas the effect on other thyroid hormones is associated with the duration of exposure to lead [9]. Since KNHANES does not provide relevant data on the duration of exposure to environmental risk factors, it would be inappropriate to use fT4 as an indicator of thyroid function.…”
Section: Plos Onementioning
confidence: 99%