The effect of halothane dose on striatal dopamine: an in vivo microdialysis study

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

“…No data in the literature support this hypothesis. In contrast, a number of studies have consistently shown that halothane increases striatal DA levels (Ford and Marsden 1986;Savaki et al 1986;Spampinato et al 1986;Osborne et al 1990;Stahle et al 1990;Miyano et al 1993;Mantz et al 1994;Shiraishi et al 1997;Keita et al 1999) whereas ketamine has no effect (Ylitalo et al 1976;Koshikawa et al 1988;Lannes et al 1991;Micheletti et al 1992;Onoe et al 1994;Mantz et al 1994;Irifune et al 1997;Tsukada et al 2000).…”

“…This effect is thought to be due to a facilitation of DA neurotransmission although several studies indicate that ketamine has no significant effect on striatal DA levels (Ylitalo et al 1976;Koshikawa et al 1988;Lannes et al 1991;Micheletti et al 1992;Onoe et al 1994;Mantz et al 1994;Irifune et al 1997;Tsukada et al 2000). Volatile anesthetics such as halothane have been consistently shown to release striatal DA (Ford and Marsden 1986;Savaki et al 1986;Spampinato et al 1986;Osborne et al 1990;Stahle et al 1990;Miyano et al 1993;Mantz et al 1994;Shiraishi et al 1997;Keita et al 1999). In addition, several authors showed that anesthesia by itself might have a significant influence on radioligand binding in vivo and that this effect might introduce severe bias in the interpretation of results obtained from in vivo competition studies.…”

Halothane anesthesia decreases the extracellular level of dopamine in rat striatum: a microdialysis study in vivo

“…1, the induction of halothane anesthesia significantly decreased the level of dopamine in the dialysates (Fr. [2][3][4] and increased the levels of DOPAC (Fr. 2-13), 3-MT (Fr.…”

“…[3][4][5][6][7][8][9][10], and HVA (Fr. [3][4][5][6][7][8][9][10][11][12][13], as compared with the control group. During a 4-h recovery period from anesthesia, the level of dopamine increased rapidly, but the levels of dopamine metabolites recovered with a delay.…”

“…Halothane has been reported to increase [2][3][4] or not to affect [5] the interstitial level of brain dopamine during anesthesia. In our previous microdialysis studies in vivo in freely moving and anesthetized rats [6], sevoflurane, a newly developed general anesthetic, and isoflurane significantly decreased the dialysate concentration of dopamine and significantly increased that of dopamine metabolites.…”