Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Ginovart, Nathalie; Hassoun, Wadad; Cavorsin, Marion Le; Veyre, Laurent; Bars, Didier Le; Leviel, Vincent

doi:10.1016/s0893-133x(02)00285-3

Cited by 23 publications

(19 citation statements)

References 66 publications

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“…A separate study of the effect of anesthesia in pigs (Alstrup et al 2010) using isoflurane and propofol demonstrated the relative insensitivity of yohimbine to the effects of anesthesia compared to the binding of another tracer, SCH23390. However, anesthesia may potentiate the effect of amphetamine, as it has been shown that inhalation anesthetics including isoflurane increase monoamine release (Ginovart et al 2002;McCormick et al 2011), potentially leading to an overestimation of the effect of the stimulant in our study compared to the awake condition.…”

Section: Discussionmentioning

confidence: 76%

“…Anesthetics play an important role in the interpretation of binding data and even more in that of pharmacological challenges (Ginovart et al 2002;Hassoun et al 2003;McCormick et al 2011;Tsukada et al 1999). A separate study of the effect of anesthesia in pigs (Alstrup et al 2010) using isoflurane and propofol demonstrated the relative insensitivity of yohimbine to the effects of anesthesia compared to the binding of another tracer, SCH23390.…”

Section: Discussionmentioning

confidence: 99%

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Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

2012

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

2012

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“…The primary limitations of this study were the ones inherent to PET scanning with 11 C-raclopride. Although this radiotracer is commonly used for the evaluation of DA release (Volkow et al, 1994;Carson et al, 1997;Schlaepfer et al, 1997;Ginovart et al, 2002;Brody et al, 2004Brody et al, , 2006Marenco et al, 2004;Barrett et al, 2004;Scott et al, 2007) and generally demonstrates DA release when expected, the short half-life and variable pharmacokinetics of the radiotracer make its use logistically challenging for human studies, and can produce considerable variability within groups, as observed here (Figure 1). …”

Section: Discussionmentioning

confidence: 84%

Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette

Brody

Mandelkern

Olmstead

et al. 2008

Neuropsychopharmacol

166

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Prior studies have demonstrated that both nicotine administration and cigarette smoking lead to dopamine (DA) release in the ventral striatum/nucleus accumbens. In tobacco-dependent individuals, smoking denicotinized cigarettes leads to reduced craving, but less pleasure, than smoking regular cigarettes. Using denicotinized cigarettes and 11 C-raclopride positron emission tomography (PET) scanning, we sought to determine if nicotine is necessary for smoking-induced DA release. Sixty-two tobacco-dependent smokers underwent 11 C-raclopride PET scanning, during which they smoked either a regular or denicotinized cigarette (double-blind). Change in 11 C-raclopride binding potential (BP) in the ventral striatum from before to after smoking was determined as an indirect measure of DA release. Cigarette craving, anxiety, and mood were monitored during scanning. Smoking a regular cigarette resulted in a significantly greater mean reduction in ventral striatal 11 C-raclopride BP than smoking a denicotinized cigarette. Although both groups had reductions in craving and anxiety with smoking, the regular cigarette group had a greater improvement in mood. For the total group, change in BP correlated inversely with change in mood, indicating that greater smoking-induced DA release was associated with more smoking-related mood improvement. Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release.

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“…The BP of [ 11 C]raclopride (BP raclo ), a radioligand antagonist of dopamine (DA) receptors of the D 2 type, exemplifies this technical problem. In animals, a moderate reduction in BP raclo was observed after amphetamine administration (2 mg kg -1 ) under ketamine anaesthesia [12,13] but amphetamine administration had no effect on BP raclo under halothane anaesthesia [14]. However, amphetamine is known to produce a dramatic release of DA in these conditions [15,16].…”

Section: Introductionmentioning

confidence: 99%

PET study of the [ 11 C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow

Hassoun

Cavorsin

Ginovart

et al. 2003

European Journal of Nuclear Medicine and Molecular Imaging

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Cats were trained to stay in a containment box, without developing any signs of behavioural stress, while their head was maintained in a position that allowed positron emission tomography (PET) experiments to be performed. The binding potential for [(11)C]raclopride (BP(raclo)), a radioligand with good specificity for dopamine (DA) receptors of the D(2) type, was measured in the striatum and in three experimental situations: awake, anaesthetised with ketamine (50 mg kg(-1) h(-1); i.m.) and anaesthetised with halothane (1.5%). Non-specific binding was evaluated in the cerebellum. In the striatum of both sides, the BP(raclo) was unmodified by ketamine anaesthesia when compared with awake animals. In contrast, a large increase in BP(raclo) was observed under halothane anaesthesia. The non-specific binding of [(11)C]raclopride, evaluated in the cerebellum, was also unchanged under ketamine anaesthesia but greatly increased under halothane anaesthesia. To evaluate whether changes in the cerebral blood flow (CBF) resulting from the different experimental situations could be at the root of these discrepancies, injections of [(15)O]H(2)O were performed; measurements revealed a drastically increased CBF under halothane anaesthesia and a slight enhancement under ketamine anaesthesia, when compared with the waking state. These results are the first to be obtained on this topic in awake cats, and show that the BP(raclo) is greatly dependent on alterations in the CBF.

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Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Cited by 23 publications

References 66 publications

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette

PET study of the [ 11 C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow

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