Halothane anesthesia decreases the extracellular level of dopamine in rat striatum: a microdialysis study in vivo

Adachi, Yushi; Uchihashi, Yoshitaka; Watanabe, Kazuhiko; Satoh, Tetsuo

doi:10.1007/s005400050072

Cited by 19 publications

(11 citation statements)

References 35 publications

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“…No difference has been shown in [ 11 C]raclopride binding between awake and isoflurane anesthetized monkeys (Tsukada et al, 2002), but several studies have shown that isoflurane effects the DA system. In rats, isoflurane and halothane (at similar doses to what was used in here) have been found to decrease extracellular DA and increase DA metabolites (Adachi et al, 2000; Adachi et al, 2005). In our studies, this would result in an attenuation of the effect of alcohol on BP ND .…”

Section: Discussionsupporting

confidence: 53%

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET

Sullivan

Risacher

Normandin

et al. 2011

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Microdialysis studies report that systemic alcohol increases extracellular dopamine in the rat striatum. The present study examined whether changes in striatal dopamine could be detected in rats using small animal positron emission tomography (PET). PET images were acquired in 44 alcohol-naïve male Wistar and alcohol-preferring (P) rats. Subjects received up to three [11C]raclopride scans (rest, alcohol, and saline). Animals were anesthetized with isoflurane and secured on a stereotactic-like holder during all scans. Blood samples were collected from the tail or lateral saphenous vein of 12 animals 10 minutes after tracer injection for determination of blood alcohol concentration (BAC). Time activity curves were extracted from the striatum and the cerebellum and binding potential (BPND) was calculated as a measure of D2 receptor availability. Wistars given 1.0g/kg alcohol (20%v/v) I.V. or 3.0g/kg alcohol (20%v/v) I.P showed significant alcohol-induced decreases in BPND. In P rats (given 1.5, 2.25, or 3.0 g/kg alcohol), no individual group showed a statistical effect of alcohol on BPND, but taken together, all P rats receiving I.P. alcohol had significantly lower BPND than rest or saline scans. Large decreases in BPND were primarily observed in rats with BAC above 200 mg%. Also, a significant difference was found between baseline BPND of Wistars who had undergone jugular catheterization surgery for I.V. alcohol administration and those who had not. These preliminary results suggest that alcohol-induced DA release in the rat striatum is detectable using small animal PET given sufficiently large cohorts and adequate blood alcohol levels.

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Section: Discussionsupporting

confidence: 53%

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET

Sullivan

Risacher

Normandin

et al. 2011

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“…Compounds that alter regulation of dopamine function can alter endogenous dopamine concentration, which in turn presents a mechanism by which FAL kinetics could be altered (Endres and Carson, 1998;Morris et al, 1995;Yoder et al, 2004). Many anesthetics have been documented to have effects on basal dopamine levels, potentially via effects on dopamine release (Mantz et al, 1994;Salord et al, 1997) or reuptake (Adachi et al, 2000;Byas-Smith et al, 2004;Eckenhoff and Fagan, 1994;el-Maghrabi and Eckenhoff, 1993;Sabeti et al, 2003;Tsukada et al, 1999;Votaw et al, 2003). The PET literature is equivocal (even within laboratories) with respect to the effects of ketamine and isofluorane on the binding of [ 11 C]-labeled D 2 antagonists (Kobayashi et al, 1995;Onoe et al, 1994;Tsukada et al, 1999Tsukada et al, , 2000.…”

Section: Discussionmentioning

confidence: 96%

Assessment of IP injection of [18F]fallypride for behavioral neuroimaging in rats

Yoder

Mock

Zheng

et al. 2011

Journal of Neuroscience Methods

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“…Those data, however, were collected under anesthesia, within a few hours of probe implantation. Such potential confounds (Westerink et al, 1988) (Adachi et al, 2000;Hamilton et al, 1992;Westerink and De Vries, 1988) are avoided in most modern studies. There is a single report that reverse dialysis of L-TYR 100 μM elevated extracellular DA levels in striatum of awake animals by ~ 30% (Fusa et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

L-Tyrosine availability affects basal and stimulated catecholamine indices in prefrontal cortex and striatum of the rat

et al. 2017

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We previously found that L-tyrosine (L-TYR) but not D-TYR administered by reverse dialysis elevated catecholamine synthesis in vivo in medial prefrontal cortex (MPFC) and striatum of the rat (Brodnik et al., 2012). We now report L-TYR effects on extracellular levels of catecholamines and their metabolites. In MPFC, reverse dialysis of L-TYR elevated in vivo levels of dihydroxyphenylacetic acid (DOPAC) (L-TYR 250 – 1000 μM), homovanillic acid (HVA) (L-TYR 1000 μM) and 3-methoxy-4-hydroxyphenylglycol (MHPG) (L-TYR 500 – 1000 μM). In striatum L-TYR 250 μM elevated DOPAC. We also examined L-TYR effects on extracellular dopamine (DA) and norepinephrine (NE) levels during two 30 min pulses (P2 and P1) of K+ (37.5 mM) separated by t = 2.0 h. L-TYR significantly elevated the ratio P2/P1 for DA (L-TYR 125 μM) and NE (L-TYR 125 – 250 μM) in MPFC but lowered P2/P1 for DA (L-TYR 250 μM) in striatum. Finally, we measured DA levels in brain slices using ex-vivo voltammetry. Perfusion with L-TYR (12.5 – 50 μM) dose-dependently elevated stimulated DA levels in striatum. In all the above studies, D-TYR had no effect. We conclude that acute increases within the physiological range of L-TYR levels can increase catecholamine metabolism and efflux in MPFC and striatum. Chronically, such repeated increases in L-TYR availability could induce adaptive changes in catecholamine transmission while amplifying the metabolic cost of catecholamine synthesis and degradation. This has implications for neuropsychiatric conditions in which neurotoxicity and / or disordered L-TYR transport have been implicated.

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Halothane anesthesia decreases the extracellular level of dopamine in rat striatum: a microdialysis study in vivo

Cited by 19 publications

References 35 publications

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET

Assessment of IP injection of [18F]fallypride for behavioral neuroimaging in rats

L-Tyrosine availability affects basal and stimulated catecholamine indices in prefrontal cortex and striatum of the rat

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Halothane anesthesia decreases the extracellular level of dopamine in rat striatum: a microdialysis study in vivo

Cited by 19 publications

References 35 publications

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET

Assessment of IP injection of [18F]fallypride for behavioral neuroimaging in rats

L-Tyrosine availability affects basal and stimulated catecholamine indices in prefrontal cortex and striatum of the rat

Contact Info

Product

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Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET

Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [¹¹C]raclopride PET