“…Compounds that alter regulation of dopamine function can alter endogenous dopamine concentration, which in turn presents a mechanism by which FAL kinetics could be altered (Endres and Carson, 1998;Morris et al, 1995;Yoder et al, 2004). Many anesthetics have been documented to have effects on basal dopamine levels, potentially via effects on dopamine release (Mantz et al, 1994;Salord et al, 1997) or reuptake (Adachi et al, 2000;Byas-Smith et al, 2004;Eckenhoff and Fagan, 1994;el-Maghrabi and Eckenhoff, 1993;Sabeti et al, 2003;Tsukada et al, 1999;Votaw et al, 2003). The PET literature is equivocal (even within laboratories) with respect to the effects of ketamine and isofluorane on the binding of [ 11 C]-labeled D 2 antagonists (Kobayashi et al, 1995;Onoe et al, 1994;Tsukada et al, 1999Tsukada et al, , 2000.…”