The effect of gradually increased blood flow on ischemia-reperfusion injury in rat kidney

Durrani, Noreen; Yavuzer, Reha; Mittal, Vijay K.; Bradford, Melinda; Lobocki, Catherine; Silberberg, Boris

doi:10.1016/j.amjsurg.2005.10.032

Cited by 26 publications

(12 citation statements)

References 12 publications

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“…VintenJohansen et al [29] reported that gradual restoration of coronary blood flow during the initial 30 minutes of reperfusion to achieve a "gentle reperfusion" reduced infarct size and postischemic myocardial blood flow defects in a model of ischemia reperfusion. Durrani et al [24] demonstrated that gradually increasing blood flow in reperfusion phase decreases ischemic injury in ipsilateral and contralateral rat kidneys.…”

Section: Discussionmentioning

confidence: 98%

“…Truly, it is demonstrated that blood flow of some tissues such as testis [22,23], cremaster [4], kidney [24], bowel [25], limb [12], and myocard [11] are higher in the initial reperfusion phase than the level of preischemic period, that is, overflow. If oxygen-derived free radicals indeed are a major cause of reperfusion injury in the ischemic tissue, it may be possible to reduce injury by decreasing the accessibility of molecular oxygen at the time of reperfusion [13].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury

Akçora

Altuğ

Balcı

et al. 2008

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury

Akçora

Altuğ

Balcı

et al. 2008

Journal of Pediatric Surgery

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“…It has been reported that blood flow is higher in testis [13,14], cremaster muscle [15], kidneys [16], bowel [17], limbs [18], and myocardium [19] in the initial reperfusion phase and that there is even higher blood flow, called overflow [20], in these organs compared with the preischemic period. If oxygen-derived free radicals are a major cause of tissue injury after reperfusion, it should be possible to prevent the sudden burst of free radicals and thereby control the damage in the ischemic area.…”

Section: Discussionmentioning

confidence: 99%

The long-term protective effects of short-interval postconditioning in testicular ischemia-reperfusion injury in rats

Özkisacik¹,

Erdem²,

Durmaz³

et al. 2012

Journal of Pediatric Surgery

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“…In addition, the effects of gradual reperfusion and hindered lymphatic transport on tissue status will need to be addressed (12,30). Nonetheless, even in the absence of these factors, the multi-factorial base of pressure ulcer development in deep tissues from compression and ischemic factors has been confirmed.…”

Section: Discussionmentioning

confidence: 99%

Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle

Gawlitta

Oomens

Bader

et al. 2007

Journal of Applied Physiology

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Gawlitta D, Oomens CW, Bader DL, Baaijens FP, Bouten CV. Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle. J Appl Physiol 103: 464-473, 2007. First published April 19, 2007 doi:10.1152/japplphysiol.01374.2006.-Prolonged periods of tissue compression may lead to the development of pressure ulcers, some of which may originate in, for example, skeletal muscle tissue and progress underneath intact skin, representing deep tissue injury. Their etiology is multifactorial and the interaction between individual causal factors and their relative importance remain unknown. The present study addressed the relative contributions of deformation and ischemic factors to altered metabolism and viability. Engineered muscle tissue was prepared as previously detailed (14) and subjected to a combination of factors including 0% oxygen, lactic acid concentrations resulting in pH from 5.3 to 7.4, 34% compression, and low glucose levels. Deformation had an immediate effect on tissue viability {[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay}, which increased with time. By contrast, hypoxia evoked metabolic responses (glucose and lactate levels) within 24 h, but viability was only reduced after 48 h. In addition, lactic acidification downregulated tissue metabolism up to an acid concentration (ϳ23 mM) where metabolism was arrested and cell death enhanced. A similar tissue response was observed during glucose deprivation, which, at negligible concentration, resulted in both a cessation of metabolic activity and a reduction in cell viability. The combination of results suggests that in a short-term (Ͻ24 h) deformation, extreme acidification and glucose deprivation increased the level of cell death. By contrast, nonextreme acidification and hypoxia influenced tissue metabolism, but not the development of cell death. These data provide more insight into how compression-induced factors can lead to the onset of deep tissue injury.

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The effect of gradually increased blood flow on ischemia-reperfusion injury in rat kidney

Cited by 26 publications

References 12 publications

Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury

Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury

The long-term protective effects of short-interval postconditioning in testicular ischemia-reperfusion injury in rats

Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle

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