Aim: Testicular torsion is a serious urological emergency, usually involving newborns, children, and adolescents which can lead to subfertility and infertility. Prevention of testicular damage caused by torsion is still a clinical and experimental problem. So far many chemicals and drugs have been investigated for decreasing ischemia/reperfusion (I/R) injury in experimental animals. The possible protective effect of darbepoetin alfa, a novel erythropoietic protein, on testicular tissue after I/R injury was examined in this study. Methods: Thirty rats were divided into three groups: sham operation, torsion/detorsion, and torsion/detorsion plus darbepoetin alfa groups. After torsion (2 hours) and detorsion (4 hours), bilateral orchiectomy was performed. Malondialdehyde, nitric oxide and glutathione levels were determined in testicular tissue. Results: Administration of darbepoetin alfa caused a decrease of malondialdehyde and nitric oxide levels and an increase in glutathione levels compared with the torsion/detorsion group. In addition, histological injury scores were significantly decreased in the treatment group more than the torsion/detorsion group.
Conclusion:The results suggest that darbepoetin alfa may be a potential protective agent for preventing testicular injury caused by testis torsion.
The current study aimed to detect parasites in Hatay Mountain Gazelles (Gazella gazella), which are categorized as endangered according to the International Union for Conservation of Nature. The present study was conducted in Hatay Mountain Gazelle Wildlife Development Area, where 40 gazelles inhabited (30 ♀, 10 ♂), 15 of which were over three years old as well-considered adults. Fecal samples were taken from 60 fecal foci immediately after the defecation of the gazelles. Each of the fecal samples was analysed with Benedek sedimentation, Fülleborn flotation and Bearman-Wetzel methods and examined under a light microscope. In addition, Ixodid ticks were collected from an injured gazelle which was brought to Hatay Mustafa Kemal University, Wildlife Rescue and Rehabilitation Center, then were identified under the stereomicroscope. Nematodirus spp. (5/60, 8%), Marshallagia spp. (4/60, 7%), Trichostrongylus spp. (3/60, 5%) eggs, Dictiyocaulus filaria larvae (3/60, 5%) and Eimeria spp. oocysts (9/60, 15%) were determined based on the microscopic examination. Ixodid tick samples were identified as Rhipicephalus turanicus (2 ♀, 3 ♂). Thus this is the first report of the existence of parasites in Hatay Mountain Gazelles in Turkey. It is thought that skin and fecal examinations should be performed to prevent parasitic diseases in gazelles.
The result of the current study showed that histological healing and union of SS tenorrhaphy differ from that in primary tendon injury and healing. Further studies are required to clarify the healing stages at the tenorrhaphy site.
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