The Effect of Ginger and Thyme on Some Biochemical Parameters in Diabetic Rats

Hanna, Emily T; Aniess, Walaa; Khalil, A. M.; Abdalla, E. B.; Hassanin, Elsayed Abdul Khalik; Nagib, Ereny Wilson

doi:10.9790/3008-09335461

Cited by 5 publications

(8 citation statements)

References 39 publications

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“…The reduction of TC and TG were also reported by 15 [ 21 , 26 , 29 , 30 , 34 , 35 , 38 , 41 , 44 , 49 , 52 , 54 , 56 , 59 , 60 ] and 14 [ 21 , 26 , 29 , 30 , 34 , 35 , 38 , 41 , 44 , 49 , 52 , 56 , 59 , 60 ] studies respectively. Ginger has been shown to improve low-density lipoprotein-cholesterol (LDL-C) [ 26 , 29 , 30 , 35 , 38 , 52 , 54 , 56 , 59 ] and high-density lipoprotein-cholesterol (HDL-C) [ 26 , 29 , 30 , 35 , 38 , 49 , 56 , 59 , 60 ] levels in nine studies. One study reported contradictory results for TC, TG, and LDL-C, as well as two studies for HDL-C [ 23 , 44 ].…”

Section: Resultssupporting

confidence: 52%

“…Twenty-eight of 31 studies showed that ginger intake lowers blood glucose levels [ 24 , 25 , 27 , 29 , 30 , 34 – 43 , 47 – 49 , 51 – 53 , 55 – 61 ]. On the contrary, in 2 studies, blood glucose levels increased [ 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies evaluated the potential effect of ginger on kidney function indicators. In 17 of 21 studies ginger supplementation reduced serum creatinine levels [ 21 , 23 , 26 – 30 , 35 , 38 , 44 , 47 – 49 , 52 , 53 , 57 , 59 ]. Creatinine levels, on the other hand, increased in one study [ 22 ] and remained unchanged in three others [ 24 , 37 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Creatinine levels, on the other hand, increased in one study [ 22 ] and remained unchanged in three others [ 24 , 37 , 60 ]. Ginger decreased serum levels of urea, blood urea nitrogen (BUN), and uric acid in 13 [ 24 , 29 , 30 , 35 , 38 , 44 , 47 – 49 , 51 , 52 , 54 , 60 ], 6 [ 21 , 26 , 27 , 29 , 37 , 59 ], and 6 [ 35 , 48 , 49 , 51 , 57 , 59 ] studies, respectively. On the contrary, urea and uric acid levels were increased in one study [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

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Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

Veisi

Zarezade

Rostamkhani

et al. 2022

BMC Complement Med Ther

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Objective Diabetic kidney disease affects approximately 40% of diabetic patients and is the leading cause of chronic kidney disease (CKD) worldwide. As a result, preventing renal complications in diabetic patients is critical. Ginger (Zingiber Officinale Rosco) is a popular spice and natral medicine. The present study was a systematic review focused on the existing evidence of the renoprotective effect of ginger extract on some features of diabetic kidney disease. Methods The literature was searched in online databases such as PubMed, Scopus, EMBASE, ProQuest databases, and Google Scholar from inception to July 2022. Results This review included 41 articles that met the eligibility criteria. Ginger supplementation was found to be associated with a significant decrease in blood glucose in 28 studies. Nine studies showed a significant reduction in malondialdehyde (MDA) after supplementation. Also, seventeen studies showed decreased serum levels of creatinine. Fifteen studies reported a decrease in total cholesterol (TC) and fourteen studies showed a lowered triglycerides (TG) concentrations. In twenty-six studies, ginger reduced renal injuries due to diabetes. Conclusion Ginger may improve blood sugar indices, lipid profile, some inflammatory markers, oxidative stress, and pathologic injuries in diabetic kidney disease. However, future well-designed clinical trials and meta-analyses are required for a solid consensus.

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Section: Resultssupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

Veisi

Zarezade

Rostamkhani

et al. 2022

BMC Complement Med Ther

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show abstract

“…Promising results in terms of antidiabetic activity of thyme have been observed in both streptozotocin [ 13 ] and alloxan models [ 48 ] of diabetes mellitus in rats, suggesting its potential use in the treatment of metabolic syndrome. The intake of thyme extract managed to reduce serum concentrations of cholesterol and triglycerides, but we did not observe these effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats

Rašković¹,

Pavlović²,

Kvrgić³

et al. 2015

BMC Complement Altern Med

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BackgroundHerbal supplements are widely used in the treatment of various liver disases, but some of them may also induce liver injuries. Regarding the infuence of thyme and its constituents on the liver, conflicting results have been reported in the literature. The objective of this study was to examine the influence of two commonly used pharmaceutical formulations containing thyme (Thymus vulgaris L.), tincture and syrup, on carbon tetrachloride-induced acute liver injury in rats.MethodsChemical composition of investigated formulations of thyme was determined by gas chromatography and mass spectrometry. Activities of enzyme markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured using the kinetic spectrophotometric methods. Liver morphology was characterized by light microscopy using routine hematoxylin and eosin staining.ResultsThymol was found to be predominant active constituent in both tincture and syrup. Investigated thyme preparations exerted antioxidant effects in liver by preventing carbon tetrachloride-induced increase of lipid peroxidation. Furthermore, co-treatment with thyme preparations reversed the activities of oxidative stress-related enzymes xanthine oxidase, catalase, peroxidase, glutathione peroxidase and glutathione reductase, towards normal values in the liver. Hepatotoxicity induced by carbon tetrachloride was reflected by a marked elevation of AST and ALT activities, and histopathologic alterations. Co-administration of thyme tincture resulted in unexpected exacerbation of AST and ALT values in serum, while thyme syrup managed to reduce activites of aminotransferases, in comparison to carbon tetrachloride-treated animals.ConclusionsDespite demonstrated antioxidant activity, mediated through both direct free radical scavenging and activation of antioxidant defense mechanisms, thyme preparations could not ameliorate liver injury in rats. Molecular mechanisms of diverse effects of thyme preparations on chemical-induced hepatotoxicity should be more in-depth investigated.

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Effects of black seed and thyme leaves dietary supplements against malathion insecticide-induced toxicity in experimental rat model

Khalifa

Alkhalaf

2020

Journal of King Saud University - Science

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The Effect of Ginger and Thyme on Some Biochemical Parameters in Diabetic Rats

Abstract: Diabetes mellitus (DM) is

Cited by 5 publications

References 39 publications

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats

Effects of black seed and thyme leaves dietary supplements against malathion insecticide-induced toxicity in experimental rat model

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