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out is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. This study aimed to discover the beneficial effects of feeding cinnamon or / and ginger, as a powder form, on the consequence symptoms of gout on induced hyperuricemic rats. Forty nine male albino rats weighing 192 ±23g were divided into 7 equal groups; negative control group fed on standard diet only, while the other 6 experimental groups were injected orally with ethanol (1.8g per kilogram of body weight) every 24 hour for eight days to induce hyperuricemia, after confirmation they fed on standard diet only (positive control) or with adding 1% & 2% ginger, 1% & 2% cinnamon and mixture of 1% ginger + 1% cinnamon of total diet weight for continued four weeks after adaptation period. Serum uric acid, urea and creatinine, serum liver enzymes (AST, ALT, and ALP) activities, total protein, serum albumin and globulin levels were determined. Results revealed that supplementations with ginger, cinnamon or their mixture for hyperuricemic rats diets; declined the feed efficiency ratios, while increased relative weight of liver and kidneys significantly (p<0.05) ameliorated proportionally with the level of adding, also increments of uric acid, urea and creatinine levels were decreased significantly, furthermore decreased the raised serum levels of ALT, AST & ALP enzymes' activities and ameliorated significantly the documented decrements in the levels of serum total proteins and albumin comparing with positive control group. Histopathological kidneys' investigation revealed that higher supplementations with 2% ginger, cinnamon or their mixture groups modulate all undesirable changes recorded in kidneys of positive control group. These outcomes could mention that using ginger and cinnamon may improve kidney functions, liver enzymes and protein fractions, especially the mixture of them which was the most beneficial effects recorded; it could be used as hypouricemic agent and adjuvant treatment for gout disease.
he Red Quinoa seeds (RQ seeds) shows a higher number of total phenolic and flavonoids content. Therefore, the protective effect of the RQ seeds versus oxidative stress induced by Alloxan and carbon tetrachloride (CCl4) may treatment in rats. Fifty-six healthy male albino rats were randomly divided into three main groups. The first group of healthy rats (8 rats) was negative control and fed on commercial diet. The second group (24 rats) received CCl4 injections subcutaneously (for two weeks); while, the third group (24 rats) were fasted for 24 hours, injected with one dose prepared Alloxan by intraperitoneal injection to induce oxidative Stress. Then both main 2 groups were divided into 3 subgroups (8rats /each) and treated by different concentrations of RQ seeds as for 6 weeks. The rats were weighed weekly and at the end of the experimental, the animals were fasted overnight, anesthetized; sacrificed and weighted the organs excise" liver, kidney and Pancreas". Results showed that stress groups (Alloxan and CCl4) were significantly increased risk for oxidative stress. However, the results indicated that a diet fortified at 5g and 10g RQ seeds improves weight gain, increased antioxidant enzymes (SOD, CAT and GPx), reduces liver enzymes, kidney function, lipid profiles, serum glucose and reduces the risk of organ functions (liver, kidney and pancreas), related to oxidative stress, when compared to stress groups. More specifically, a diet with 10g RQ seeds reduced the adverse effect of oxidative stress.
Background and Aim: Our research investigates black, white and mixture of fresh berries role in liver injury caused by CCl 4 through biochemical parameters and histopathological determinations.Methods: Using berry as preventing or caring agents in comparing with treating or relieving or might curing agents against CCl 4 hepatotoxicity. Injection with CCl 4 was in the second 10 days, while preventing showed that feeding with berry on the first 10 days and relieving was feeding with berry on the third 10 days.Results: Preventing infected rats with white berry increased weight (17%), food efficiency ratio FER (6%), decreased aspartate aminotransferase (AST) (81%), urea (25.5%) comparing to infected rat group. Risk factor in lipid profile showed improvement by preventing black, white followed by mixture berries (26-58%) compared with CCl 4 group. Preventing with black, white then mixture berry showed significant improvement for risk factor. Generally, optimistic data has been found for preventing black berry in malondialdehyde (MDA) and fucosidase values in the final stage. In the first stage, preventing white and mixture fresh berry showed significant increase for antioxidant and fucosidase activity, respectively. Histopathological profiles indicated that relieving black berry and protected mixture were much enhanced than protected black and relieving mixture, respectively. Conclusion:Carbon tetrachloride is showing infection and hepatotoxicity in liver diseases due to its reactive intermediates. White, black and their equal mixture in the diet of Sprague-Dawley rats showed protective and even relieving for CCl 4 toxicity.
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