The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis

Patel, Shaheen; Mathan, Joyce; Vaghefi, Ehsan; Braakhuis, Andrea

doi:10.1007/s00417-015-3168-y

Cited by 43 publications

(34 citation statements)

References 23 publications

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“…Dietary antioxidants have a key role in oxidative stress reduction by inhibiting oxidative reactions and removing free radical intermediates [24]. Our findings of higher dietary intake of vitamin C and reduced outcomes of glaucoma, cataracts, and age-related macular degeneration are consistent with findings from previous studies [25,26,27,28,29]. β-carotene was also identified to reduce the risk of oxidative stress-related eye diseases with higher dietary intake.…”

Section: Discussionsupporting

confidence: 91%

“…Interestingly, trivial or unclear associations were found between the consumption of flavonoids and the incidence of ocular disease, in contrast to emerging data on the effect of flavonoid consumption on visual acuity in those with GLA [29]. The dietary consumption of flavonoids in the study population ranged from 0.15 to 2 g daily, which is similar to the values reported in the general population [3].…”

Section: Discussionsupporting

confidence: 43%

“…The range is quite varied and studies demonstrating a benefit to ocular function generally supplement with flavonoids, rather than rely on dietary intake. The bioavailability of flavonoids is quite low, potentially affecting outcomes [29]. …”

Section: Discussionmentioning

confidence: 99%

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The Association between Dietary Intake of Antioxidants and Ocular Disease

2017

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Abstract:To assess the association between dietary antioxidant intake and the incidence of the three major oxidative stress-related eye diseases, cataracts, glaucoma, and age-related macular degeneration, 78 cases from the University of Auckland Optometry and Vision Science clinic and 149 controls were recruited. Participants completed an antioxidant food-frequency questionnaire, analysed through multiple logistic regression. Protective associations were identified with higher consumption of fruit and vegetables (OR = 0.99; 95% CI: 0.98, 1.00; p = 0.004), vitamin C (OR = 0.63; 95% CI: 0.23, 1.03; p = 0.022), and β-carotene (OR = 0.56; 95% CI: 0.15, 0.98; p = 0.007). Meanwhile, harmful associations were observed with greater consumption of meat/nuts (OR = 1.03; 95% CI: 1.01, 1.05; p = 0.006) and cholesterol (OR = 1.09; 95% CI: 1.50, 2.46; p = 0.005). Diets rich in fruit and vegetables appear to be protective against cataracts, glaucoma, and age-related macular degeneration, while diets higher in meat and nuts may increase the risk of oxidative stress-related eye diseases. In addition, higher intakes of vitamin C and β-carotene from food, with reduction of dietary cholesterol intake, may be beneficial towards the outcome of oxidative stress-related eye diseases.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 43%

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The Association between Dietary Intake of Antioxidants and Ocular Disease

2017

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“…In the current issue of Graefe's Archive for Clinical and Experimental Ophthalmology, Patel et al evaluate the efficacy of flavonoids in glaucoma and ocular hypertension, performing a review and a meta-analysis of the currently published data, including only randomized controlled trials [8]. The number of included studies was surprisingly small: among the initially 16,840 screened articles, only six trials encompassing a total of 214 participants could be included, based on the inclusion criteria.…”

mentioning

confidence: 99%

“…A neuroprotective and microvascular effect of flavonoids may have played a role in this process, both at the ocular and cerebral level. In order to evaluate the effect of flavonoids on ocular blood flow, the same study [8] included a review of three reports (using different measurement methods, and therefore not submitted to meta-analysis). The review suggested a significant improvement of ocular blood flow (measured by laser Doppler flowmetry or by laser speckle flowgraphy) after flavonoid treatment.…”

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confidence: 99%

Flavonoids and glaucoma: revisiting therapies from the past

Miléa

Aung

2015

Graefes Arch Clin Exp Ophthalmol

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Quercetin and its role in modulating endoplasmic reticulum stress: A review

Eisvand

Tajbakhsh

Seidel

et al. 2021

Phytotherapy Research

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The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the function of the ER, resulting in ER stress.Under stress conditions, the cells initiate a defensive procedure known as the unfolded protein response (UPR). Cases of severe stress lead to autophagy and/or the induction of cell apoptosis. Many studies implicate ER stress as a major factor contributing to many diseases. Therefore, the modulation of ER stress pathways has become an attractive therapeutic target. Quercetin is a plant-derived metabolite belonging to the flavonoids class which presents a range of beneficial effects including anti-inflammatory, cardioprotective, anti-oxidant, anti-obesity, anti-carcinogenic, anti-atherosclerotic, anti-diabetic, anti-hypercholesterolemic, and anti-apoptotic activities. Quercetin also has anti-cancer activity, and can be used as an adjuvant to decrease resistance to cancer chemotherapy. Furthermore, the effect of quercetin can be increased with the help of nanotechnology. This review discusses the role of quercetin in the modulation of ER stress (and related diseases) and provides novel evidence for the beneficial use of quercetin in therapy.

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The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis

Abstract: Meta-analyses showed that flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension (OHT), and appear to play a part in both improving and slowing the progression of visual field loss.

Cited by 43 publications

References 23 publications

The Association between Dietary Intake of Antioxidants and Ocular Disease

The Association between Dietary Intake of Antioxidants and Ocular Disease

Flavonoids and glaucoma: revisiting therapies from the past

Quercetin and its role in modulating endoplasmic reticulum stress: A review

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