The Association between Dietary Intake of Antioxidants and Ocular Disease

Braakhuis, Andrea; Raman, Ryan; Vaghefi, Ehsan

doi:10.3390/diseases5010003

Cited by 36 publications

(25 citation statements)

References 31 publications

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“…The lowest ability to reduce the degree of ferric ion oxidation was found in the 'Hokkaido' (48.57 mM Fe(II)/100 g dm), 'Marina di Chiggia' (58. 19 mM Fe(II)/100 g dm), and 'Green Hubbard' cultivars (66.34 mM Fe(II)/100 g dm). When 80% methanol was used as the solvent, all the cultivars exhibited higher antioxidative activity.…”

Section: Ferric Reducing Antioxidant Power (Frap)mentioning

confidence: 99%

Optimization of Extraction Conditions for the Antioxidant Potential of Different Pumpkin Varieties (Cucurbita maxima)

2020

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Antioxidants are a wide group of chemical compounds characterized by high bioactivity. They affect human health by inhibiting the activity of reactive oxygen species. Thus, they limit their harmful effect and reduce the risk of many diseases, including cardiovascular diseases, cancers, and neurodegenerative diseases. Antioxidants are also widely used in the food industry. They prevent the occurrence of unfavourable changes in food products during storage. They inhibit fat oxidation and limit the loss of colour. For this reason, they are often added to meat products. Many diet components exhibit an antioxidative activity. A high antioxidative capacity is attributed to fruit, vegetables, spices, herbs, tea, and red wine. So far, the antioxidative properties of various plant materials have been tested. However, the antioxidative activity of some products has not been thoroughly investigated yet. To date, there have been only a few studies on the antioxidative activity of the pumpkin, including pumpkin seeds, flowers, and leaves, but not the pulp. The main focus of our experiment was to optimize the extraction so as to increase the antioxidative activity of the pumpkin pulp. Variable extraction conditions were used for this purpose, i.e., the type and concentration of the solvent, as well as the time and temperature of the process. In addition, the experiment involved a comparative analysis of the antioxidative potential of 14 pumpkin cultivars of the Cucurbita maxima species. The study showed considerable diversification of the antioxidative activity of different pumpkin cultivars.Sustainability 2020, 12, 1305 2 of 21 (neutralize) reactive oxygen species (ROS), including hydroperoxide radicals, superoxide anion radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals [1,2]. The following compounds are usually listed as strong antioxidants: Carotenoids (e.g.

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Section: Ferric Reducing Antioxidant Power (Frap)mentioning

confidence: 99%

Optimization of Extraction Conditions for the Antioxidant Potential of Different Pumpkin Varieties (Cucurbita maxima)

2020

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“…Some studies have outlined the potential nutritional or dietary influences on AMD risk [7,[16][17][18][19]. Data emerging from the Age-Related Eye Disease Study (AREDS), advocates a healthy diet with supplementation of zinc, lutein/zeaxanthin and vitamins C and E, as an effective strategy for reducing AMD progression from its early to visually-disabling late stage [16].…”

Section: Introductionmentioning

confidence: 99%

Dietary patterns were not associated with age-related macular degeneration: a cross-sectional analysis in the Irish Nun Eye Study

et al. 2018

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Background Analysing dietary patterns (DP) evaluates overall dietary intake, taking account of its complexity, quality, variance and the interaction between different foods, providing an alternative approach for the evaluation of nutritional influences on agerelated macular degeneration (AMD) risk. Aims To evaluate the relationship between DP and AMD in an older female population. Methods Data was analysed from the cross-sectional Irish Nun Eye Study involving 1233 older women with a restricted lifestyle (mean age 76.3 years [range, 56-100 years). The Wisconsin Age-related Maculopathy Grading System was used to classify digital colour macular fundus images and dietary intake was assessed using a food frequency questionnaire (n = 1033). A posteriori DP were derived using principal component analysis. Logistic regression models examined associations between DP and AMD risk with adjustment for confounders. Results Two DP were identified: a 'healthy' pattern characterised by a high intake of oily fish, wholegrains, vegetables and fruit; and an 'unhealthy' pattern characterised by high-fat dairy products, sugar, sweets and chips. Of the participants included within the analysis, AMD status were categorised as controls (n = 818, 86.9%), early AMD (n = 83, 8.8%) and late AMD (n = 21, 2.2%). Regression analysis failed to identify any significant associations between healthy or unhealthy DP and AMD risk, in unadjusted and adjusted models. Conclusion No evidence of an association between the DP identified and AMD risk was detected in this well-characterised population. Further research is required to determine the overall dietary influences on AMD risk in general population cohorts.

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“…A recent case-control study conducted by Braakhuis et al indicated that a higher intake of vitamin C was associated with a reduced risk of oxidative stress-related eye diseases (OR: 0.63; 95% CI, 0.23-1.03; p = 0.022) [46].…”

Section: Vitamins C and Ementioning

confidence: 99%

“…A recent case-control study indicated a protective association between dietary intake of -carotene and oxidative stress-related eye diseases (OR: 0.56; 95% CI, 0.15-0.98; p = 0.007) [46]. However, contradictory results originated from the Blue Mountains Study, which showed a significantly positive correlation between -carotene dietary intake and AMD (R: 1.36; 95% CI, 1.02-1.81 per 1-SD increase; p = 0.039), with a significant trend across increasing tertiles of dietary -carotene intake.…”

Section: -Carotenementioning

confidence: 99%

The Role of Diet, Micronutrients and the Gut Microbiota in Age-Related Macular Degeneration: New Perspectives from the Gut-Retina Axis

Rinninella

Mele

Merendino

et al. 2018

Preprint

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Age-related macular degeneration (AMD) is a complex multifactorial disease and the primary cause of legal and irreversible blindness among individuals aged >=65 years in developed countries. Globally, it affects 30-50 million individuals, with an estimated increase of approximately 200 million by 2020 and approximately 300 million by 2040. Currently, the neovascular form may be able to be treated with the use of anti-VEGF drugs, while no effective treatments are available for the dry form. Many observational studies, such as AREDS-1 and AREDS 2, have shown a potential role of micronutrient supplementation in lowering the risk of progression of the early stages of AMD. Recently, low-grade inflammation, sustained by dysbiosis and a leaky gut, has been shown to contribute to the development of AMD. Given the ascertained influence of the gut microbiota in systemic low-grade inflammation and its potential modulation by macro- and micro-nutrients, a potential role of diet in AMD has been proposed. This review discusses the role of the gut microbiota in the development of AMD. Using PubMed, Web of Science and Scopus, we searched for recent scientific evidence discussing the impact of dietary habits (high fat and high glucose or fructose diets), micronutrients (vitamins C, E, and D, zinc, beta-carotene, lutein and zeaxanthin) and omega-3 fatty acids on the modulation of the gut microbiota and their relationship with AMD risk and progression.

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The Association between Dietary Intake of Antioxidants and Ocular Disease

Cited by 36 publications

References 31 publications

Optimization of Extraction Conditions for the Antioxidant Potential of Different Pumpkin Varieties (Cucurbita maxima)

Optimization of Extraction Conditions for the Antioxidant Potential of Different Pumpkin Varieties (Cucurbita maxima)

Dietary patterns were not associated with age-related macular degeneration: a cross-sectional analysis in the Irish Nun Eye Study

The Role of Diet, Micronutrients and the Gut Microbiota in Age-Related Macular Degeneration: New Perspectives from the Gut-Retina Axis

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