The Effect of Electroconvulsive Therapy on CSF Amine Metabolites in Schizophrenic Patients

Cooper, S.J.; Leahey, William J.; Green, D F; King, David J.

doi:10.1192/bjp.152.1.59

Cited by 13 publications

(7 citation statements)

References 27 publications

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“…In 1988, Cooper described the effect of ECT on cerebrospinal fluid amine levels in schizophrenia and reported that no significant changes were observed in the concentration of MHPG. 31 These results suggest that catecholamine levels increase immediately after ECT, but do not increase for the long term. The present finding that ECT does not alter urine catecholamine levels after ECT over the long term might make a contribution to understanding of physiological change among many factors for cardiovascular adverse events in ECT therapy.…”

Section: Discussionmentioning

confidence: 83%

Urine catecholamine levels are not influenced by electroconvulsive therapy in depression or schizophrenia over the long term

Ito

Hatta

Usui

et al. 2012

Psychiatry Clin Neurosci

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Aim: Change in catecholamine seems to be associated with not only effects of electroconvulsive therapy (ECT), but also adverse events associated with ECT. Our aim in this study was to investigate whether or not ECT influences the concentration of catecholamine over the long term. Patients with a major depressive episode or schizophrenia, diagnosed according to DSM-IV criteria, who were newly admitted to Juntendo University Hospital to receive ECT, were recruited.Methods: Urine was collected during the 24 h before the first ECT treatment, during the 24 h after the first ECT treatment, during the 24 h after the final ECT treatment and during the 24 h 1 week after the final ECT treatment. Heart rate, the Hamilton Rating Scale for Depression and the Positive and Negative Syndrome Scale were assessed before and after ECT.Results: Twenty-four patients were included in the final sample, which consisted of 14 patients with major depressive episodes and 10 patients with schizophrenia. Abnormal electrocardiograms were indicated in four patients with depression during the ECT operation but all recovered naturally. There were no significant differences in the levels of dopamine, adrenaline or noradrenaline the day before the first ECT, a day after the first ECT, a day after the final ECT and a week after the final ECT. Conclusion:These results suggest that ECT does not alter urine catecholamine levels after ECT over the long term. Further studies will be required to confirm these findings in a larger sample of patients.

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Section: Discussionmentioning

confidence: 83%

Urine catecholamine levels are not influenced by electroconvulsive therapy in depression or schizophrenia over the long term

Ito

Hatta

Usui

et al. 2012

Psychiatry Clin Neurosci

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“…5,[14][15][16][17][18] A further 17 studies included at least one patient older than 60 years of age within a mixed-age cohort, or a mixed-diagnoses cohort where outcomes specific to patients with primary psychotic conditions were reported (Table 2). 4,10,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]…”

Section: Resultsmentioning

confidence: 99%

Acute electroconvulsive therapy in the elderly with schizophrenia and schizoaffective disorder: a literature review

Kumagaya

Halliday

2019

Australas Psychiatry

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Objectives: This study reviewed the evidence regarding the efficacy of acute electroconvulsive therapy for primary psychotic conditions in the elderly. Methods: A literature search was performed using the Medline, Embase and Cochrane databases. Results: Acute electroconvulsive therapy resulted in an improvement of psychotic symptoms in almost all elderly patients, a large proportion of whom had treatment-resistant conditions. No electroconvulsive therapy related fatalities or severe medical complications were encountered. Conclusions: Acute electroconvulsive therapy may present a valuable treatment modality for elderly patients with primary psychotic conditions who do not respond adequately to antipsychotic medications.

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“…Increases in the concentrations of the dopamine main metabolite homovanillic acid (HVA) but not of the serotonin or noradrenaline metabolites, 5-hydroxyindoleacetic acid (5-HIAA) and methoxyhydroxyphenylglycol (MHPG), respectively, have been found in CSF samples taken one day after the first ECT, compared to samples taken one day before ECT [5]. The increases were not present in samples taken one day after the final ECT of the course.…”

Section: Manolis Markianos · John Hatzimanolis · Lefteris Lykourasmentioning

confidence: 91%

Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients

Markianos

Hatzimanolis

Lykouras

2002

European Archives of Psychiatry and Clinical Neurosciences

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The prolactin (PRL) increases in plasma, induced by the electrical stimulus during electroconvulsive therapy (ECT), is a consistent finding that can be studied in order to obtain information about its actions on the brain neurotransmitter systems, the most probable candidates being the serotonergic and the dopaminergic system. Central serotonergic and dopaminergic responsivity may also be assessed using neuroendocrine challenge tests. In this study, we measured the PRL responses during the first ECT of a therapeutic course in 15 male depressive patients, of mean age 49.2 +/- 14.5 (range 22 to 68 years), and score in the HDRS of 29 +/- 8 (range 18 to 43 points). Before the ECT course, we assessed the central serotonergic and dopaminergic responsivities, by measuring the PRL responses to the administration of the serotonin uptake inhibitor clomipramine (CMI) intravenously, and, two days later, the PRL responses dopamine receptor blocker haloperidol (HAL), administered intramuscularly. The CMI and HAL tests were also performed in 15 healthy male subjects. The PRL responses to CMI of the patients were blunted compared to healthy controls, while the PRL responses to HAL were not significantly different from controls. Searching for correlations among the maximal PRL responses to the three stimuli in the patient's group, we found that the PRL responses to ECT were significantly correlated to the PRL responses to i. m. HAL (r = 0.8205, N = 15, p < 0.001) and not to the PRL responses to i. v. CMI (r = 0.1713, n. s.). It is suggested that the rises in PRL during ECT reflect the responsivity of the hypothalamus-pituitary dopaminergic system, and seem to be the result of a transient decrease in the inhibitory dopaminergic input of the hypothalamus to the pituitary lactotrophs, caused by the electrical stimulus and the subsequent seizure.

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The Effect of Electroconvulsive Therapy on CSF Amine Metabolites in Schizophrenic Patients

Cited by 13 publications

References 27 publications

Urine catecholamine levels are not influenced by electroconvulsive therapy in depression or schizophrenia over the long term

Urine catecholamine levels are not influenced by electroconvulsive therapy in depression or schizophrenia over the long term

Acute electroconvulsive therapy in the elderly with schizophrenia and schizoaffective disorder: a literature review

Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients

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