The effect of drugs and diet on orthodontic tooth movement

Krishnan, Vinod; Zahrowski, James J.; Davidovitch, Zéev

doi:10.1002/9781118916148.ch13

Cited by 7 publications

(7 citation statements)

References 114 publications

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“…Osteoclast apoptosis can inhibit bone resorption and decrease the rate of alveolar bone remodeling during orthodontic tooth movement. Bisphosphonate has been recommended as a potential pharmacological agent for orthodontic anchorage reinforcement [6]. Our findings confirm that zoledronate bisphosphonate in the gel form possesses good stability at 25°C and therefore has potential in topical drug application for the oral cavity.…”

Section: Discussionsupporting

confidence: 76%

“…The decreasing value was in accordance with the bisphosphonate drug half-life, which is up to 10 years. The rising temperature can also accelerate the chemical degradation of a substance [6].…”

Section: Discussionmentioning

confidence: 99%

“…However, anchorage loss and other side-effects continue to occur, thereby compromising the treatment outcomes [3][4][5]. Besides the mechanical appliances, studies have shown that undesirable tooth movement could be prevented by blocking the bone resorption with a pharmacological agent [6].…”

Section: Introductionmentioning

confidence: 99%

“…Bisphosphonates are widely used as drugs to treat osteoporosis and other bone diseases. Past studies have shown that the administration of bisphosphonate can increase the amount of osteoclast apoptosis and thereby inhibit tooth movement [6,7]. There are two types…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of physical stability and drug content of zoledronate bisphosphonate gel

Monika

Sahlan²,

Krisnawati

et al. 2018

jos

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Introduction: The gel emulsion form of zoledronate bisphosphonate has been proven to increase the number of osteoclasts via apoptosis when applied topically. The gel form is commonly used for topical application in the oral cavity. Objectives: We aimed to evaluate the physical stability of zoledronate bisphosphonate in its gel form to assess its suitability for clinical application. Material and methods: The gel formulation was prepared using carboxymethylcellulose, glycerine, and sodium benzoate in a dosage form of 40 μg of zoledronate per 25 mg of the gel. The prepared gels were stored at 25°C and 40°C for 28 days and evaluated for viscosity, pH value, spreadability, adhesive strength, and drug content on days 1, 7, 14, and 28 of incubation. Results: Throughout the study, at 40°C of storage, the gel demonstrated significantly increasing viscosity and adhesive strength, but decreasing spreadability. However, the pH and drug content decreased at 25°C and 40°C. Conclusion: Zoledronate bisphosphonate gel showed stability in physical characteristics and drug content when stored at 25°C for 28 days.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of physical stability and drug content of zoledronate bisphosphonate gel

Monika

Sahlan²,

Krisnawati

et al. 2018

jos

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“…In general, reports studying bone metabolism following NSAIDs administration have been incongruous; differences in animals and study design (dosage, route and period of administration, etc) have been implicated. 55,56 …”

Section: Discussionmentioning

confidence: 99%

Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

Kaklamanos

Makrygiannakis

Athanasiou

2020

Orthod Craniofacial Res

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Immediately after the removal of orthodontic appliances, the teeth might start to drift away from their corrected position in an attempt to reach a new equilibrium. Medications and biologic factors could potentially modulate these processes. The objective of the present systematic review is to systematically investigate and appraise the quality of the evidence regarding the effect of various medications and biologic factors on the rate of relapse following active tooth movement. Search without restrictions in eight databases and hand searching until April 2020 were conducted. Studies performed on animal models investigating the effects of medication and biologic factors on the rate of relapse following orthodontic tooth movement were considered. Following study retrieval and selection, relevant data were extracted and the risk of bias was assessed. Seventeen studies were finally identified, mostly at either high or unclear risk of bias. Ketorolac did not show any significant effects on relapse, while the administration of tetracycline, atorvastatin, psoralen and raloxifene decreased it. Overall, the same result was observed with bisphosphonates with the exception of low dosage of risedronate, which did not have an effect. Osteoprotegerin and strontium resulted in reduced relapse, but not in the immediate post‐administration period. Inconsistent or conflicting effects were noted after the use of simvastatin and relaxin. The quality of the available evidence was considered at best as low. It can be concluded that specific medications and biologic factors may have an effect on the rate of relapse following tooth movement. The orthodontist should be knowledgeable about the substances potentially affecting retention.

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Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review

Makrygiannakis

Kaklamanos

Athanasiou

2018

European Journal of Orthodontics

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The effect of drugs and diet on orthodontic tooth movement

Cited by 7 publications

References 114 publications

Evaluation of physical stability and drug content of zoledronate bisphosphonate gel

Evaluation of physical stability and drug content of zoledronate bisphosphonate gel

Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review

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