The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure

Abstract

These results suggest that sodium restriction leads to activation of antinatriuretic antidiuretic systems in HF patients. However, renal ability to synthesize dopamine is increased in this condition, probably as a counter-regulatory mechanism.

A dieta com baixo teor de sódio é de fato indicada para todos os pacientes com insuficiência cardíaca estável?

“…Our findings concerning the increase in plasma norepinephrine and serum aldosterone are in accordance with other studies [13][14][15] . Mechanisms to explain the neurohormonal…”

Hemodynamic and neuroendocrine responses to changes in sodium intake in compensated heart failure

“…The diagnosis of HF was confirmed by a twofold higher plasma NE concentration in patients compared with controls. Sodium intake was a major determinant of the sympathetic nervous activity as indicated by plasma NE levels, which confirms previous findings in untreated (4) and treated HF (1).…”

Manejo não-farmacológico de pacientes hospitalizados com insuficiência cardíaca em hospital universitário

“…20 Conversely, in a recent study euvolemic HF patients under diuretics and low-salt diet (100 mmol Na + / day) responded with volume depletion, renin-angiotensinaldosterone system activation, and decreased B-type natriuretic peptide levels. 21 The strategy of increasing diuretic dosages to compensate a free-sodium diet may worsen the neuro-humoral and fluid/electrolyte imbalance commonly associated with these patients. Failure to adhere to salt and fluid restrictions is one of the causes of the so-called diuretic resistance.…”