The Effect of Cyclopropane on Cardiac Work Capacity

Moe, Gordon K.; Rennick, Barbara R.; Freyburger, Walter A.; Malton, S. Donald

doi:10.1097/00000542-194911000-00006

Cited by 9 publications

(3 citation statements)

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“…Measurements of cardiac output, cardiac work and cardiac competence during cyclopropane anesthesia have not been made in man. In the dog the output of the heart is increased (23), the competence of the heart decreased (24), and the right atrial pressure elevated (25) by cyclopropane.…”

Section: Discussionmentioning

confidence: 99%

Circulatory Effects of Raised Airway Pressure During Cyclopropane Anesthesia in Man 1

Price¹,

King²,

Elder³

et al. 1951

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Circulatory Effects of Raised Airway Pressure During Cyclopropane Anesthesia in Man 1

Price¹,

King²,

Elder³

et al. 1951

J. Clin. Invest.

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“…So far, however, no case of ventricular fibrillation seems to have arisen spontaneously or as a result of the administration of adrenaline in a patient anaesthetised with halothane though nms of extra systoles have appeared. Possibly the hypotensive effect of the drug affords some protection against such incidents, in which a sudden rise in blood pressure may well be the precipitatinig factor (Moe et al, 1948).…”

Section: Irritability Of the Myocardiummentioning

confidence: 99%

Halothane

Hunter

1960

Int J Clinical Practice

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“…(Submitted for publication July 11, 1961;accepted October 27, 1961) In 1949 Moe, Rennick, Freyburger and Malton expressed surprise at the prevalent clinical use of cyclopropane, because its administration appeared to reduce cardiac contractility conspicuously in both intact dogs and canine heart-lung preparations (1). The effects of cyclopropane in heart-lung preparations have been repeatedly confirmed (2-4), but uncertainty attaches to measurements of cardiac contractility made during cyclopropane anesthesia in intact animals because they indicate every possible result from stimulation to pronounced depression (5)(6)(7).…”

mentioning

confidence: 99%

Ventricular Function and Autonomic Nervous Activity During Cyclopropane Anesthesia in Man*

Price¹,

Jones²,

Deutsch³

et al. 1962

J. Clin. Invest.

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In 1949 Moe, Rennick, Freyburger and Malton expressed surprise at the prevalent clinical use of cyclopropane, because its administration appeared to reduce cardiac contractility conspicuously in both intact dogs and canine heart-lung preparations (1). The effects of cyclopropane in heart-lung preparations have been repeatedly confirmed (2-4), but uncertainty attaches to measurements of cardiac contractility made during cyclopropane anesthesia in intact animals because they indicate every possible result from stimulation to pronounced depression (5-7).Since the question of cardiac competence during cyclopropane anesthesia achieves practical importance only when it relates to man, we believe it essential that it be answered in man. What follows is the result of an attempt to do so. METHODThe subj ects were 20 normal adult volunteers (5 resident physicians, 11 hospital orderlies, and 4 hospital patients prior to minor elective operations) 6 of whom were studied on two or more occasions. Each had fasted since the previous evening. All were studied in the morning in the supine position on a standard operating table.The following measurements were made in all instances: arterial pressure, by means of a Statham P23D strain gauge connected by polyethylene tubing to a 21-gauge thin-walled needle inserted in a brachial artery; right ventricular pressure, with a P23AA gauge connected to 0.9 mm ID polyethylene tubing which was introduced into an antecubital vein through a 13-gauge thin-walled needle; electrocardiogram (lead ii), with needle electrodes; and cardiac output by dye dilution (8), by means of 3-to 5-mg doses of T-1824 dye injected from a calibrated syringe through the ventricular catheter. The duration of injection ranged from 2 to 3 seconds. The optical density of arterial blood was measured by drawing it at a constant rate through a photometer. The relationship between density and dye concen-* Supported in part by Grants H-1568 C5-7, H-4589, and 2G-215-C2 from the United States Public Health Service.tration was established by measuring the density change produced by adding known amounts of dye to blood which had been withdrawn during the output determinations. Linearity of the photometer was satisfactory over the range 0 to 15 mg of T-1824 per L blood. Approximately 25 ml of blood was withdrawn for each output determination; the blood withdrawn was replaced by an equal volume of physiological saline solution. For the ventricular pressure measurements the transducer lay in the plane 5 cm dorsal to the angle of Louis. The risetime for the transducer-catheter system was 0.05 second.In the anesthetized subjects respired gases were withdrawn through a 20-gauge needle inserted into the airway and analyzed for Pco., by the method of Collier, Affeldt and Farr (9). In addition, end-expired gas samples were obtained from the same source by intermittent sampling with a 10 ml glass syringe and analyzed for cyclopropane (10). The Pco2 determinations were corrected for the presence of the anesthetic gas (11). In four conscio...

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The Effect of Cyclopropane on Cardiac Work Capacity

Cited by 9 publications

References 0 publications

Circulatory Effects of Raised Airway Pressure During Cyclopropane Anesthesia in Man 1

Circulatory Effects of Raised Airway Pressure During Cyclopropane Anesthesia in Man 1

Halothane

Ventricular Function and Autonomic Nervous Activity During Cyclopropane Anesthesia in Man*

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