Twelve male volunteers inspired concentrations of carbon dioxide in oxygen ranging from 7% to 14% for periods of 10– 20 minutes. Respiratory minute volume, arterial pressure, heart rate, and plasma concentrations of epinephrine, norepinephrine and 17-OH corticosteroids were increased in every subject during hypercarbia. Abnormal cardiac rhythm was infrequently observed. Following substitution of oxygen for the carbon dioxide-oxygen mixture, the altered measurements returned to normal over a period of roughly 10 minutes. Neither marked hypotension nor cardiac arrhythmia was observed after correction of hypercarbia. Submitted on January 8, 1960
1. Eleven normal subjects were studied before and after removal of 15 to 20% of their blood volume within 35 minutes.
2. This amount of blood loss did not produce conspicuous effects upon any of the usually measured circulatory or metabolic parameters.
3. The results suggest that the splanchnic circulation functions as an important blood reservoir in man, that it can be preferentially depleted of blood by a mechanism which does not automatically increase vascular resistance, and that the ability of our subjects to tolerate blood loss was attributable in large part to this response.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.