The effect of cycloplegia on biometric measurements using swept‐source optical coherence tomography‐based biometry

Abstract

Background: To evaluate the effect of pupil dilation obtained with cyclopentolate on biometric measurements using swept-source optical coherence tomography biometry. Methods: This study involved 63 eyes of 63 healthy volunteers. After ophthalmic examination, biometry measurements of the participants were obtained with IOL Master 700 (Carl Zeiss Meditec AG, Jena, Germany). After pre-dilation measurements were taken, subjects were given one drop of cyclopentolate hydrochloride ophthalmic solution three times at 10-minute intervals. When cycloplegia had been achieved, a dilated fundus examination was conducted and post-dilation measurements were taken with IOL Master 700. The biometric parameters were recorded and SPSS Software 22.0 was used for statistical analysis. Results: There was a significant increase in anterior chamber depth, anterior aqueous depth and central corneal thickness values after pupil dilation (p < 0.05). A significant decrease was observed in lens thickness values after cycloplegia (p < 0.05). There were no statistically significant differences between pre-dilation and post-dilation axial length, keratometry (K1, K2) and white-to-white values (p > 0.05). Conclusion: This study demonstrated there is no significant difference in axial length and keratometry measurements using swept-source optical coherence tomography biometry before and after cycloplegia.

Comparison of effects of mydriatic drops (1% cyclopentolate and 0.5% tropicamide) on anterior segment parameters

“…[ 14 ] showed that cycloplegia affects ACD and WTW distance but does not affect AL and keratometric values. In a study by Ozcalıskan et al ,[ 15 ] there was no significant change in AL, K1, K2, and WTW distance values after pupil dilatation; however, ACD, aqueous depth, and increase in CCT were significantly changed. Higashiyama et al .…”

“…In a previous study, there was no significant change in WTW distance values after pupil dilation with cyclopentolate. [ 15 ] Differently, Arriola-Villalobos et al . [ 17 ] demonstrated a significant change in WTW distance values before and after pupil dilatation with tropicamide.…”

Comparisons of atropine versus cyclopentolate cycloplegia in myopic children

“…Axial length elongation after cyclopentolate cycloplegia (9 ± 16 μm) could be explained by the decrease in choroidal thickness (−3 ± 11 μm at the subfoveal region) and the increase in the central cornea (6 ± 6 μm). Central corneal thickening may be due to the destruction of the corneal epithelium by agents and resultant corneal oedema, 6 or be a result of incremental changes in the tear film, since other studies have reported no significant changes using Pentacam, 9,10 which does not account for the tear film when measuring central corneal thickness. However, the underlying mechanisms for incremental changes in the tear film remain unclear.…”

“…Some of these changes are widely accepted (for example, reduced lens thickness, 5,6 deeper anterior chamber depth, [5][6][7][8][9][10] and no significant differences in axial length [6][7][8] and corneal power 6 ), whereas others remain equivocal, including choroidal thickness 11,12 and central corneal thickness. 5,6,9,10 However, all these studies were conducted on healthy children or adults only. Thus, the effect of cyclopentolate cycloplegia on myopic children -who are subjected to a higher frequency of use of cycloplegia in clinical practice to monitor myopia progression -has not been determined.…”

Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

“…The uses of cycloplegic agents include, but are not limited to, fundus examination, anterior segment assessment, refraction, and diagnosis and treatment of amblyopia using pharmacological penalization. 1,2 Evaluation of anterior segment structures has become crucial for the planning of cataract and refractive surgery, diagnosing and treating glaucoma and assessing corneal health. [3][4][5] Full assessment of the anterior segment is important for diagnosing and monitoring patients with glaucoma, performing corneal refractive surgery, intraocular lens (IOL) calculation, and the lens position in cataract surgery.…”